Hospices Civils de Lyon

A theory-informed mixed-methods approach for early implementation assessment in clinical trials of complex interventions

Background Clinical trials of complex interventions often face challenges when translating interventions developed under research conditions into routine practice. Implementation science offers approaches to examine this research-to-practice gap, but strategies for assessing earl...

Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France

“Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus...

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

The projective-attributional trap: institutional dynamics in French assisted reproduction pathways after the 2021 bioethics law

This theoretico-clinical article examines tensions in French assisted reproduction services after the 2021 bioethics law extended access to couples of women and single women. Drawing on composite clinical material from a reproductive medicine service, we define the projective-att...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Sensitive reverse transcription-digital droplet PCR-based discrimination of hepatitis delta virus RNAs reveals differential effects of interferon-α on viral RNA species

Hepatitis delta virus (HDV) replication relies on the production of distinct viral RNA species, including genomic (HDV-G), antigenomic (HDV-AG) and mRNAs (HDV mRNAs), which differ in abundance and function. However, the lack of sensitive and quantitative approaches allowing their...

Assessment of infection prevention practices in office-based surgery: a multicentre regional audit

Abstract Background Office-based surgery (OBS) is increasingly used due to organizational constraints and perceived benefits. However, data on infection prevention and control (IPC) practices in OBS settings remain limited. This study aimed to assess the conditions in which OBS a...

Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series

ABSTRACT Aims Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma‐related obesity. Material and Methods This multicentre retros...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

SENIOR ‐ IPI : An easily applicable prognostic index for first‐line large B‐cell lymphomas patients >80 years treated with curative intent

Summary Using LYmphoma Study Association clinical trials combining 438 first‐line large B‐cell lymphomas (LBCL) patients >80 years old, we defined SENIOR‐IPI, an easily applicable prognostic index for this elderly population treated with an anti‐CD20‐miniCHOP (cyclophosphamide, d...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Extended Data for "A theory-informed mixed-methods approach for early implementation assessment in complex intervention trials: a methodological development study".

Methodological materials accompanying the manuscript “A theory-informed mixed-methods approach for early implementation assessment in complex intervention trials: a methodological development study”. The record contains the materials developed for the identification, classificati...

Involving Patients in Pharmacoepidemiology Studies Conducted on Healthcare Administrative Database: Results of a Feasibility Study in France

BACKGROUND: Patient and public involvement in pharmacoepidemiology using healthcare administrative databases remains limited despite its potential to enhance research relevance and societal impact. We evaluated the feasibility and benefits of involving patients as research partne...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

SLC7A6OS Founder Mutation: A Rare Cause of Progressive Myoclonus Epilepsy Dated to 1100 Years Ago

BACKGROUND: SLC7A6OS c.191A>G is a rare, autosomal recessive cause of progressive myoclonus epilepsy (PME). The c.191A>G variant, first discovered in two families from Türkiye and Portugal, was recently identified in three additional probands from the USA, all of Puerto Rican anc...

ROBOTIC-ASSISTED TOTAL KNEE ARTHROPLASTY USING A SUBVASTUS APPROACH REDUCES BLOOD LOSS AND EARLY REOPERATIONS: A PROPENSITY-MATCHED COMPARATIVE STUDY OF 1,023 CONSECUTIVE TOTAL KNEE ARTHROPLASTIES

Introduction The subvastus approach in total knee arthroplasty (TKA) is a muscle-sparing technique that preserves the extensor mechanism and may facilitate early postoperative recovery. However, limited exposure may complicate implant positioning. Image-based robotic assistance h...

Anesthesia TeleConsultation for Pediatric preoperative assessment: a large national prospective multicentric study in children (TeleCCCAP)

Background: While interest in pediatric anesthesia teleconsultation is growing, published data remain scarce. This study evaluated the feasibility of anesthesia teleconsultation in children, providing a comprehensive analysis of failure, quality, dedicated time and satisfaction....

Patients’ and oncologists’ perspectives on shared decision-making and treatment communication in HR+/HER2 − advanced breast cancer: a multicountry survey

Hormone receptor–positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) breast cancer (BC) represents approximately 70% of all cases. In locally advanced or metastatic stages (laBC/mBC), patients’ quality of life (QoL) often worsens, making shared decision-maki...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...