Hong Kong University of Science and Technology

Benchmarking copy number alteration inference methods for spatial transcriptomics

Copy number alterations (CNAs), gains or losses of genomic regions, contribute to malignant progression and tumor heterogeneity. Advances in spatial transcriptomics have expanded opportunities to study clonal structure in situ, but direct spatial genomic profiling remains difficu...

Safety Paradox: How Uncertainty Shapes Immersive Engagement and Social Bonding in Location-Based Virtual Reality

Location-based virtual reality (VR) enables large-area movement and co-located interaction in immersive shared environments. However, little is known about how users experience and regulate safety in hybrid physical–virtual spaces, particularly under uncertainty and social coordi...

Does the increase in the minimum wage standard affect corporate innovation? Empirical evidence from Chinese A-share listed companies

Based on the data of Chinese A-share listed companies from 2000 to 2017, a system dynamic panel model is adopted to examine the impact and action mechanisms of the minimum wage standard on the “quantity” and “quality” of corporate innovation in China. Our study finds that: (1) th...

Strong tropical cyclones have a more gradual increase trend through interaction with ocean subsurface

Understanding changes in global tropical cyclone (TC) intensity and their long-term trends is critical for enhancing societal resilience. Given their disproportionate impacts, shifts in strong TCs, which are defined here as Category 4 and above, are of particular concern. We exam...

Honesty in Causal Forests: When It Helps and When It Hurts

Causal forests estimate how treatment effects vary across individuals, guiding personalized interventions in areas like marketing, operations, and public policy. A standard practice is honest estimation—dividing the data into two samples, one to define subgroups and another to es...

Superstitious CEO and Corporate Misconduct: Evidence From China

Using a Chinese dataset that spans from 2007 through 2019, we examine how superstitious beliefs shape managerial behavior, as reflected in corporate misconduct. In traditional Chinese culture, a person’s zodiac year, which recurs every 12 years, is widely believed to bring bad lu...

Distinct constraints but shared dynamics shape the macroevolution of volatile organic compound chemodiversity

Complex metabolic systems have evolved across the tree of life, producing remarkable chemodiversity, yet the structure and evolutionary modes underlying this diversity remain poorly understood. Here, we investigate the macroevolution of chemodiversity using a comprehensive datase...

Fairness‐aware insurance pricing: A multi‐objective optimization approach

Abstract Machine‐learning models can provide accurate predictions in insurance pricing, but can also increase disparities between protected groups. Existing fairness‐aware pricing approaches typically target one fairness notion at a time, making it difficult to compare trade‐offs...

Far From Home? Accessing Everyday Places in Rural and Urban Communities

OBJECTIVES: Rural residents are believed to experience greater social isolation than their urban counterparts. This isolation is typically attributed to the structural conditions that distinguish rural communities from urban communities. In the present study, we direct attention...

A Taxonomy and Systematic Review of Driving Automation Failure Scenarios

Before human drivers are fully removed from the vehicle control loop, transitioning control between automation and human drivers in safety-critical scenarios remains a major challenge. Although existing research has proposed several taxonomies to categorize safety-critical scenar...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

ABSTRACT Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism regulating polarized cellular and tissue behaviors in diverse morphogenetic and physiological processes. Disruption or aberrant activation of PCP signaling can cause developmental defects or pr...

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

ABSTRACT Excellent electromechanical properties of piezoceramic thin films facilitate ultrasonic energy harvesting in bioelectronic systems. However, most piezoceramic thin films are fragile and cannot maintain mechanical integrity under deformation, hindering their application i...

Multimodal fusion of complementary material representations for generalizable and interpretable property prediction

Material properties often depend on coupled compositional, structural, and geometric factors that are incompletely captured by any single representation. We introduce interpretable multimodal fusion (IM-Fuse), a framework that integrates compositional descriptors, crystal graphs,...

Ionic gel-mediated synthesis of nanostructured chiral 2D halide perovskites with amplified chiroptical response

Abstract Chiroptical properties in metal halide perovskites typically arise from asymmetric crystal structures induced by chiral organic molecules during synthesis or chiral additives. However, the synthesis of two-dimensional chiral halide perovskites with sufficiently high diss...

Can Information Design Resolve Electric Vehicle Charging Chaos?

Charging remains an obstacle to the mass adoption of electric vehicles (EVs), especially for long-distance travel. If many EV drivers take to the road around the same time, their "range anxiety" may create a self-fulfilling prophecy. As drivers anticipate uncertainty and congesti...

Two Modes of Self‐Organizing Development of Extreme Rainfall‐Producing Storms in South China

Abstract The convective‐scale dynamics of extreme rainstorms on monsoon coasts (South China) remain poorly understood. This study uses the advanced coupled model WRF‐Chem‐MOSAIC for a 90‐hr, 3‐km simulation, reasonably capturing the thermodynamic conditions, inhomogeneous near‐su...

scProtoTransformer: Scalable reference mapping across molecules, cells, and donors

Abstract The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current research. He...

Tunnel field-effect transistors exhibiting performance beyond the Boltzmann thermionic limit

The International Roadmap for Devices and Systems (IRDS) has identified the tunnel field-effect transistor (TFET) as the most promising next-generation logic device that enables sustainable downscaling in driving voltage and power consumption. Demonstrating an acceptable sub–Bolt...

Hotspot to Homogeneous: Amorphous Interfacial Current Redistribution Enables Stable Solid-State Lithium-Metal Batteries

Abstract Interfacial instability in oxide ceramic electrolyte (OCE)-based solid-state lithium metal batteries (SSLMBs) is conventionally attributed to chemical incompatibility or mechanical failure, yet the underlying atomic-scale mechanisms remain elusive. Here, we reveal that g...