Hunan University of Traditional Chinese Medicine

Effectiveness of acupuncture combined with medication for mild cognitive impairment: a systematic review and meta-analysis protocol

Abstract Introduction Cognitive impairment is a global health crisis, which reduces quality of life and adds to the socio-economic burden. Previous meta-analyses have shown that the combination of acupuncture and conventional Western medicine may offer advantages over drug therap...

Identification of Kaempferol for Skeletal Muscle Wasting in Cancer Cachexia Through Bibliometric Analysis and Network Pharmacology: Metabolomic and Experimental Evaluation

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive skeletal muscle wasting, systemic inflammation, and metabolic dysregulation. Traditional Chinese medicine (TCM) contains numerous bioactive compounds with potential multitarget effects, but systematic...

Shenfu Injection attenuates isoproterenol-induced heart failure partly through modulation of the TNF-α/TNFR1/NF-κB signaling pathway

Shenfu injection (SFI) is widely used for heart failure (HF), but its cardioprotective mechanism remains incompletely understood. In this study, an isoproterenol-induced HF rat model, H9c2 cell injury model, network pharmacology, GEO analysis, molecular docking, and molecular dyn...

Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals

ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...

Transverse V-Y Mucosal Advancement Flap for Reconstruction of Labial Mucosal Defects: A Clinical Application

OBJECTIVE: To evaluate the clinical efficacy of the transverse V-Y advancement mucosal flap for reconstruction of small- to medium-sized lip mucosal defects. METHODS: Clinical data from 17 patients who underwent reconstruction of lip mucosal defects following resection of benign...

Imipenem and relebactam pharmacokinetics in peritoneal fluid: microdialysis reveals infection-independent penetration

species. However, data on tissue-site pharmacokinetics are limited. We evaluated the peritoneal penetration of imipenem and relebactam in healthy and infected rats by using microdialysis. The animals received a single intravenous infusion of imipenem (45 mg/kg) and relebactam (22...