Huzhou Normal University

Design and Synthesisof Potential Quinoline-BasedSDH Inhibitors Inspired by Quinine Alkaloids with Activity againstPhytopathogenic Fungi and Bacteria

Abstract In pursuit of environmentally friendly agrochemicals, we employed the natural quinine alkaloid scaffold as a lead for the design and synthesis of three series of structurally diverse quinine derivatives and systematically evaluated their in vitro antibacterial and antifu...

Phase-specific relationships between cognitive function and life-space mobility in patients with ischemic stroke: implications for geriatric rehabilitation

Based on the Chronic Illness Trajectory Framework (CITF), this study aims to explore the longitudinal trajectories and dynamic reciprocal relationships between cognitive function and life-space mobility in older patients with ischemic stroke (IS) during a 1-year post-discharge fo...

Design, synthesis, crystal structure, fungicidal activity and in silico study of novel pyrazole carboxamide derivatives containing flexible chain

Pyrazole-containing compounds are significant in agrochemical discovery due to their diverse biological activities. Inspired by commercial succinate dehydrogenase inhibitor (SDHI) fungicides featuring flexible linkers, a series of novel pyrazole-carboxamide derivatives containing...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Balancing Microplastic Retention and Wetland Sustainability: A Salinity-Dependent LBM Transport Model

Constructed wetlands (CWs) are widely used as an ecological technology for wastewater treatment. However, the accumulation of microplastics (MPs) in their substrates may impair long-term performance and threaten the operational sustainability of these nature-based treatment syste...

Peer victimization and family dynamics in the association between childhood abuse and adolescent non-suicidal self-injury: a cross-sectional moderated mediation study

Childhood abuse is associated with adolescent non-suicidal self-injury (NSSI), but the roles of proximal peer experiences and family context remain unclear. A cross-sectional survey was conducted among 10,179 Chinese students (47.9% female; Mage = 14.16 years, SD = 1.86). A theor...

Pathways to medication adherence: a configurational analysis of psychiatric symptoms and medication attitude in patients with schizophrenia spectrum disorder receiving long-acting injectable antipsychotics

Medication non-adherence affects nearly half of patients with schizophrenia spectrum disorder and is associated with relapse and hospitalization. Long-acting injectable (LAI) antipsychotics may improve adherence, but their effectiveness likely depends on interactions between spec...

Adhesion Improvement in Diamond Films on Stainless Steel Under Scratch Conditions via Cr/CrSiVN Interlayers

Diamond films deposited on stainless steel using a Cr/CrSiN interlayer exhibit excellent adhesion under static conditions but poor adhesion under scratch conditions. We developed a new interlayer Cr/CrSiVN and investigated the influence of different vanadium (V) contents on the a...