Indiana University School of Medicine

Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity

Abstract Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes....

Evaluation of volumetric DBS for lead analysis using ICP-MS/MS: addressing matrix effects and hematocrit variability

BACKGROUND: Lead testing in dried blood spots (DBS) offer a convenient alternative to venous blood draw; however, its adoption has been limited by variable extraction efficiency, matrix effects, and hematocrit-dependent recovery. To mitigate these challenges, we explored the util...

Prepregnancy Diet Quality Index and Adverse Pregnancy Outcomes

This cohort study of US births examines the association of preconception diet quality with adverse pregnancy outcomes.

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

Abstract Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we describe a therapeutic approach to improve calcium homeostasis in a mouse mo...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Moderators of the Effects of Telehealth Mindfulness-based Interventions for Chronic Pain

OBJECTIVES: Little is known about who benefits most from Mindfulness-Based Interventions (MBIs), and whether certain groups differentially benefit from different types of MBI formats (group-based versus non-group based). The present study uses data from a three-arm randomized con...

Candida Bloodstream Infection in Left Ventricular Assist Device Recipients: Case Series and Review of the Literature

Abstract Candida bloodstream infection (C-BSI) is a rare infection in patients with left ventricular assist devices (LVADs). We aim to describe the characteristics and outcomes of C-BSI. We performed a retrospective search for C-BSI in patients with LVADs at our institution from...

Reverse genetics and comparative pathogenesis of Lone Star virus

ABSTRACT Lone Star virus (LSV) is a bandavirus first isolated from Amblyomma americanum ticks in the United States and is phylogenetically related to severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Bhanja virus, each of which has been associ...

Bridging two kingdoms: binding interactions between enteric viruses and intestinal bacteria

ABSTRACT Enteric viruses are major causes of gastrointestinal disease worldwide and are primarily transmitted through the fecal-oral route. Upon entering the gastrointestinal tract, these viruses encounter the dense and diverse population of intestinal microbiota, leading to freq...

A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer

Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) therapy, but only 25% of patients have durable responses. TG4010, a mucin 1 (MUC1) vaccine, has demonstrated activity in NSCLC. We conducted a multi-institutional study to determine the safety...

Development of items to assess noticeability and sun sensitivity among patients with non-segmental vitiligo

OBJECTIVES: Non-segmental vitiligo (NSV) is a chronic skin disease characterized by progressive, bilateral skin depigmentation that can impact health-related quality of life and psychosocial well-being. To assess emerging and new NSV treatments, patient-reported outcomes (PROs) t...

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

Pediatrician Burnout Over Time: 2021–2025

OBJECTIVE Utilize a longitudinal study to examine over time whether (1) burnout has decreased since it peaked during the COVID-19 pandemic in 2021; (2) patterns are similar across pediatrician characteristics; and (3) changes in work and personal characteristics are linked to dec...

Comparison of Surgeon Expectations to Patient-Reported Outcomes Following Open Carpal Tunnel Release

Background: Open carpal tunnel release (OCTR) is an effective surgical treatment option for carpal tunnel syndrome (CTS). This study evaluates hand surgeon expectations of postoperative recovery versus patient-reported outcomes following OCTR through Patient-Reported Outcomes Mea...

HALO program marks another year of growth and collaboration

Patricia A. Olson is an associate editor for Headache: The Journal of Head and Face Pain. She has received honoraria from the American Academy of Neurology and the Headache Cooperative of the Northeast. Nan Cheng is an associate editor for Headache: The Journal of Head and Face P...

Counting fluorescent emitters with a single photon avalanche diode array

For decades, the photon counting histogram (PCH) was used as the sole method to quantify fluorophore numbers in a diffraction-limited focal volume. This technique combines spatial excitation profiles, and the distribution of photon counts to register the photon emission statistic...

Distinctive properties of the prion protein in the brain and retina in the amyloidosis associated with the PRNP F198S mutation

Abstract Prion protein (PrP) deposits in the form of diffuse and cored plaques occur in most gray matter areas of the brain of individuals affected by Gerstmann-Sträussler-Scheinker disease (GSS) associated with the F198S mutation in PRNP; however, the PrP deposits in the retina...

Closing the Value-Voice Disconnect: Operational Pointers for Healthcare Governance

The Value-Voice Disconnect is the gap between what hospital administration can count, meaning cost, throughput and measurable output, and what clinicians know from the bedside, which is contextual and largely uncounted. Naming the gap has not closed it. This paper turns the conce...

Closing the Value-Voice Disconnect: Operational Pointers for Healthcare Governance

The Value-Voice Disconnect is the gap between what hospital administration can count, meaning cost, throughput and measurable output, and what clinicians know from the bedside, which is contextual and largely uncounted. Naming the gap has not closed it. This paper turns the conce...

Closing the Value-Voice Disconnect: Operational Pointers for Healthcare Governance

The Value-Voice Disconnect is the gap between what hospital administration can count, meaning cost, throughput and measurable output, and what clinicians know from the bedside, which is contextual and largely uncounted. Naming the gap has not closed it. This paper turns the conce...