Hospital de Sant Pau

Artificial intelligence‐assisted categorization of interictal abnormalities in adult long‐term electroencephalographic monitoring: Comparable diagnostic accuracy with marked efficiency gain

Abstract Objective Artificial intelligence (AI) classifies routine electroencephalograms (EEGs) with expert‐level accuracy, but interpretation of long‐term EEG monitoring (LTM) remains reliant on time‐intensive visual review. We evaluated whether autoSCORE, a clinically approved...

A CXCR4-Targeted Dual-Acting Nanoconjugate Combines Protein-Toxin and Small-Molecule Warheads for Synergistic Cytotoxicity

Abstract Self-assembling multivalent protein nanoparticles with an architecture based on His-metal coordination and specific binding to cancer stem cells have emerged as promising tools for the selective delivery of microbial toxins in oncology, reaching precise cytotoxic effects...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Sex-related differences in clinical characteristics, management, and outcomes of Enterococcus faecalis bloodstream infection

OBJECTIVES: To evaluate whether clinical characteristics and outcomes of patients with Enterococcus faecalis bloodstream infection (EF-BSI) differ by biological sex. METHODS: Quasi-experimental study conducted at two hospitals, comprising a retrospective phase (2017-2019) and a p...

Invasive Bacterial Infections Other Than Escherichia coli and Streptococcus agalactiae in Febrile Infants Younger Than 90 Days

BACKGROUND: Invasive bacterial infections (IBIs) in febrile infants ≤90 days are mostly caused by Escherichia coli and Streptococcus agalactiae. However, data on IBIs caused by other pathogens remain limited. METHODS: We conducted a multicenter retrospective study of febrile infa...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

Abstract Background White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue C...

Mediterranean lifestyle and risk of recurrent cardiovascular events: a prospective study from the UK biobank

Abstract Background The Mediterranean Lifestyle Index (MEDLIFE) evaluates adherence to traditional Mediterranean living, encompassing diet, physical activity, rest and conviviality. Although it has been linked to reduced risk of cardiovascular disease (CVD), diabetes, and other c...

Recent and long-term glycation markers and asymptomatic cerebral microangiopathy in adults without diabetes: the ILERVAS study

Cerebral microangiopathy encompasses a spectrum of pathological alterations affecting the brain microvasculature. Elevated glycated haemoglobin (HbA1c), a marker of recent glycemic exposure, has been associated with a greater burden of subclinical atherosclerosis in the carotid a...

Reappraisal of Cisplatin vs Carboplatin Treatment for Solid Tumors

Importance Cisplatin and carboplatin are central pillars of chemotherapy in solid tumor oncology, but their comparative efficacy and tolerability remain variably defined in the literature across tumor types and settings. Objective To quantify and grade the certainty of evidence c...

Hypofractionation in Unresectable Stage II-III NSCLC: A Systematic Technical Review and Practical Recommendations

Background: Concurrent chemoradiotherapy (cCRT) followed by 1 year of consolidation durvalumab remains the standard of care for unresectable stage III non-small cell lung cancer (NSCLC), yet long-term survival is still limited and around 20% of patients present locoregional relap...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Myeloid-Derived Suppressor Cells (MDSCs) in Cardiovascular Risk of Obesity-Associated Diabetes

The dysregulation of immune homeostasis and the persistence of chronic, low-grade inflammation represent core pathophysiological drivers governing the onset and progression of metabolic and cardiovascular disorders. Myeloid-derived suppressor cells (MDSCs) comprise a highly heter...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Hallux Valgus, Not Hallux Abductus Valgus: A Short Report on Historical and Anatomical Terminology

Background: This short report argues that the term “hallux abductus valgus” is anatomically inconsistent and should be replaced by “hallux valgus.” Hallux valgus describes a lateral deviation of the great toe with a medial deviation of the first metatarsal. Although the deformity...

Clinical Variability and Genotype‐Driven Outcomes in CHRND ‐Related Congenital Myasthenic Syndrome

BACKGROUND: Congenital myasthenic syndromes (CMS) caused by pathogenic variants in CHRND, encoding the δ-subunit of the nicotinic acetylcholine receptor (AChR), are rare, and data on genotype-phenotype correlations and long-term outcomes are limited. METHODS: We performed a retro...

LINC00152 is a lncRNA modulated by microenvironmental stimuli that has pathogenetic and clinical relevance in CLL

Abstract Chronic lymphocytic leukemia (CLL) is a common lymphoid neoplasm with heterogeneous biological features and clinical behavior, influenced by acquired genetic alterations and microenvironment interactions. We explored non-coding RNAs expression to understand their role in...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...