Huaian First People’s Hospital

Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is characterized by progressive podocyte loss and cellular senescence, but the upstream stress pathways that determine podocyte fate are not fully understood. YME1L expression was markedly reduced in experimental models of DKD and was inversely assoc...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Multi-omics insights into the mechanisms and prognosis of IPF

Abstract Idiopathic pulmonary fibrosis (IPF) represents another progressive and devastating interstitial lung disease found across populations, with a prominent male predominance accounting for approximately 70% of cases. Regional variation in IPF-related genetic polymorphisms, e...

Analysis of barriers to self-monitoring of blood glucose among community-dwelling elderly patients with diabetes mellitus: a cross-sectional study integrating artificial intelligence-based risk prediction

Self-monitoring of blood glucose (SMBG) is essential for diabetes management, yet elderly patients face multiple barriers that compromise adherence and glycaemic control. This study aimed to assess barriers to SMBG among community-dwelling elderly patients with diabetes mellitus,...

Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained increasing attention due to its involvement in lipid metabolism and neuroinflammation regulation. High PCSK9 levels are linked to an elevated risk of cerebrovascular events and small vessel diseases. However, system...