Huntsman Cancer Institute

Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes—An umbrella review of systematic reviews and meta-analyses

Composite dietary and lifestyle indices capture the combined effects of multiple health-related behaviours and may better reflect real-world cancer risk and survivorship than single exposures. This umbrella review aimed to evaluate and grade the strength of evidence for associati...

The effectiveness of targeted visuals: Improving awareness of acral lentiginous melanoma among Hispanic and African American participants

Acral lentiginous melanoma (ALM) is an aggressive type of melanoma that disproportionally impacts people of color, with rising incidence among Hispanic/Latino populations and the highest mortality rate among African Americans. Given these disparities, innovative strategies for co...

GLP-1 Receptor Agonist Use Among Adults With Diabetes and Cancer History

This cross-sectional study examines how use of glucagon-like peptide-1 (GLP-1) receptor agonists varies among US adults with diabetes with or without a history of cancer.

Characteristics of ascitic fluid and diagnosis of bacterial peritonitis in malignant ascites: An observational study

Abstract Background Bacterial peritonitis in patients with malignant ascites (BP‐MA) is an understudied, high‐mortality condition. While ascitic polymorphonuclear (PMN) cell count ≥ 250 cells/mm 3 defines the diagnosis of spontaneous bacterial peritonitis (SBP) in patients with c...

Exposure to chemotherapy alters secondary drug sensitivity without genomic alterations in patient-derived ovarian cancer organoid models

Ovarian cancer has significant morbidity and mortality due to high rates of resistance to chemotherapy and recurrence. Our objective was to deploy patient-derived organoid (PDO) models of ovarian cancer to assess secondary drug sensitivity after exposure to chemotherapy in vitro....

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among p...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Ovarian high-grade serous carcinoma (HGSC) is an aggressive ovarian cancer with a heterogeneous tumor microenvironment (TME). Advances in single-cell RNA sequencing (scRNA-seq) and spatially-resolved transcriptomics have enabled the study of complex TME. This study explores conne...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...