Hokkaido University of Science

Dehnel's phenomenon is not a simple reduction of size: seasonal change in skull shape of the long-clawed shrew (Soricidae, Mammalia)

Abstract Dehnel's phenomenon—a reversible seasonal reduction and regrowth of body size, skull, brain and visceral organs—is an extreme adaptive strategy, enabling small mammals to survive winter energetic constraints. First described in the common shrew Sorex araneus, similar sea...

Supramolecular Polymerization and Morphological Transformation of Dynamic Helical Poly(Phenylacetylene)s via Chain‐End Host–Guest Interactions

ABSTRACT Integration of dynamic helical polymers with supramolecular polymerization offers a promising strategy for constructing adaptive hierarchical chiral materials. However, the transformation of molecular‐level conformational changes in dynamic helical polymers into structur...

Development of a Conformational Sampling Method for Transition State Structures With Diverse Active Bond Lengths

We describe TStrail, a transition state (TS) conformational sampling tool that automatically generates TS conformers without fixing the bond forming/breaking distance of an initial TS structure. Conventionally, the conformations of TS structures were searched with the fixed lengt...

Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131

Background Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence linking resistance determinants to pathog...