Hong Kong Polytechnic University

A CCCTC-binding factor (CTCF)-fatty acid desaturase 1 (FADS1) axis regulates oncogenic energy metabolism in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein crucial for 3D genome organization and gene regulation. Previous studies have shown that CTCF overexpression in hepatocellular carcinoma (HCC) is associated with poor prognosis. This study aimed to elucidate th...

Aromatic Heterocycle Ligands for Perovskite Photovoltaics: Balancing Defect Passivation and Heterostructure Formation

ABSTRACT Inverted perovskite solar cells (PSCs) possess great potential for improving efficiency and operating stability, but parasitic charge recombination at the interfaces still limits their performance. As additives and surface treatment agents, ammonium ligands have been rep...

Theoretical Study of Emotional Engagement and Artificial Intelligence in Animation

The rapid development of artificial intelligence (AI) has significantly transformed animation tools and techniques in recent years. The film industry has been quick to integrate the new technology into production methods, which affect creative professionals and their artistic out...

AI as a catalyst for innovative scientific research in urban design: enhancing analytical rigour and human centred design

This paper examines Artificial Intelligence (AI) in urban design research as both an analytical tool and an adaptive evaluation framework. By comparing AI-based and traditional methods, it shows how AI can reveal hidden patterns in complex urban systems while supporting human-cen...

Validity of the twin-force analogy in Couette flows

This study combines linear stability analysis (LSA) and direct numerical simulations (DNS) to investigate the coupling mechanisms of rotation, stratification and shear in two flow geometries: spanwise rotating stratified plane Couette flow (between two infinite parallel plates) a...

Whole genome sequencing of multidrug-resistant clinical Klebsiella Isolates from community acquired pneumonia patients at Adama Hospital Medical College, Ethiopia

Klebsiella pneumoniae is a leading Gram-negative pathogen causing severe community-acquired pneumonia (CAP), classically characterized by rapid lung necrosis, cavitary lesions, and production of thick, blood-tinged sputum. CAP is an acute lung infection that develops in a person...

Characterizing the Interaction Mechanism between Asphalt and Mineral Filler in Asphalt Mastics of Mastic Asphalt Concrete Using Rheological Analysis, Hirsch Model, and 3D DEM

Abstract Asphalt binder and mineral filler are key components that significantly affect the properties of mastic asphalt (MA) mixtures. Asphalt mastic, formed by mixing mineral filler and asphalt binder, offers an effective way to study their roles within the MA system. This stud...

Perceiving Asian-ness in Hospitality: Observations From Online Reviews

The arrival of the Asian wave has accelerated the formation and awareness of the Asian paradigm in hospitality and tourism. On the basis of TripAdvisor online reviews, this study explored tangible and intangible services affecting customers’ experiences and perceptions in upscale...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Digital Twin-Enabled Intelligent Stability Management in Ultra-Precision Machining

Abstract Ultra‑precision machining (UPM) is essential for producing components with sub‑micron accuracy and superior surface finish, yet its industrial adoption is constrained by low efficiency, complex stability management, and insufficient intelligent monitoring. To address the...

Uridine mitigated Listeria monocytogenes infection in mice by improving gut microbiota and protecting the intestinal barrier

Abstract This study investigated the protective effects of uridine against Listeria monocytogenes infection in mice and explored the underlying mechanisms. Uridine markedly suppressed pathogen loads in the liver and spleen, mitigating infection-induced pathological damage. In ter...

How testosterone administration affects social rank perceptions: A double-blind, placebo-controlled study

Navigating social hierarchies is fundamental to human survival and reproductive success, relying heavily on the accurate perception of social rank. However, the neuroendocrine mechanisms underlying this perception remain largely uncharted. Given testosterone’s established role in...

Adherence to the Mediterranean dietary pattern and mental health outcomes in Hong Kong adults: a cross-sectional study

Abstract Background Adherence to the Mediterranean dietary pattern (MDP) has been associated with lower depressive, anxiety, and insomnia symptoms, yet associations with stress, health-related quality of life (HRQoL), and functional impairment, as well as those of individual MDP...

Material Controls on Landslide-Dam Breach Evolution and Hydrograph Response: A Review

Landslide-dam breaching can generate short-lived, high-magnitude outburst floods, but breach hydrograph prediction remains limited by uncertainty in dam material properties. This review synthesises experimental, field, and modelling evidence through a process chain-linking grain-...

Assessment of the plane of maximum curvature in adolescent idiopathic scoliosis using 3D ultrasound

Aims The size of the curves in patients with adolescent idiopathic scoliosis (AIS) is traditionally assessed using 2D Cobb angles, which may underestimate the extent of this complex 3D deformity. The plane of maximum curvature, measured using 3D reconstructions of the spine, incl...

Dual-Task Exercises for Dynamic Balance, Motor Function, Functional Mobility, and Dual-Tasking in Individuals With Parkinson’s Disease: A Meta-Analysis With Meta-Regression

To evaluate the (1) effectiveness of dual-task (DT) exercise in improving dynamic balance, motor function, functional mobility, dual-tasking, and falls, and (2) influence of DT intervention parameters on treatment effects in individuals with Parkinson’s disease (PD). A comprehens...

Measurement report: Quantifying the trade-off between station number and spatial layout in sparse GNSS networks for calibrating all-weather FY-4A precipitable water vapor

Abstract. Integrating satellite-derived precipitable water vapor (PWV) provides data with high spatiotemporal resolution, which is crucial for monitoring and forecasting extreme weather. However, current fusion and calibration methods typically relies on dense GNSS networks, hind...

An interpretable learning framework for exploring superelastic degradation of NiTi shape memory alloys using multimodal data

Abstract Superelastic degradation (SED), a progressive loss of functionality in NiTi shape memory alloys under cyclic loading, remains challenging to characterize precisely, thereby constraining their engineering applications and broader adoption. In this study, an interpretable...

MDFNet: a lightweight multi-stream network tailored for real-time GIS and disaster monitoring applications

Very high-resolution remote sensing image scene classification (RSSC) is a key enabling technology for geographic information systems (GIS) in disaster prevention, emergency response, and recovery. Current methods often suffer from excessive complexity, restricting their capabili...

Integrated Optimization of Multi-period Yard Template Planning and Loading and Unloading Scheduling for Transshipment Vessels

This paper addresses an integrated multi-period optimization problem that coordinates yard template planning and loading/unloading scheduling for transshipment vessels with heterogeneous visiting cycles. The objective is to minimize container transportation and vessel service cos...