Innovative Research (United States)

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport

The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL's key role in neuronal function. Many actions of CHL are stereospecific, as shown by differences from its 3 α -hydroxy epimer, epicholesterol (epiCHL). How this minor stru...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

Mathematical modeling of HBV–HDV transmission with superinfection: The role of vaccination and liver transplantation in disease dynamics

Hepatitis D virus (HDV) infection can substantially worsen the clinical outcomes of individuals infected with hepatitis B virus (HBV), making the prevention of HBV infection and the management of severe HBV–HDV cases important public-health priorities. This study introduces a nov...

Sensory nerves regulate bone homeostasis in response to mechanical unloading or reloading: evidence from a spaceflight experiment and ground-based mechanical unloading models

Mechanical loading is crucial for maintaining bone mass, and understanding how bone remodels in response to mechanical loading is essential for treating musculoskeletal disorders. Recently, sensory nerves inside bone were identified as mechanical regulators of bone homeostasis. H...

Multi-mode input–output model for cavity magnonics: Phase-resolved control of level repulsion, level attraction, and nonreciprocal transmission

We experimentally validate a unified input–output model that incorporates internal and external coupling phases across multiple cavity modes in a room-temperature cavity magnonic system. By explicitly accounting for both phase contributions, the model provides a clear interpretat...

FacilitatingJ-Aggregate Formation by LoweringActivation Energy to Achieve Ultrahigh Brightness for NIR-II FluorescenceImaging and Photoacoustic Imaging

Abstract Organic fluorophores operating in the second near-infrared window (NIR-II, 900–1700 nm) are plagued by low quantum yields (QYs) and diminished brightness in aqueous media. To address this challenge, we proposed a strategy of regulating the activation energy for aggregate...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

Cancer nanovaccine plus doxorubicin and immune checkpoint blockade overcomes chemoresistance and delays postsurgical recurrence

Chemotherapy for solid tumors has serious limitations due to acquired chemoresistance and frequent postsurgical recurrence. In this study, we developed a chemo-immunotherapy regimen combining a chemotherapeutic agent, a dendritic cell (DC)-activating cancer nanovaccine, and immun...