Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Diagnostic strategies for the detection of Sarcocystis spp. and Toxoplasma gondii in bovine hearts from São Paulo, Brazil

Abstract Foodborne parasitic zoonoses such as toxoplasmosis and sarcocystosis represent a public health challenge and an economic loss in the beef production chain, a sector in which Brazil lacks a specific laboratory monitoring program. This study aimed to detect Sarcocystis spp...

Cracking the Code of CPAP Leak

Pedro R Genta, Geraldo Lorenzi-Filho; Cracking the Code of CPAP Leak, Annals of the American Thoracic Society, , aaoag278, https://doi.org/10.1093/annalsat

Data distribution impacts the performance and generalisability of contrastive learning-based foundation models of electrocardiograms

Contrastive learning is a widely adopted self-supervised pretraining strategy, yet its dependence on cohort composition remains underexplored. We present Contrasting by Augmented Patient Electrocardiograms (CAPE) foundation model and pretrain on four cohorts (n = 5,203,269), from...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Prognostic factors for mortality and recurrence after radical nephroureterectomy for UTUC: a Brazilian cohort study

Abstract Purpose To evaluate the risk factors associated with mortality and recurrence following nephroureterectomy for upper tract urothelial carcinoma (UTUC) in a large Brazilian cohort. Methods This retrospective study analyzed 126 patients who underwent nephroureterectomy for...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Low-Intensity Distortion Product Otoacoustic Emission Protocols in Infants and Young Children: Contributions of Age-Specific Ear Characteristics

Purpose: Despite almost complete cochlear maturity at birth, distortion product otoacoustic emission (DPOAE) levels in neonates and infants are typically higher than those measured in older children and adults, depending on the type and frequency stimulus, which suggests function...

P1.002. Twenty Years Follow-Up in Barrett's Esophagus: Does Fundoplication Demonstrate Superiority in the Comprehensive Long-Term Control of the Disease?

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background The study analyzed the long-term evolution of Barrett's Esophagus (BE) and the effectiveness of clinical and surgical treatments for Gastroesophageal Reflux Diseas...

Frequency and Association between Adverse Childhood Experiences and Psychiatric Outcomes Among Treatment-seeking Patients with Severe Obesity: a Retrospective Observational Study

Abstract Introduction Adverse childhood experiences (ACEs) are well-established risk factors for obesity and psychiatric disorders in adulthood. Despite growing evidence, the association of specific ACE categories with the mental health of patients with severe obesity remains poo...

Percussion, diuresis, and inversion therapy can facilitate lower renal pole stone passage after extracorporeal shock wave lithotripsy and retrograde intrarenal surgery? A systematic review and meta-analysis of randomized controlled trials

Abstract Purpose Patients with lower pole stones (LPS) present a significant challenge for urologists because of the increased likelihood of residual fragments and recurrence following extracorporeal shockwave lithotripsy (ESWL) and retrograde intrarenal surgery (RIRS). Although...

Associação entre o padrão alimentar e o grau de hiperfagia em crianças e adolescentes com a Síndrome de Prader-Willi (SPW).

Introdução: A Síndrome de Prader-Willi (SPW) é uma doença genética rara causada pela ausência de expressão dos genes paternos localizados na região 15q11-q13 do cromossomo 15. Caracteriza-se por hipotonia neonatal, atraso no desenvolvimento neuropsicomotor, alterações hormonais,...

Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis

The effects of gliflozins on bones of CKD patients on dialysis are unknown. Recently, SGLT2 expression in bone tissue of patients with CKD has been reported. We hypothesized that dapagliflozin may act in bone cells and modulate the Klotho-FGF23 axis. This study analyzed the effec...

A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity

Importance: Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective: To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a mi...

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

BACKGROUND: There is a lack of treatments for non-motor symptoms (NMS) in Parkinson's disease (PD). OBJECTIVE: To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. METHODS: This phase II, randomized, placebo-controlled trial ev...

Early‐Stage Esophago‐Mediastinal Fistula After Atrial Fibrillation Radiofrequency Ablation Successfully Treated With Endoscopic Vacuum Therapy

ABSTRACT Background Esophageal injury is a rare but potentially fatal complication of atrial fibrillation ablation, predominantly associated with thermal energy sources. Case Summary A 37‐year‐old man developed an esophago‐mediastinal fistula after radiofrequency ablation for atr...

Educational Value of a Leadership-Focused High-Fidelity Simulation Scenario in Undergraduate Nursing Education: A Single-Group Educational Intervention Study

Aim/Objective: To evaluate undergraduate nursing students’ perceptions of the educational design, debriefing quality, satisfaction, and self-confidence associated with a leadership-focused high-fidelity simulation scenario involving the management of a sharps-injury event. Backgr...

Outcomes of early treatment in acute Vogt-Koyanagi-Harada disease: a 24-month retrospective analysis

Abstract Background To evaluate structural and functional outcomes in patients with acute Vogt-Koyanagi-Harada (VKH) disease, based on the timing of systemic corticosteroid (CS) initiation and the early introduction of noncorticosteroid immunomodulatory therapy (IMT). Methods Thi...

Profile of Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma at a Brazilian High-Complexity Referral Center: Tumor Biology as a Predictor of Post-Transplant Recurrence

INTRODUCTION: Liver transplantation (LT) is considered the optimal curative therapeutic option for most patients with hepatocellular carcinoma (HCC), with 5-year survival rates exceeding 70%. The objective of this study was to analyze the clinical profile of patients undergoing L...