Hunan University of Traditional Chinese Medicine

Perineural invasion in hepatocellular carcinoma: clinical evidence and mechanistic hypotheses

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. Emerging evidence in cancer neuroscience suggests that tumor–nerve crosstalk can modulate tumor growth, immune remodeling, dissemination, and therapy resistance. Perineural invasion (PNI) is a hallmark...

Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration

Intrauterine adhesion (IUA) is a fibrotic disorder resulting from aberrant repair following injury to the endometrial basal layer, leading to menstrual abnormalities, infertility, recurrent miscarriage, and pregnancy complications. Although hysteroscopic adhesiolysis remains the...

Shared Metabolic–Proteinopathy Axis in Alzheimer's Disease and Parkinson's Disease: Evidence for a Convergent but Not Identical Disease Spectrum

ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative disorders globally and have long been classified as clinically and pathologically distinct syndromes. AD is defined by amyloid‐β (Aβ) plaques and tau‐positive neurofibrilla...

Risk factors for sudden cardiac death in heart failure

Background: Heart failure (HF) is a global health burden with high mortality. Sudden cardiac death (SCD) remains a major complication, highlighting the need for accurate risk prediction. Methods: We conducted a systematic review and meta-analysis, guided by the Population, Interv...

Effectiveness of acupuncture combined with medication for mild cognitive impairment: a systematic review and meta-analysis protocol

Abstract Introduction Cognitive impairment is a global health crisis, which reduces quality of life and adds to the socio-economic burden. Previous meta-analyses have shown that the combination of acupuncture and conventional Western medicine may offer advantages over drug therap...

Identification of Kaempferol for Skeletal Muscle Wasting in Cancer Cachexia Through Bibliometric Analysis and Network Pharmacology: Metabolomic and Experimental Evaluation

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive skeletal muscle wasting, systemic inflammation, and metabolic dysregulation. Traditional Chinese medicine (TCM) contains numerous bioactive compounds with potential multitarget effects, but systematic...

Shenfu Injection attenuates isoproterenol-induced heart failure partly through modulation of the TNF-α/TNFR1/NF-κB signaling pathway

Shenfu injection (SFI) is widely used for heart failure (HF), but its cardioprotective mechanism remains incompletely understood. In this study, an isoproterenol-induced HF rat model, H9c2 cell injury model, network pharmacology, GEO analysis, molecular docking, and molecular dyn...

Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals

ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...

Transverse V-Y Mucosal Advancement Flap for Reconstruction of Labial Mucosal Defects: A Clinical Application

OBJECTIVE: To evaluate the clinical efficacy of the transverse V-Y advancement mucosal flap for reconstruction of small- to medium-sized lip mucosal defects. METHODS: Clinical data from 17 patients who underwent reconstruction of lip mucosal defects following resection of benign...

Imipenem and relebactam pharmacokinetics in peritoneal fluid: microdialysis reveals infection-independent penetration

species. However, data on tissue-site pharmacokinetics are limited. We evaluated the peritoneal penetration of imipenem and relebactam in healthy and infected rats by using microdialysis. The animals received a single intravenous infusion of imipenem (45 mg/kg) and relebactam (22...