Indian Institute of Science Education and Research, Tirupati

Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

Abstract In many organisms, meiotic crossover recombination is suppressed near the extreme ends of chromosomes. Here we show that multiple, often chromosome-specific, suppressive mechanisms with differing ranges contribute to the consistently low enrichment of recombination-promo...

Sympatric pikas partition microhabitats differently across a spatial-elevational gradient

Abstract How closely related, ecologically similar species co-occur and navigate competition remains a central question in community ecology. Microhabitat partitioning in patchy environments can support the co-existence of sympatric species on small spatial scales. We quantified...

Concise Total Syntheses of (±)-Hirsuteine, (±)-Hirsutine, (±)-Corynantheine, and (±)-Dihydrocorynantheine

Abstract A concise and protecting-group-free synthesis of the four corynanthe alkaloids has been developed from a readily available indole precursor. The key step features a reagent-controlled cascade Hosomi–Sakurai/Pictet–Spengler cyclization that simultaneously constructs the C...

Trends and determinants of graft function in deceased donor kidney transplantation: influence of donor, recipient, and perioperative factors across eras

Background: Deceased donor kidney transplantation outcomes are influenced by donor, recipient, and perioperative variables. This study evaluates the impact of donor age, dialysis duration, and cold ischemia time (CIT) on graft survival. Methods: A retrospective analysis of demogr...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Liquid–liquid phase separation in a minimal explicit-solvent lattice model mimicking protein solutions

Biomolecular condensates play an essential role in cellular processes, and recent studies have focused on understanding their assembly and rational design principles. In this work, we have employed an explicit-solvent minimal statistical mechanical model based on the lattice-gas...