Institut National des Sciences Appliquées Rouen Normandie

Correlative microscopy reveals chemical short-range order and native oxide in medium-entropy alloys

High- and medium-entropy alloys can exhibit exceptional sets of mechanical and catalytic properties underpinned by the vast array of local atomic arrangements. Among the key features governing properties is the self-assembly of specific atomic neighborhoods, a process known as ch...

Hydroalkylation and hydroacylation of trifluoromethyl olefins by N-centered direct hydrogen atom transfer photocatalysis

The selective functionalization of trifluoromethyl olefins, while keeping the essential trifluoroalkyl moiety intact, remains a synthetic challenge. In this study, we report the use of an acridinium amidate as a direct hydrogen atom transfer (d-HAT) photocatalyst for the mild and...

Design of Potent, Non-Toxic Antimicrobial Agents Derived from the Frog Skin Peptide Raniseptin-PL Active Against Gram-Negative ESKAPE+ Pathogens

Background/Objectives: The frog skin peptide raniseptin-PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) is active against a range of antibiotic-resistant bacteria including ESKAPE+ pathogens, but its therapeutic potential is limited by high cytotoxicity against mammalian cells. The study ai...

General heat release rate surrogates for NH3/H2/N2 and H2 flames using Raman/Rayleigh/LIF accessible species

Accurate estimation of the heat-release rate (HRR) is essential for understanding and controlling ammonia–hydrogen combustion, yet conventional experimental surrogates are strongly dependent on operating conditions and typically rely on radicals measured by laser-induced fluoresc...

Exploring the spatial distribution of biomolecules in Pseudomonas aeruginosa biofilms formed on PDMS and lung explants by mass spectrometry imaging

Bacterial biofilms constitute a form of collective organization that enhances bacterial tolerance to both antibiotics and immune defences. Among bacteria, Pseudomonas aeruginosa (P. aeruginosa) is a major opportunistic pathogen, with marked biofilm-forming capacity, highly implic...

On the role of error metrics in the assessment of chemical kinetic mechanisms

Methods intended to decrease the computational cost of chemistry, such as mechanism reduction, neural-network surrogates, or genetic optimization, rely on metrics to assess agreement with reference datasets. However, the role of error definitions in the design of these metrics re...

Oxidative Fluorination of β-Ketoamides: Guanidinium Iodides as Iodoarene Alternatives

Abstract A guanidinium iodide-catalyzed oxidative fluorination of β-ketoamides enables umpolung α-fluorination, replacing iodoarenes with a simple iodide source. Using HF·pyridine as the fluoride source and mCPBA as the oxidant in dichloroethane, quaternary α-fluoro-β-ketoamides...

Aliphatic Diazirines Synthesis Mediated by Mild N -Chlorosuccinimide Oxidation

Abstract Diazirines have been known for decades as effective photoreactive moieties, with valuable applications in chemoproteomics. In recent years, they have received increasing interest in synthetic chemistry. Until recently, their access required a multistep process, which may...

Explainable Machine Learning Model for Early Hospital Admission Prediction in the Emergency Department: A Retrospective Analysis

Early prediction of hospital admission at emergency department triage may support clinical decision-making, patient flow coordination, bed planning and resource allocation. However, external validation of admission prediction models remains limited, while missing-data handling, c...

New mechanistic insights into the widely used LiPO2F2 additive enabled by ultra-high-resolution FTICR-MS

Understanding how electrolyte additives influence the formation and evolution of the solid electrolyte interphase (SEI) is essential for improving the durability of lithium‑ion batteries. In this work, we investigate the role of lithium difluorophosphate (LiPO2F2, LiDFP) in 1 M L...

Toward Climate-Responsive Ocean–Terrestrial Biorefineries: Integrating Algae and Agricultural Residues for Circular Bioeconomies

Abstract This paper evaluates climate-responsive biorefineries that integrate pelagic Sargassum with agricultural residues to advance circular bioeconomies. Building on scientific priorities emphasized at the 2025 One Ocean Science Congress and emerging policy directions from the...

Development of antibacterial wipes coated with nanofibers made from nisin and polyvinyl alcohol

Nosocomial infections caused by Staphylococcus aureus ( S. aureus ), a major pathogen that colonizes human skin, are a significant cause of morbidity and mortality. Effective management of S. aureus is essential, especially given the rising threat of antibiotic resistance. Innova...

MRU-YOLO: Marginal-Utility-Guided Selective Local Re-Observation for Small-Object Detection in UAV Imagery

Small-object details in high-resolution unmanned aerial vehicle (UAV) imagery are weakened when wide-area scenes are resized for detector input. Increasing input resolution or exhaustively processing local regions can recover spatial detail, but allocate computation without disti...