Innovative Research (United States)

FacilitatingJ-Aggregate Formation by LoweringActivation Energy to Achieve Ultrahigh Brightness for NIR-II FluorescenceImaging and Photoacoustic Imaging

Abstract Organic fluorophores operating in the second near-infrared window (NIR-II, 900–1700 nm) are plagued by low quantum yields (QYs) and diminished brightness in aqueous media. To address this challenge, we proposed a strategy of regulating the activation energy for aggregate...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

Cancer nanovaccine plus doxorubicin and immune checkpoint blockade overcomes chemoresistance and delays postsurgical recurrence

Chemotherapy for solid tumors has serious limitations due to acquired chemoresistance and frequent postsurgical recurrence. In this study, we developed a chemo-immunotherapy regimen combining a chemotherapeutic agent, a dendritic cell (DC)-activating cancer nanovaccine, and immun...