Institution
Hospital for Sick Children
Recent research
- Health & MedicineOpen access
Abstract Objective Although the centromedian nucleus of the thalamus (CM) is an increasingly considered deep brain stimulation (DBS) target for drug‐resistant epilepsy (DRE), there is significant variability in programming practices, which may contribute to heterogenous outcomes....
- Health & MedicineOpen access
Background Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of l...
- Health & Medicine
Congenital Tuberculosis in a 2-Week-Old Neonate With an Asymptomatic Mother
Congenital tuberculosis (TB) is a rare condition, and diagnosis is challenging due to its nonspecific clinical presentation and rarity. It has a very high case-fatality rate (estimated at 30%–50%). We report the case of a 2-week-old male neonate, born from an uncomplicated diamni...
- Health & MedicineOpen access
Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...
- Climate & EnvironmentOpen access
<title>Abstract</title> <bold>Background:</bold> Urbanization is spatially heterogeneous in many sub-Saharan African settings. This complicates community health planning when rural and peri-urban labels are applied informally or updated inconsistently. We assessed whether multipl...
- Health & Medicine
The Association Between Intranasal Steroids and Length of Stay in Children With Orbital Infections
OBJECTIVE: Little is known about the use of intranasal agents in the management of orbital infections in children. This study aims to describe intranasal corticosteroid use in children hospitalized with orbital infections and to determine whether an association exists between int...
- Health & Medicine
BACKGROUND: Timing of clean intermittent catheterization (CIC) in infants with neurogenic lower urinary tract dysfunction (NLUTD) remains uncertain. We compared 12-month infectious and renal-bladder ultrasound (RBUS) outcomes in infants started on CIC within 30 days of life versu...
- Biology
The dynamic and heterogeneous structure of the non-canonical inflammasome
Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to protect against cellular stresses such as pathogenic bacteria. Both canonical and non-canonical inflammasomes have been described in the l...
- Health & MedicineOpen access
A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders
BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...
- Health & Medicine
Objectives Sex disparities exist in the receipt of total knee arthroplasty (TKA) for osteoarthritis (OA), with females disproportionately less likely to undergo surgery. Understanding the reasons for this gap is critical for equitable health care delivery. Lower willingness to un...
- Health & Medicine
Objectives We aimed to investigate the performance characteristics of the new European Alliance of Associations for Rheumatology (EULAR) /American College of Rheumatology (ACR) classification criteria for pediatric CNO, in a distinct real-world clinical setting and compare it to...
- Biology
Cryptic NLRP3 Mosaicism Uncovered by Deep Sequencing in Muckle-Wells Syndrome: A Case Report
Background Muckle-Wells syndrome is part of the cryopyrin-associated periodic syndrome (CAPS) family, a group of rare autoinflammatory conditions caused by gain-of-function variants in the NLRP3 gene, leading to uncontrolled activation of the inflammasome and excessive IL-1β rele...
- Health & Medicine
Objectives Myocarditis is an acute inflammatory process of the myocardium characterized by impaired contractile function. The incidence is 1-2 cases/100,000 children, but it has increased since 2020 due to Pediatric Multisystem Inflammatory Syndrome (MIS-C). The pathogenesis invo...
- Health & Medicine
Objectives Autoimmune congenital heart block (CHB) has been associated with maternal autoimmune disease for a century, particularly in lupus and Sjögren’s disease pregnancies. Although 80+% of affected pregnancies are anti-Ro positive, CHB develops in only 1 in 50 such pregnancie...
- Health & Medicine
A Novel Approach to Monitoring Calcinosis in Juvenile Dermatomyositis: Serial Low-Dose Whole-Body CT
Objectives Evaluating the overall impact of calcinosis and response to therapy in juvenile dermatomyositis (JDM) remains challenging, primarily relying on physician assessments or plain X-rays.[1] We aimed to explore the use of an ultra-low-dose protocol for whole-body CT imaging...
- Health & Medicine
Objectives To explore the mental health impact and care needs of youth living with Juvenile Spondyloarthritis (JSpA) from the perspective of patients and caregivers. Methods Participants aged 12-18 years with a JSpA diagnosis and their caregivers were recruited in person through...