Hospital of the University of Pennsylvania

Decade-long persistence of CD19 CAR T cells in B cell lymphomas

Abstract Chimeric antigen receptor (CAR) T cell therapy induces durable remissions in lymphoid malignancies, yet the extent and biology of long-term CAR T cell persistence in B cell lymphoma remain unclear. Here we report the persistence and characteristics of 4-1BB-costimulated...

Addressing Medical Neglect in Children With Complex Chronic Conditions

In this issue of Pediatrics, Cleveland et al report a cross-sectional analysis of a 2-state, multiyear database of linked child protective services (CPS) and Medicaid claims data to characterize the prevalence and associations of complex chronic condition (CCC) status across CPS...