Huashan Hospital

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Language-enhanced generative modeling for amyloid PET synthesis from MRI and blood biomarkers.

Assessment of amyloid pathology in Alzheimer's disease (AD) often relies on amyloid-beta positron emission tomography (Aβ-PET), but its clinical use is limited by cost and accessibility. We developed a language-enhanced generative framework to synthesize Aβ-PET images from T1-wei...

Pressure-gated flexible nanofluidic memristor based on a probe-punctured PDMS membrane

A flexible nanofluidic memristor is demonstrated based on a polydimethylsiloxane (PDMS) membrane containing a single nanopore formed by probe puncturing and controlled by external pressure. A PDMS prepolymer with a base-to-curing agent ratio of 10:1 is cast and cured into a thin,...

Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis

Purpose: This study investigated the molecular mechanisms underlying blue light-induced corneal epithelial toxicity. Methods: C57BL/6J mice were exposed to 460 nm blue light for 1, 2, or 4 weeks, whereas human corneal epithelial (HCE) cells were exposed for 15 or 30 min. RNA-sequ...

Targeted biologics in muscle strength restoration and corticosteroid sparing for patients post-myasthenic crisis

Myasthenic crisis (MC) represents a life-threatening condition in patients with myasthenia gravis (MG). Despite a substantial reduction in in-hospital mortality for MC, full restoration of muscle strength and quality of life usually requires months or years. It remains unknown wh...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

AI-Assisted Viable Digital Array for Rapid Quantification of Bacteria in Pediatric Urinary Tract Infections

Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in neonates and infants, and delayed diagnosis can lead to severe complications. Rapid, quantitative detection of viable bacteria at the point of care remains a critical unmet need. Here, we p...

Preoperative HbA1c and postoperative day 1 fasting plasma glucose are associated with early glycemic improvement after transsphenoidal surgery in patients with acromegaly and preoperative dysglycemia: a retrospective cohort study

Dysglycemia is common in acromegaly and may improve after transsphenoidal surgery, but factors associated with early postoperative glycemic improvement are unclear. We aimed to identify perioperative factors associated with glycemic improvement at first follow-up, focusing on pre...