Indiana University

Ligand-Shell Softness Directs Symmetry Transitions in Nanotripod Superstructures

Abstract Low-symmetry, nonconvex nanocrystals offer access to superlattices with structural motifs that are difficult to realize from convex building blocks. Here, we show that polymer-grafted Gd2O3 nanotripods assemble into compact achiral and open chiral nanoporous superstructu...

“A Tilt Between Justice and Total Depravity”: The Criminalization of Black Women and the Expansion of Carceral Space in Detroit

Abstract This article examines the ways Black women and girls in Detroit, Michigan, were criminalized and punished as they encountered criminal courts, indeterminate sentences, women’s reformatories, and police brutality from the 1870s to the early 1900s. Detroit was uniquely sit...

Group postpartum care improves mental health among postpartum women: a randomized controlled trial in Ghana

Despite the significant contribution of poor perinatal mental health to maternal morbidity and mortality, mental health care is often overlooked and not prioritized during postpartum care in many developing countries. In a parallel randomized controlled trial in Ghana, we tested...

Stay Healthy for Your (Our) Community: Examining How Source Identity Affects Black Americans’ Responses to Targeted COVID-19 Messages

Many communications during the pandemic emphasized COVID-19’s disproportionate impact on Black Americans. Articles highlighting such racial health disparities can act as a form of health information targeting , which can be threatening when aimed at marginalized identities. In St...

Navigating prestige variants across multiple dimensions

Abstract In this study, we examine which characteristics are routinely associated with linguistic variants, and how the sociolinguistic and societal landscape may influence the range of possible characteristics by analyzing realizations of /r/ and /w/ in Haitian Creole. In Haitia...

Evaluation of volumetric DBS for lead analysis using ICP-MS/MS: addressing matrix effects and hematocrit variability

BACKGROUND: Lead testing in dried blood spots (DBS) offer a convenient alternative to venous blood draw; however, its adoption has been limited by variable extraction efficiency, matrix effects, and hematocrit-dependent recovery. To mitigate these challenges, we explored the util...

Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity

Abstract Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes....

Beyond Outcomes: Assessing the Process of Problem Solving Using Process Education

The link between a finished course assignment and the learning required to produce it is increasingly uncertain. In the era of generative artificial intelligence, polished coursework can be created in moments without demonstrating the reasoning, judgment, or productive struggle t...

Blue-sky thinking about pronunciation research and teaching

Abstract In the fall of 2024, Ron Thomson and Tracey Derwing invited 15 pronunciation scholars representing several subspecialties to participate in a full-day symposium to discuss directions for pronunciation research. To prepare for the symposium, held in conjunction with the P...

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

Abstract Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we describe a therapeutic approach to improve calcium homeostasis in a mouse mo...

Contemporary Update on Fracture-Related Infection: A Multidisciplinary Approach to Evaluation, Prevention, and Treatment

Fracture-related infection (FRI) can be a devastating complication after fracture surgery and presents many challenges for the treating clinician. A consensus definition including clinical, radiographic, and laboratory components has standardized the diagnosis and investigative e...

Bridging two kingdoms: binding interactions between enteric viruses and intestinal bacteria

ABSTRACT Enteric viruses are major causes of gastrointestinal disease worldwide and are primarily transmitted through the fecal-oral route. Upon entering the gastrointestinal tract, these viruses encounter the dense and diverse population of intestinal microbiota, leading to freq...

Reverse genetics and comparative pathogenesis of Lone Star virus

ABSTRACT Lone Star virus (LSV) is a bandavirus first isolated from Amblyomma americanum ticks in the United States and is phylogenetically related to severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Bhanja virus, each of which has been associ...

Development of items to assess noticeability and sun sensitivity among patients with non-segmental vitiligo

OBJECTIVES: Non-segmental vitiligo (NSV) is a chronic skin disease characterized by progressive, bilateral skin depigmentation that can impact health-related quality of life and psychosocial well-being. To assess emerging and new NSV treatments, patient-reported outcomes (PROs) t...

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer

Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) therapy, but only 25% of patients have durable responses. TG4010, a mucin 1 (MUC1) vaccine, has demonstrated activity in NSCLC. We conducted a multi-institutional study to determine the safety...

An Experience-Sampling Approach to Examining Cortisol and Testosterone Profiles in Bipolar and Depressive Mood Disorders

Emotion dysregulation is a core component of bipolar disorder (BD). However, there is a critical gap concerning the measurement of emotion-relevant neuroendocrine processes in this population. The present investigation examined neuroendocrine profiles (i.e., cortisol and testoste...

Chemosymbiotic trophic strategy in an Ediacaran tubular animal

Chemosymbiosis may have been a key driver of early animal evolution and diversification. Yet evidence for animal–microbe nutritional partnerships in the fossil record of early metazoans remains scarce, largely owing to the limited availability of robust geochemical proxies and su...

Appointment adherence, weight reduction, and retention at 9 months in Australian clinical obesity services: a retrospective cohort study

OBJECTIVE: This study aimed to compare demographic, clinical, and early engagement characteristics between participants retained and not retained at 9 months in specialist obesity services. METHODS: This retrospective cohort study analysed 235 records of patients (mean body mass...

Agentic or Experiencer? The Nonhuman Action in Ecofiction

The nonhuman has been widely studied in the humanities and social sciences (Cohen & Lemenager, 2016). While its meaning varies among disciplines and contexts, in literary studies the term nonhuman generally encompasses “plants, animals, spirits, gods, and, more recently, machines...