Huashan Hospital

A Machine Learning Model With Temporal Validation for Predicting Walking Ability in Nontraumatic Spinal Cord Injury

BACKGROUND: Walking ability is the priority for spinal cord injury (SCI) patients. Nontraumatic SCI (NTSCI) is increasing with aging populations, yet its prognosis remains understudied. Early predictionF using admission clinical indicators could facilitate decision-making and reh...

Virological Events During Immune Checkpoint Inhibitor Therapy: A Multi-Source Evaluation

Background/Objectives: Virological findings during immune checkpoint inhibitor (ICI) therapy may represent viral loss of control, pre-existing infection, tumour biomarkers, or infection after immune-related adverse event (irAE)-directed immunosuppression. Distinguishing these pos...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression

Objectives The role of the sympathetic neurotransmitter norepinephrine (NE) in ulcerative colitis (UC) remains controversial. We aimed to elucidate NE's precise mechanisms in UC, focusing on colonic metabolism, diagnostic potential, and local immune interactions. Methods Colonic...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Targeting the ENO1 metabolic checkpoint via microenvironment-responsive nanotherapeutics promotes postinfarction cardiac repair

Myocardial infarction (MI) triggers persistent inflammatory dysregulation, wherein macrophages undergo glycolytic reprogramming and adopt an inflammatory phenotype that impairs cardiac repair. However, the specific metabolic drivers underlying post-MI macrophage dysfunction remai...

Large-scale genetic profiling of hereditary ataxias in China: implications for a stepwise molecular diagnostic strategy

BACKGROUND: Hereditary ataxias are clinically and genetically heterogeneous, which complicates clinical management, genetic counseling, and scientific research. Efficient molecular diagnosis is essential but requires molecular epidemiological considerations due to the variable ge...

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...

AI-assisted preoperative anesthesia evaluation workflow versus conventional bedside evaluation: a randomized controlled non-inferiority trial

Abstract Background Digital tools may improve the efficiency and standardization of preoperative anesthesia assessment, but evidence comparing AI-assisted workflows with conventional bedside evaluation remains limited. We compared ASA physical status classification concordance, d...

Age-related changes of FCGR3A+ natural killer cells and their association with elderly atopic dermatitis

Background The increasing global ageing population has led to a rising prevalence of elderly atopic dermatitis (eAD). Natural killer (NK) cells play an important role in skin homoeostasis; however, their involvement in eAD remains unclear. This study investigates the functional r...

Classification-aware conditional diffusion-augmented criss-cross graph transformer for EEG-based emotion recognition

Reliable electroencephalogram (EEG)-based emotion recognition remains challenging because labeled recordings are limited, noisy, non-stationary, and strongly subject dependent. This paper proposes a classification-aware conditional diffusion-augmented criss-cross graph transforme...

β‐ TP For Diagnosing CSF Leak After the Endoscopic Endonasal Approach Surgery for Sellar Tumors

ABSTRACT Objectives This study aimed to evaluate the diagnostic utility of quantitative beta‐trace protein (β‐TP) as an early biomarker for identifying postoperative cerebrospinal fluid (CSF) leaks following endoscopic endonasal approach (EEA) surgery for sellar tumors. Methods A...

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Abstract Despite improved survival rates with dual trastuzumab and pertuzumab therapy, patients with HER2-positive breast cancer frequently experience disease progression due to intrinsic or acquired resistance. Elucidating the underlying mechanisms of resistance and identifying...

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

Background Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood. Objective To elucidate the metabolic and molecular programmes t...

Microbial architects of the lung tumor niche: integrating intratumoral and lung cancer-associated microbiome

Lung cancer (LC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Increasing evidence suggests that both the lung cancer-associated microbiome and the intratumoral microbiome are important components of the tumor ecosystem and contribute to c...

Early inflammatory response is associated with antibiotic treatment outcomes in acute phlegmonous appendicitis: a retrospective cohort study

Acute phlegmonous appendicitis is considered an intermediate inflammatory subtype between uncomplicated and complicated appendicitis. Although nonoperative management is increasingly accepted for uncomplicated appendicitis, evidence for phlegmonous appendicitis remains limited. T...

The 2025 CHINET surveillance report on bacterial resistance in China

Abstract This study assessed the antimicrobial susceptibility of clinical bacterial isolates collected from Chinese medical institutions in 2025. Antimicrobial susceptibility testing was performed on isolates from 80 hospitals using disk diffusion or commercial automated systems...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...