Hubei University

Nuclear BbAtg8 interacts with BbMac1 as a transcriptional modulator to sustain nuclear copper homeostasis during conidial germination

Pathogenic fungi endure host impose copper starvation by tightly coordinating trace metal homeostasis. However, how pathogens synchronize endogenous metal recycling with exogenous copper uptake to promote infection remains enigmatic. Using the entomopathogenic fungus Beauveria ba...

Coupled convection–radiation heat transfer and optimization in microscale fin structures

With the increasing power density of electronic devices, effective thermal management is essential for maintaining performance and reliability. Although air-cooled heat sinks have been extensively investigated, studies have primarily focused on structural optimization and convect...

PROTAC-Loaded Nanoparticles Induce a “ROS Storm” through Targeted Degradation of GPX4 in Combination with a Mild Photothermal/Fenton-like Reaction for the Treatment of Triple-Negative Breast Cancer

Abstract Proteolysis-targeting chimeras (PROTACs) are a promising therapeutic approach for degrading disease-causing proteins. However, they often encounter limitations in in vivo applications due to poor solubility, low cellular permeability, unfavorable pharmacokinetics, and mo...

LSTM-based prediction and parameter optimization analysis of sandstone subgrade compaction quality

The study proposes an LSTM-based framework for next-pass Compaction Energy Value (CEV) prediction and subsequent energy planning during sandstone subgrade compaction. Field tests were conducted at two sites, each divided into 24 spatial areas. For each completed compaction pass,...

Pioneering MOF-303 in Lithium–Sulfur Batteries: Coordination Defect Engineering Enables Accelerated Sulfur Redox and Dendrite-Free Plating

Abstract Lithium–sulfur (Li–S) batteries are severely hindered by the shuttle effect of lithium polysulfides (LiPSs) and uncontrolled lithium dendrite growth. Herein, a defect-engineered MOF-303 (D-MOF-303) modified separator is developed via a ball-milling strategy to simultaneo...

Mussel-Mimetic Polyethylene Glycol–Protocatechualdehyde-Modified Polysiloxane Dressing for Wound Healing

Abstract Wound damage caused by dressing–wound adhesion during removal remains a common clinical complication. Polysiloxane dressings offer the advantage of low irritation during removal; however, their practical application remains restricted by poor adhesive performance and phy...

Synthesis of 2,5-bis(hydroxymethyl)furan and furan-2,5-diylbis(methylene) diacetate from apple pomace waste via chemobiological catalysis

The direct valorization of real agricultural waste into high-value furan derivatives remains challenging because biomass deconstruction and selective downstream upgrading generally require chemically distinct catalytic environments. Here, a sequential chemobiological platform int...

Honeydew‐Associated Bacteria Suppress Zucchini Defense Responses and Enhance the Performance of the Cotton‐Melon Aphid

Aphid honeydew is generally regarded as a sugar-rich excretion, but it also contains microbial communities that may influence plant-herbivore interactions. Whether honeydew-associated bacteria suppress plant defense responses to enhance aphid performance remains unclear. Here, we...

Realization of Quantum Spin Hall Insulator Superlattice with Emergent Multigap‐Like Helical Edge States

ABSTRACT The functional quantum spin Hall insulators (QSHI), protected by time‐reversal symmetry against single‐particle backscattering, hold great promise for dissipationless quantum electronics. Realization of QSHI with gapped helical edge states, which would enable determinist...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

A Selective ERα Photodegrader for Precise and Efficient Breast Cancer Treatment

Abstract Breast cancer is the most prevalent malignancy in women, with over 70% of cases being estrogen receptor α (ERα)-positive. Photodynamic therapy (PDT) is spatially precise yet limited by tumor-selective photosensitizers. Herein, we report the first co-crystal structure of...

Polarized light and size control in modulating the photothermal performance of titanium nitride nanobipyramid

Plasmonic nanostructures have received considerable attention for solar photothermal conversion due to their strong light absorption and efficient heat generation. However, conventional noble-metal plasmonic materials suffer from high cost, limited thermal stability, and inadequa...

心理资本视角下农村留守儿童学业抗逆力提升的干预研究——基于中国某乡镇小学的混合方法研究

农村留守儿童的心理健康与学业发展是当前教育研究的重要议题，部分留守儿童出现以沉默退缩、沟通封闭为主要特征的拒学行为，严重制约其学业发展。本研究从心理资本理论视角出发，以某乡镇小学32名具有“沉默型拒学”特征的留守儿童为对象，采用混合研究方法（问卷调查、半结构化访谈和准实验设计），探究...

Nomograms based on clinical characteristics and baseline dual-layer spectral detector computed tomography imaging parameters: potential clinical utility in predicting the efficacy of first-line lymphoma treatment

Abstract Background Spectral computed tomography (CT) is considered a useful tool for predicting tumor treatment response and survival. However, its role in lymphoma treatment remains unclear. The purpose of this study was to develop spectral CT-based nomogram for predicting resp...

Mechanistic insights into VSIR-mediated AXL regulation and gastric cancer proliferation

Gastric cancer (GC) progression is frequently driven by complex tumor microenvironment signals. Here, our study identifies V-set immunoregulatory receptor (VSIR) as a key driver of GC progression via AXL regulation. High-throughput RNA sequencing demonstrated that VSIR overexpres...

Disturbance-Driven Reactive Oxygen Species Generation Promotes Organic Carbon Mineralization in Sediments of Lake Taihu

Abstract Lake sediments are prone to disturbance from anthropogenic and natural processes, inducing O2 intrusion that can generate reactive oxygen species (ROS). However, the occurrence and accumulation of ROS production in O2-perturbed lake sediments are poorly documented. Herei...

Sb3+ Doping-Induced Coordination Competition and Host-Guest Reversal in In-Based Metal Halides

Abstract Sb3+-doped In-based metal halides represent a class of highly efficient luminescent materials; however, systematic studies on the effects of Sb3+ doping on the coordination-structure evolution and photophysical-property changes of In-based metal halides remain limited. H...

When plateware shape matters: The congruence effects between food pungency and plateware shape on food preference

Although considerable attention has been paid to enhancing the visual appeal of food, less is known about how plateware design should align with the sensory characteristics of food. Drawing on shape-taste correspondence research and processing fluency theory, this research examin...

Surface Plasmon Polaritons Enable Reaction‐Specific Energy Transduction for Molecular Ionization and Isomer Discrimination

ABSTRACT Efficient and controllable conversion of optical energy into chemical energy at interfaces remains a fundamental challenge in photochemistry and catalysis. Here we show that surface plasmon polaritons (SPPs) enable reaction‐specific energy transduction for molecular ioni...

Engineering the Enzyme−Support Interface: Arginine-Directed Anchoring of Peroxygenase on a β-Ketoester Covalent Organic Framework

Controlling the conformation and orientation of enzymes at solid interfaces is a central challenge in the design of functional biohybrid materials, and the outcome depends sensitively on the chemistry and geometry of the enzyme-support interface. Here, a β-ketoester-functionalize...