Hippocration General Hospital

High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention: How to Choose the Optimal Antithrombotic Therapy, Its Duration and the Right Stent; A Comprehensive Review of the Current Literature and Proposed Treatment Algorithms

High bleeding risk (HBR) patients represent a significant proportion of those who undergo percutaneous coronary interventions (PCI). The accurate diagnosis of the HBR population is essential because they suffer significantly higher rates of mortality and bleeding compared with no...

Candidozyma auris Prosthetic Joint Infection: A Case Report and Systematic Case-Based Literature Review of Osteoarticular Infections

Candidozyma auris, recently taxonomically reclassified, represents an emerging multidrug-resistant fungal pathogen that has evolved into a critical nosocomial and global public health threat. This organism exhibits a profound capacity for resilient biofilm formation on biotic and...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

Integrated Molecular, Clinicopathological and Immune Profiling of Non-Small Cell Lung Cancer: The MONREPOS Hellenic Cooperative Oncology Group (HeCOG) Study (HE_2TR/13)

Integrated assessment of tumour genomics and immune biomarkers may improve prognostic stratification in non-small cell lung cancer (NSCLC). We examined the distribution and prognostic relevance of somatic pathogenic/likely pathogenic variants (PVs), somatic copy-number alteration...

Infections and Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents: A Scoping Review of Evidence Since the COVID-19 Pandemic

Background/Objectives: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common autoimmune encephalitis affecting children and adolescents. Its development has been associated with preceding or concomitant infections, particularly herpes simplex virus type 1 (HSV-...

Effectiveness of early initiation of idursulfase in infants and very young children with mucopolysaccharidosis II: a retrospective chart review in siblings

Introduction Enzyme replacement therapy (ERT) with intravenous idursulfase is the standard of care for patients with mucopolysaccharidosis II (MPS II; Hunter syndrome). Data are limited for children aged ≤12 months. This retrospective study evaluated outcomes with early ERT. Meth...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates

Background/Objectives: We assessed changes in nonfatal disease burden and risk attribution in Romania between 1990 and 2023. Methods: We analysed Global Burden of Disease (GBD) 2023 estimates of years lived with disability (YLDs), related nonfatal measures and risk attribution fo...

Prediction of atrial fibrillation recurrence before catheter ablation using P-wave ECG features: simplicity of random forest versus CNN in small datasets

Atrial fibrillation (AF) is an arrhythmia affecting 3% of the general population. Transcatheter ablation (CA) is the most effective treatment option for patients with AF; however, recurrence rates remain high. Early classification of patients based on pre-ablation data could help...

Cause of death in a contemporary cohort of patients with pulmonary arterial hypertension

Abstract Background In pulmonary arterial hypertension (PAH), contemporary risk tools primarily estimate all-cause mortality, offering limited insight into what patients die from. Aims We aimed to characterize causes of death across baseline risk strata and to examine baseline fa...

Associations between physical activity levels and self-perceived quality of life and well-being in hemodialysis patients and their informal caregivers: a multicenter cross-sectional study

BACKGROUND: This study aimed to investigate the associations between the physical activity of hemodialysis (HD) patients and their informal caregivers and measures of their well-being and quality of life (QoL). METHODS: This multi-center cross-sectional study included one hundred...

Contribution to Diagnostic Accuracy and Prognostic Significance of MicroRNAs in Thyroid Cancer

The incidence of thyroid cancer, the most common endocrine malignancy, has increased significantly, underscoring the need for improved diagnostic and prognostic methods. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression and play vital roles in ca...

Prevalence of Persistent Left Superior Vena Cava in Patients with Congenital Heart Disease: A Systematic Review with Meta-Analysis

Persistent left superior vena cava (PLSVC) is the most frequently reported anatomical variant of the thoracic systemic venous system. While its association with congenital heart disease (CHD) is well recognized, its prevalence within CHD populations and its relative occurrence co...

Interleukins and Cardiovascular Disease

Interleukins are important inflammatory cytokines involved in cardiovascular (CV) disease (CVD) pathogenesis, particularly in atherosclerosis, by regulating inflammation, endothelial dysfunction, plaque formation, thrombosis, immune responses, and hematopoiesis. High levels of in...