Hubei University

Engineering the Enzyme−Support Interface: Arginine-Directed Anchoring of Peroxygenase on a β-Ketoester Covalent Organic Framework

Controlling the conformation and orientation of enzymes at solid interfaces is a central challenge in the design of functional biohybrid materials, and the outcome depends sensitively on the chemistry and geometry of the enzyme-support interface. Here, a β-ketoester-functionalize...

Organoid‐Driven Open‐Flow Artificial Vessels Inspired by Insect Dorsal Vessel Circulation

ABSTRACT Embedding functional fluid transport into living biohybrid devices remains a critical bottleneck for next‐generation engineered living systems. Conventional strategies rely on external pumps or sealed microfluidic structures, restricting biological compatibility and tiss...

A phase II trial of chemotherapy-free neoadjuvant camrelizumab plus apatinib for resectable HNSCC: pathological response and vascular-immune crosstalk

Abstract Purpose: To evaluate the efficacy, safety, and tumour microenvironment remodelling of neoadjuvant camrelizumab plus apatinib in resectable head and neck squamous cell carcinoma (HNSCC; stage II–IVA). Materials and Methods: In this single-arm, exploratory phase II trial (...

Nonlinear dynamics and susceptible spiking of threshold-switching Hodgkin–Huxley neurons

With the development of neuromorphic computing, threshold-switching devices have been widely explored for implementing artificial neurons, but the stability of such circuits remains a critical challenge. This work systematically investigates the Hodgkin–Huxley (HH) neuron based o...

Multi-Scenario Simulation of Land-Use Change and Its Impacts on Ecosystem Services in Hubei Province, China

Land-use change is a primary driver of changes in ecosystem services, and different development scenarios imply markedly different ecological responses, with consequences for regional economic development and ecological protection. However, existing studies have mostly focused on...

Heart failure may promote breast cancer progression through a Col10a1-associated Tgf-β/Smad-EMT pathway

Heart failure (HF) is clinically associated with aggravated breast cancer (BC) progression; however, the integrative genomic mechanisms underlying this cardio-oncological crosstalk remain poorly understood. We conducted integrative bioinformatics analyses combining weighted gene...

Programming Hydrogel Release Kinetics to Tissue Healing Phases: From Network Design to Therapeutic Synchronization

The sequential phases of tissue healing—inflammation, proliferation, and remodeling—demand distinct pharmacokinetic profiles that conventional drug delivery systems fail to provide, creating a “chronotherapy gap” that contributes to chronic wound pathologies. Hydrogels, with thei...

Integrated O 2 and H 2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

ABSTRACT Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle‐assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies...

A cascaded deep learning framework for improved forecasting of drought-flood abrupt alternation events in the Hanjiang River Basin

Study region The Hanjiang River Basin (HJRB), a meteorologically and topographically complex region in China. Study focus Drought-Flood Abrupt Alternation (DFAA) events threaten water security, yet their prediction remains challenging because of highly nonlinear dynamics and pron...

The relationship between parental mediation and problematic internet use among adolescents: roles of hiding online behaviors and autonomy

Abstract Background In a modern information society, problematic internet use among adolescents poses challenges to family education, and research on the effects of parental mediation has yielded inconsistent findings. To explore the possible pathways underlying these association...

SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiac dysfunction and mortality worldwide. Serine/arginine-Rich Protein Kinase 3 (SRPK3) is highly expressed in cardiac muscle, yet its specific pathological role in I/R injury has not been fully characteri...

Motion enhances camouflage: Retinal evidence for flicker fusion camouflage in jumping spiders

Camouflage is often assumed to fail once prey move, yet theory predicts that rapid motion can reduce detectability through flicker fusion camouflage (FFC), where high-contrast patterns blur into perceptual uniformity. We tested this prediction using retinal tracking in the jumpin...

Nutrient–Microbiota Co-Regulation of Protein Conversion in Black Soldier Fly Larvae: The Role of Alkali-Soluble Protein and Gut Microbial Communities

Insect protein farming provides sustainable advantages in land efficiency, emission reduction, and bioconversion. A major challenge is optimizing nutrient composition to achieve cost-effective protein production. This study investigates the co-regulatory mechanism between alkali-...

A One-Pot Reverse Transcriptase-Mediated, Pre-amplification-Free CRISPR/Cas12a Assay for Ultrasensitive Nucleic Acid Detection

Abstract CRISPR/Cas12a holds great promise for biosensing and diagnostics, but conventional methods suffer from low catalytic efficiency, high background, and reliance on pre-amplification. Direct detection of structured RNAs also remains challenging. Herein, we report the develo...

Alkali Metal Ion Migration Modulation-Induced High-Performance Low-Temperature Solid Oxide Fuel Cells

Abstract Reducing the operating temperature while maintaining a stable performance is a key challenge for solid oxide fuel cells (SOFCs). Here, we improve the performance of low-temperature SOFCs by modulating the migration of alkali metal ions within the cell. To visualize the m...

BifunctionalIonophores for Cuproptosis Activation:Dual Targeting of Copper and Fe–S Protein Homeostasis

Abstract Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron–sulfur (Fe–S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe–S cluster homeostasis,...

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-...

Numerical simulation on full-link underwater LIDAR with an optical filter using OAM modulation

Optical filtering based on orbital angular momentum (OAM) modulation can effectively suppress background noise and multiple-scattering light in water, thereby improving the signal-to-noise ratio (SNR) of underwater lidar. Although OAM modulation has been investigated in previous...

Leg Autotomy and Regeneration in Crab Spiders Ebrechtella tricuspidata (Araneae: Thomisidae)

Arachnids evade predation by intentionally sacrificing body parts, with leg autotomy playing a crucial role in their survival and reproductive strategies. Our study primarily employed field surveys and laboratory experiments to examine the frequency of autotomy and its effects on...

Photothermal Superhydrophobic Textiles: An Emerging Paradigm from Passive Water Repellency to Active Thermal Management

Photothermal superhydrophobic textiles represent an emerging paradigm integrating active light-driven functionality with passive liquid repellency. While previous reviews treated superhydrophobicity and photothermal effects in isolation, this work pioneers a systematic analysis o...