Herlev Hospital

Development and Validation of a Blood Test Informed Risk Prediction Model for Lung Cancer—The Copenhagen Lung Cancer Risk Model (CPH-Lung)

Purpose Lung cancer screening reduces lung cancer mortality, but identifying high-risk individuals remains difficult. We wanted to develop a blood test–based risk model (CPH-Lung) to improve risk stratification before image-based screening. Materials and Methods We included indiv...

Higher plasma vitamin D levels are not causally associated with less age‐related macular degeneration

PURPOSE: Higher levels of plasma 25-hydroxyvitamin D have been associated with a lower risk of age-related macular degeneration (AMD). We investigated observational and potential causal associations of plasma 25-hydroxyvitamin D with the risk of AMD in two large contemporary popu...

Risk of malignant melanoma in hyperthyroid and hypothyroid female populations: Results from a large Danish cohort study

Introduction Experimental studies suggest that thyroid hormones may influence tumor development through endocrine and cellular signaling pathways. Although malignant melanoma (MM) is primarily associated with ultraviolet radiation exposure, the potential role of thyroid dysfuncti...

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

Gold Contact Sensitization, Clinical Characteristics and Associations With Autoimmune Disease: A Retrospective Cohort Study With Registry Linkage

ABSTRACT Background Gold sensitization is common, but its clinical and immunologic significance remains unclear. European data from consecutively patch tested patients are scarce. Animal models suggest that gold can induce systemic autoimmunity, but studies in humans are limited....

Early antimicrobial therapy and clinical outcomes of left-sided Enterococcus faecalis endocarditis: a NIDUS registry study

Abstract Purpose Antimicrobial therapy of Enterococcus faecalis endocarditis treatment is challenged by high intrinsic resistance and relapse rates. Knowledge on practice patterns is warranted. We aimed to describe early-phase monotherapy and combination therapy use in E. faecali...

Sexual and relational challenges in men and women affected by prostate cancer: a Project SEXUS study

OBJECTIVES: To examine, in a nationally representative Danish study, a comprehensive range of sexual characteristics, dysfunctions and relational challenges among men with prostate cancer (PCa) aged ≥50 years and women married to such men, compared with unaffected men and women....

Bone Anabolic Treatment in Patients With Chronic Kidney Disease: A Systematic Review

BACKGROUND: Chronic kidney disease (CKD) associated osteoporosis leads to an increased risk of bone fracture in patients with CKD. Evidence on the efficacy and safety of anti-osteoporotic medications is limited for this group. This systematic review aimed to examine the efficacy...

Exploring the Feasibility and Acceptability of Compassion and Mindfulness Training for Adolescents With Type 1 Diabetes and Their Caregivers

AIM: To examine the feasibility and acceptability of mindfulness training for adolescents with Type 1 diabetes (T1D) and compassion training for caregivers. METHODS: Adolescents aged 12-17 years with T1D, and their caregivers were recruited from two diabetes centres between 2022...

Variation in assessment of dissection plane after transanal total mesorectal excision (TaTME) among experienced colorectal pathologists

Abstract Purpose Evaluation of the dissection plane is an important measure of surgical quality in relation to rectal cancer. Although well-defined criteria exist assessments may vary. The aim of this study was to assess variation in the evaluation of dissection plane of transana...

Paired comparisons and regression to the mean – with emphasis on graphical illustrations

To review methods for graphical illustration of paired comparisons in the pretest-posttest design and present a new and simple plot, based on the waterfall plot combined with evaluation of vertical symmetry. The plot includes changes in the raw data, median changes with confidenc...

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

BACKGROUND: Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological...

Distinct body mass index trajectories throughout childhood in girls with early puberty

Abstract Background Early pubertal development in girls has been associated with increased adiposity in childhood. However, longitudinal body mass index (BMI) trajectories preceding the diagnosis of precocious puberty (PP) or premature adrenarche (PA) are less well described. We...

Immune regulation includes an effector arm: therapeutic implications of phase III IDO/PD-L1 vaccination in melanoma

In a recent phase III study in Annals of Oncology , first-line IDO/PD-L1 peptide vaccination plus pembrolizumab in advanced melanoma provided clinical support for a microenvironment-targeting vaccine strategy. The broader significance of these data is that they support immune mod...

Impaired Lung Function in Liver Transplant Recipients Compared With the General Population: A Nationwide Matched Cohort Study

Background. Liver transplant recipients have elevated risk of acute pulmonary infections, but the burden of chronic pulmonary diseases in liver transplant recipients remains largely unknown. We aimed to determine the association between living with a transplanted liver and both s...

Risk of bone metastases on [18F]NaF PET/CT in 734 patients with newly diagnosed prostate cancer

Abstract Purpose International guidelines recommend assessment for bone metastases in patients with high-risk prostate cancer (PC) and those with unfavourable intermediate-risk disease. These recommendations are largely based on studies using planar bone scintigraphy. We aimed to...

Elevated remnant cholesterol is estimated to mediate part of excess cardiovascular risk in the metabolic syndrome: two cohort studies of 537,885 individuals

Abstract Background Individuals with the metabolic syndrome have elevated remnant cholesterol and increased cardiovascular risk. We tested the hypothesis that elevated remnant cholesterol mediates part of the excess risk of myocardial infarction, atherosclerotic cardiovascular di...

Perioperative Use of Vasoactive Agents in Patients Undergoing Gastrointestinal Surgery: A Protocol for a Scoping Review

BACKGROUND: Perioperative hypotension in patients undergoing gastrointestinal surgery is a known and well-described condition. Timely treatment of perioperative hypotension, regardless of the reason, is important in order to reduce the associated postoperative complications. The...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Effect of thermal ablation on persistent HPV infection in Danish women ≥ 40 years of age: a quasi-randomized clinical study

Thermal ablation is a cervical heat treatment that destroys a defined area of the cervix. We evaluated whether thermal ablation facilitates HPV clearance in women with persistent high-risk human papillomavirus (HR-HPV) infection, using HPV status and FAM19A4/miR124-2 DNA methylat...