Human Computer Interaction (Switzerland)

Peak Shaving and Valley Filling: Reconstructing Cognitive Load in Cultural Heritage VR Through Contextualized Scaffolding

Virtual reality supports immersive cultural heritage communication, yet engagement outpaces understanding. A structural cause is that information about an object is scattered across transient carriers (NPC dialogue, annotations, triggered videos), requiring working-memory integra...

Colorectal cancer-derived IGFBP2 promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation

Colorectal cancer (CRC) liver metastasis (LM) is a leading cause of cancer-related death, with pre-metastatic niche (PMN) formation being critical for metastasis. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in metastatic CRC, but its role in intrahepati...