Hôpital Bretonneau

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

A CCNA1 Missense Variant Associated With Chromatid Non‐Disjunction in Abnormal‐Headed Sperm and Male Infertility

BACKGROUND: Macrozoospermia is a rare form of teratozoospermia characterized by tetraploids, large-headed spermatozoa with multiple flagella, usually caused by bi-allelic AURKC mutations. The etiology of atypical phenotypes with a lower proportion of large headed spermatozoa and...

Open Charm Production as a Residual Test of the Chronon Field Φ(x)

This article reformulates the connection between open-charm production and the Chronon Field Φ(x) within the current operational and falsifiability-first framework of the Chronon Field Program. Open-charm production provides a particularly useful testing ground because it separat...

Chronons and Void : Critical Dialogue between the Chronon Field Φ(x) and the Theory of Objectivity

This article develops a critical and non-reductive dialogue between the Chronon Field Φ(x) and the Theory of Objectivity (TO). Its purpose is not to merge the two frameworks, nor to force a superficial compatibility between them, but to compare them at their strongest defensible...

Comparison of Materno-Neonatal Outcomes Between Cook Balloon and Prostaglandin Methods in Labor Induction Among Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Cohort Study from France

Background: To evaluate whether the methods of induction of labor (IOL) used for pregnancies complicated with fetal growth restriction (FGR) have different impacts on materno-fetal outcomes. Methods: This was a single-center, retrospective cohort study conducted over a one-year p...

The Collapse of Time: When Decoherence Meets Chronon

Quantum superposition describes possibilities that coexist until interactions enforce a selection. If observation collapses the wave function, what collapses time itself ? We explore the hypothesis that temporal flow is coherence-dependent: it emerges and erodes with the stabilit...

The Collapse of Time: When Decoherence Meets Chronon

Quantum superposition describes possibilities that coexist until interactions enforce a selection. If observation collapses the wave function, what collapses time itself ? We explore the hypothesis that temporal flow is coherence-dependent: it emerges and erodes with the stabilit...