Hospital de São João

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Orbital Apex Involvement in Sinonasal Intestinal-Type Adenocarcinoma: Impact on Distant Metastasis and Mortality

Abstract Sinonasal intestinal-type adenocarcinoma (ITAC) is often diagnosed at advanced stages. Prognosis is strongly influenced by tumor extension into critical anatomical regions contiguous with the orbit and skull base, where achieving negative margins is challenging. To ident...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Artificial Intelligence and AI-Adjacent Digital Technologies in Nursing Practice Within Gastroenterology: A Scoping Review of Current Applications, Challenges, and Future Directions

Background/Objectives: Artificial intelligence (AI) is increasingly integrated into clinical gastroenterology, with emerging applications in nursing contexts. However, the extent and nature of these applications in gastroenterology nursing remain under-explored. This scoping revi...

Metabolic dysfunction in chronic critical illness: mechanisms, clinical consequences and therapeutic perspectives

Advances in intensive care have improved survival from acute critical illness, leading to a growing population of patients with chronic critical illness (CCI), many of whom require prolonged organ support. This condition is associated with persistent catabolism, inflammation, and...

Advanced Echocardiography and Myocardial Work in Idiopathic Carpal Tunnel Syndrome with Presumptive Concurrent Cardiac Amyloidosis: An Exploratory Cross-Sectional Study

Background/Objectives: Idiopathic carpal tunnel syndrome (CTS) can frequently precede the clinical diagnosis of transthyretin cardiac amyloidosis (ATTR-CA). This study aimed to comprehensively characterize the standard and advanced echocardiographic phenotype in a screening cohor...

Proenkephalin/penKid in renal dysfunction: An integrative review of laboratory and clinical evidence

Proenkephalin A 119–159 (PENK/penKid) is a circulating peptide increasingly investigated as a functional biomarker of glomerular filtration and acute kidney dysfunction. This integrative review critically examines diagnostic, prognostic, analytical, and implementation evidence re...

Core components of transitional care for ECMO survivors after ICU discharge: a three-round modified Delphi study

Background Survivors of extracorporeal membrane oxygenation (ECMO) may experience persistent physical, cognitive, psychological, social, and quality-of-life impairments after intensive care unit (ICU) discharge. However, the core components of early transitional care after ECMO r...

Clinical Outcomes of Patients Ineligible for Arteriovenous Vascular Access: A Retrospective Cohort Analysis

ABSTRACT Background A subset of patients with advanced chronic kidney disease (CKD) or kidney replacement therapy becomes ineligible for arteriovenous vascular access creation due to vascular exhaustion or comorbidity‐driven contraindications. Outcomes following a negative surgic...

Myeloma Elderly Prognostic Score ( MEPS ): A Proposed Prognostic Score Integrating Age, Renal Function, Performance Status, and Ultra‐High‐Risk Cytogenetics

Established disease-centered prognostic systems may be less tailored to elderly/non-transplant-eligible (NTE) patients with multiple myeloma (MM), in whom host-related factors such as age, performance status, and renal function strongly influence all-cause outcomes. We developed...

Nature-Based Solutions for Office Workers: A Randomized Controlled Trial on Indoor Plants to Enhance Well-Being and Productivity

Most of the global population lives and/or works in urban areas with limited access to green spaces. Integrating nature-based solutions (NBS) into indoor environments has emerged as a promising intervention strategy for enhancing indoor environmental quality (IEQ) and promoting h...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

Exploring the relation between childhood adversity and diabetes medication adherence: a cross-sectional study

Adverse Childhood Experiences (ACE) are associated with poor health outcomes, but their effect on the medication adherence of patients with type 2 diabetes (T2DM) remains unclear. This study aimed to assess the relation between ACE and medication adherence, while also exploring w...

Real-World Safety Profile of Adjuvant Abemaciclib in HR+/HER2− Early Breast Cancer

Background/Objectives: Treatment with adjuvant abemaciclib plus endocrine therapy (ET) has been demonstrated to improve outcomes in patients with HR+/HER2- early breast cancer at high risk of recurrence. However, real-world data regarding abemaciclib tolerability and treatment ma...