Hospital Kuala Lumpur

Safety and efficacy of non-medical switch from innovator to generic tofacitinib: a 3-month observational study in rheumatoid arthritis patients

Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation. Following the expiry of the patent for innovator tofacitinib (Xeljanz), generic tofacitinib formulations such as Tozib have become available. This study evaluated the impact of...

Combined Maximum Tolerated Activity and Lesion-based Dosimetry for Personalized Radioiodine Therapy in Metastatic Differentiated Thyroid Carcinoma: An Early Institutional Experience

Objectives: Empirical fixed-activity radioiodine (RAI) therapy remains widely used in differentiated thyroid carcinoma (DTC), despite substantial inter-patient variability in iodine kinetics. Pre-therapeutic dosimetry offers a personalised approach by estimating radiation exposur...

Optimizing care delivery models for persons with chronic kidney disease

PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a growing healthcare burden globally, driven by increasing incidences of diabetes mellitus and hypertension. With an ageing population and attrition of nephrology workforce, managing CKD has become challenging across multiple hea...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

How Long and How We Judge Age: A Cross-Racial and Cross-Gender Eye-Tracking Investigation

Abstract Background Facial aging results from genetic, environmental, and lifestyle factors, leading to wrinkles, volume loss, and contour changes. These alterations affect perceived age, attractiveness, and self-image. Eye-tracking technology provides insights into gaze patterns...

Optimisation of a polyvinyl alcohol–silver nitrate color dosimeter for 3D dose measurement in clinical radiotherapy

This study aims to optimize a polyvinyl alcohol–silver nitrate (PVA/AgNO 3 ) color dosimeter for potential application in three-dimensional (3D) dose verification in clinical radiotherapy. Formulations comprising varying concentrations of PVA (70%, 80%, 90%) and silver nitrate (1...

A decade later: a longitudinal retrospective cohort study of the clinical course of childhood-onset epilepsy in a multi-ethnic tertiary centre

Abstract Background Epilepsy affects a significant proportion of people globally, with many cases beginning in childhood. However, there is a lack of longitudinal studies exploring the long-term outcomes and characteristics of childhood-onset epilepsy into adulthood. This study a...

A qualitative study on feeding experiences among caregivers of children with cerebral palsy requiring food texture modification

Background and purpose Children with cerebral palsy often experience feeding difficulties that require food texture modification and are highly dependent on their caregivers, which commonly lead to malnutrition. This study aimed to explore caregiver's current practices, perceptio...

Medical adhesive-related skin injury: Prevalence, risk factors, prevention and mitigation. A systematised literature review

Background: Medical adhesives are widely used, and have an invaluable role in securing medical devices and management of wounds. However, medical adhesive-related skin injuries (MARSI) are a common occurrence and adversely affect patient and provider outcomes. Methods: A systemis...

Homologous Recombination Deficiency (HRD) and BRCA oncogenic variants in newly diagnosed advanced Epithelial Ovarian Cancer (EOC): first report among multi-ethnic patients

Ovarian cancer patients with homologous recombination deficiencies (HRD) exhibit specific clinical behaviours and improved responses to platinum-based chemotherapy and poly (ADP-ribose) polymerase treatment. HRD-positive patients are characterised by having genomic scar score (GS...

The Potential Role of Amyloid Precursor Protein Fragments as a Screening Tool for Mild Cognitive Impairment

ABSTRACT Background Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, in which early detection is essential. Urinary amyloid precursor protein (APP) fragments have been proposed as a non‐invasive biomarker, but their diagnostic value in el...

Single-use bronchoscopes in contemporary respiratory practice: current evidence and clinical applications

Abstract This narrative review examines the evolving role of single-use flexible bronchoscopes (SUFBs) in contemporary respiratory medicine. SUFBs have become an increasingly important part of respiratory practice, particularly following the COVID-19 pandemic, which highlighted t...