Institut de Recherche Vaccinale

Th1 and Th17 Responses to LTB and Colonization Factors Following Oral ETEC Vaccination

T helper cells (Th) are central to mucosal IgA induction and key targets for modulation by vaccine adjuvants. To improve understanding of cellular mechanisms underlying mucosal vaccine-induced immunity, we analyzed antigen-specific peripheral blood Th responses elicited by the or...

Persistence of immune responses 5 years after vaccination with a single dose of typhoid conjugate vaccine (TCV) in Nepalese children

Background A single-dose typhoid conjugate vaccine (TCV) has been recommended in endemic settings. Here we report the 5-year immunogenicity results post a single dose of TCV in Nepal. Methods We conducted a participant- and observer-blinded randomised trial (RCT) in Lalitpur, Nep...

Isolation and molecular characterization of serotype O foot-and-mouth disease virus circulating in cattle in East Java, Indonesia

Foot-and-mouth disease (FMD) is a highly contagious transboundary viral disease of cloven-hoofed animals that causes substantial economic losses worldwide. The re-emergence of FMD in Indonesia in 2022 after more than three decades of disease-free status has made continuous molecu...