Hunan University of Traditional Chinese Medicine

Effects of Brewing Temperature and Time on the Quality Attributes and Chemical Profiles of Cyclocarya paliurus Tea Infusions

Brewing temperature and duration jointly modulate the sensory perception, functional properties, and chemical composition of herbal tea infusions, yet their integrated effects on Cyclocarya paliurus tea remain poorly understood. Here, cold-brewed (4 °C) and hot-brewed (90 °C) C....

β-Boswellic Acid Suppresses Migration and Invasion and Attenuates TGF-β1-Induced EMT-Related Changes in PC-3 Prostate Cancer Cells

β-Boswellic acid (BA) has potential antitumor activity, but its effects on migration, invasion, and epithelial–mesenchymal transition (EMT)-related phenotypes in prostate cancer cells remain unclear. In this study, we integrated public transcriptomic data, candidate molecule pred...

Polygonatum sibiricum polysaccharide attenuates BMSC senescence by inhibiting NCOA4-mediated ferritinophagy

Context BMSC senescence is associated with osteoporosis progression. Polygonatum sibiricum polysaccharide (PSP) shows potential anti-senescence activity, but its effects on bone marrow mesenchymal stem cells (BMSCs) remain unclear.Objective To investigate the protective effects a...

Extract from Eucommia ulmoides Oliv. Leaves alleviates APAP-induced acute liver injury via reshaping gut microbiota and attenuating microbial bile acids metabolism disorder

Abstract Background Increasing studies suggest that supplementing flavonoids from Eucommia ulmoides Oliv. Leaves (EUL) exerts liver protective effects via reshaping gut microbiota and regulating bile acids (BAs) metabolism. However, the relationship between EUL, gut microbiota an...

Impulsivity, cognitive inflexibility, and brain network dysregulation in etomidate use disorder: A clinical and EEG microstate study

Etomidate, a short-acting GABA_A receptor modulator and emerging novel psychoactive substance, is increasingly abused non-medically. Despite rising clinical concern, the neuropsychological profiles of etomidate use disorder (EUD) remain poorly characterized, prompting this system...

Baihe Zhimu Decoction ameliorates anxious depression via PI3K / AKT / mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

BACKGROUND: Anxious depression involves severe emotional dysregulation with a high risk of relapse and suicide. Although the classical Traditional Chinese Medicine formula Baihe Zhimu Decoction (BZD) is widely used for affective disorders, its underlying mechanisms remain poorly...

Lacrimal Secretory Niche Remodeling in Dry Eye Disease: Single-Cell and Spatial Insights into Acinar Dysfunction

Reduced tear output can arise from altered neural regulation, impaired epithelial secretion, or loss of secretory tissue, with different implications for recovery. This focused narrative review integrates physiological, single-cell, spatial, organoid, and mechanistic studies iden...

Galactosylated Camptothecin (Gal-CPT) as a New Anticancer Prodrug Sequentially Activated by Dual Tumor-Specific Enzymes

Abstract Camptothecin (CPT) and its clinically used derivatives are still plagued by severe off-target toxicities. In this study, we designed a galactosylated CPT (Gal-CPT) prodrug incorporating an enzymatically cleavable diethylene glycol linker. In vivo experimental results ver...

Sodium Tetrathionate-Promoted Trisulfurative Annulation of 1,3-Diyne Diols toward Dithieno[3,2-b:2′,3′- d ]thiophenes

Abstract A sodium tetrathionate-promoted trisulfurative annulation of 1,3-diyne diols has been developed for the synthesis of polysubstituted dithieno[3,2-b:2′,3′-d]thiophenes (DTTs) in moderate to good yields. To the best of our knowledge, this represents the first use of sodium...

Spiro-Directed Hierarchical Dynamic Covalent Assembly: From Molecular Configuration to Adaptive Porous Networks

Abstract Hierarchical control over both the molecular configuration and supramolecular architecture in radical-based dynamic covalent systems remains challenging. Herein, we designed rigid spiro scaffolds fused with flexible diarylethene units as coupling linkers to regulate the...

Non-pharmacological interventions for lower limb rehabilitation after stroke: a systematic review and network meta-analysis

Stroke is a leading cause of long-term adult disability, and lower limb dysfunction substantially limits functional independence. This study aimed to systematically compare the effects of different non-pharmacological rehabilitation interventions on lower limb recovery after stro...

Parental neglect and peer victimization: stable between-adolescent co-occurrence but no significant within-person cross-lagged associations

Abstract Background Parental neglect and peer victimization often co-occur in adolescence, but this association may reflect stable between-adolescent differences or within-person temporal associations. We examined these two levels and explored whether cross-domain item associatio...

Kummerowia striata extract ameliorates polycystic ovary syndrome and associated hepatic metabolic dysfunction in mice: an integrated network-pharmacology and lipidomics study of the HIF-1α signaling axis

Context Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder in women of reproductive age and a major contributor to infertility. Kummerowia striata (Ks) is a plant of medicinal and dietary significance. Although its extract has demonstrated beneficial...

Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications

Microneedling has found various applications in dermatology recently. However, many problems still need to be solved in the fabrication of high-aspect-ratio polymeric microneedles with good mechanical strength, dimensional accuracy and thermal conductivity for energy-assisted tre...

Characterization of Escherichia Phage ND-4 Against Avian Pathogenic Escherichia coli IMT5155 and Its Preliminary Application in Chicks

Colibacillosis caused by avian pathogenic Escherichia coli (APEC) remains an important bacterial disease in poultry production and is increasingly difficult to control because of antimicrobial resistance. In this study, a lytic phage, ND-4, was isolated from poultry-farm sewage u...

Hos2-mediated KatG1 decrotonylation orchestrates ROS scavenging in rice blast infection

In plant–pathogen interaction, plants trigger reactive oxygen species (ROS) bursts to defend against pathogen invasion, while pathogens evolved antioxidant systems to scavenge ROS for infection. Our study reveals a regulatory mechanism of ROS adaptation and scavenging in the rice...

Joint associations of problematic smartphone use and cyberbullying victimization with depressive and anxiety symptoms among Chinese primary and secondary school students: a large-scale school-based study

Problematic smartphone use (PSU) and cyberbullying victimization (CBV) are independently associated with emotional problems among adolescents. However, whether their co-occurrence is associated with a greater burden of depressive and anxiety symptoms remains unclear. This study e...

Machine learning-assisted mRNA vaccine pharmacovigilance: a systematic review of multi-source real-world data

Abstract Background The rapid deployment of mRNA vaccines during the COVID-19 pandemic exposed limitations in traditional pharmacovigilance systems, including delayed reporting, high underreporting rates, and inability to calculate true incidence. Machine learning (ML) offers new...

Gut microbiota and ABC transporter pathway: potential links to the therapeutic efficacy of Shen-Ling-Bai-Zhu-San against antibiotic-associated diarrhea in juvenile rats

BACKGROUND: Shen-Ling-Bai-Zhu-San (SLBZS) recorded in the Song Dynasty text "Tai Ping Hui Min He Ji Ju Fang," is traditionally used to "strengthen the spleen, eliminate dampness and stop diarrhea." making it a commonly used prescription for treating antibiotic-associated diarrhea...

Run-length performance of AE-I and AE-II mean charts under phase-I parameter estimation

Adaptive exponentially weighted moving average charts are effective tools for detecting small-to-moderate shifts in a process mean. In practical applications, however, the incontrol mean and standard deviation are usually unknown and must be estimated from Phase I data before Pha...