Indiana University School of Medicine

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment o...

Effect of Fitzpatrick Skin Type Prompting on Diagnostic Accuracy in Multimodal Large Language Models: A Within-Image Experimental Study

Multimodal large language models are increasingly used for dermatologic queries, but whether Fitzpatrick skin type (FST) labels affect diagnostic accuracy is unknown. We evaluated 656 biopsy-confirmed photographs from the Diverse Dermatology Images (DDI) dataset under no-FST, DDI...

Perceived helpfulness of 56 treatment options in patients with chronic pain: a retrospective review

BACKGROUND: Chronic pain affects approximately 20% of US adults and often requires multiple treatment modalities. Although many therapies are available, less is known about which treatments patients perceive as helpful in real-world settings. METHODS: This retrospective cohort st...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...

Pediatric Auditory-Perceptual Evaluation of Voice Part I: Voice Stimuli for Children

Purpose: The purpose of this study was to develop and test standardized stimuli for the Pediatric Auditory-Perceptual Evaluation of Voice protocol. The use of these stimuli for cepstral/spectral voice measures was also considered. Method: Three sets of standardized sentences and...

Bacterial Display of Genetically Encoded Macrocyclic Peptide Libraries Using Cysteine-Reactive Unnatural Amino Acids

Abstract Cyclic peptides are powerful scaffolds for modulating protein–protein interactions; however, methods for constructing cyclic peptide libraries for cell-surface display applications remain limited. Here, we present a bacterial surface display platform that enables site-sp...

Burden of Disease in Pediatric Tumor-Induced Osteomalacia: A Literature Review

Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). In children, TIO may be mistaken for more common causes of rickets and osteomalacia, including monogenic forms, leading to long diagnostic de...

Lifetime Concussions and Head Impact Exposure During Collegiate Athletics: A CARE Consortium Study

OBJECTIVE: Despite a growing interest in the long-term effects of concussion and repetitive head impacts (RHIs) on brain health, understanding is limited regarding the clinical and cognitive changes that may accrue during collegiate athletics. METHODS: Collegiate student-athletes...

Surgery Utilization Mediates Survival in Patients With Dementia and Stage I– III Colorectal Cancer

BACKGROUND: Dementia is associated with increased mortality among patients with colorectal cancer (CRC), and they receive less invasive evaluations, chemotherapy, and surgery. The objectives of this study were to (1) compare demographics and treatment patterns among individuals w...

How Does Receipt of Dementia Screening Impact Depressive Symptoms Among Patients and Their Family Members?

BACKGROUND: The impact of dementia screening on the mental health of older adults and their family members remains insufficiently understood, particularly in light of the bidirectional dynamics within the older adult-family dyad. This study aims to examine how dementia screening...

Halicin‑Rifampicin Combinations Are More Effective Than Monotherapy Against Biofilm‑Residing Staphylococcus Aureus and Prevent Emergence of Rifampicin Resistance

Background: Biofilms shield bacteria from immune defenses and antibiotics, contributing to implant-associated infections, particularly those caused by Staphylococcus aureus (S. aureus). Halicin, a repurposed antimicrobial with broad-spectrum activity, has shown promise against pl...