Hospital Nacional de Parapléjicos

Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair

The development of bioengineered conduits for the repair of large peripheral nerve defects remains challenging. Here, we introduce a biomimetic fibrin hydrogel scaffold containing stacked arrays of aligned poly(ε-caprolactone) (PCL) nanofibers that mimics the naturally forming fi...

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state

The pathophysiological mechanisms underlying the hypercoagulable state and thrombotic events associated with COVID-19 remain incompletely understood. To investigate prothrombotic alterations during SARS-CoV-2 infection, we performed an exploratory and integrated analysis of cereb...