Henan Provincial People's Hospital

Exploration and evaluation of “1 + N” paired teaching mode for resident physicians and medical interns

To explore and evaluate the mode of “1 + N” paired teaching for resident physicians and medical interns, in order to optimize the effect of both resident training and internship. A total of 72 residents and 162 interns rotating in the same period in the department of Gastroentero...

¹⁸F-FDG PET/CT models with and without delayed-phase imaging for indeterminate pulmonary nodules: development and temporal validation

The incremental diagnostic value of delayed-phase ¹⁸F-FDG PET/CT for indeterminate pulmonary nodules remains uncertain. We compared conventional and extended models incorporating delayed metabolic retention. This single-center retrospective study included 612 patients with one in...

Association of dietary antioxidant patterns with heart failure risk in patients with hypertension

Hypertension is a major modifiable risk factor for heart failure (HF) and contributes substantially to the cardiovascular disease burden in China. Oxidative stress and redox imbalance have been implicated in the progression from hypertension to HF. The composite dietary antioxida...

Exploring the relationship between gut microbiota and pan-cancer: a meta-analysis of Mendelian randomization studies

The relationship between the gut microbiota and cancer is of increasing interest, but remains incompletely understood. This study synthesized evidence from Mendelian randomization (MR) studies to assess the association between genetically predicted gut microbiota abundance and pa...

Association between cerebral autoregulation and optimal cerebral perfusion pressure after hypertensive intracerebral hemorrhage under neuromultimodal monitoring

Objective Standardized blood pressure thresholds cannot address individualized cerebral perfusion needs in hypertensive intracerebral hemorrhage (HICH). The role of optimal cerebral perfusion pressure (CPPopt) and its association with multimodal cerebral indices in HICH remain po...

The gut-ovary axis: how microbial players orchestrate female reproductive health

Ovarian dysfunction—encompassing polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), and ovarian aging—poses a significant challenge in reproductive medicine, largely due to the limited availability of etiology-based treatments. Emerging evidence positions th...

A prognostic model for pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome based on sarcopenia

Sarcopenia has been shown to be associated with the prognosis of patients with liver cirrhosis, hepatocellular carcinoma, liver failure. However, the impact of sarcopenia on survival has not been investigated in patients with pyrrolizidine alkaloids (PAs)-induced hepatic sinusoid...

From Past Achievements to Future Hotspots: Bibliometric View of Influential Studies on Microfracture Research

ABSTRACT Background Microfracture has historically been considered an acceptable method for treating cartilage defects. A substantial body of literature on this technique has accumulated over the past few decades. Citation metrics serve as a critical tool for assessing scholarly...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Efficacy of low-level laser therapy for subacromial impingement syndrome: a meta-analysis of randomized controlled trials

To systematically explore the therapeutic effects of low-level laser therapy (LLLT) on pain, shoulder range of motion (ROM), and functional disability in patients with subacromial impingement syndrome (SIS). Eight databases were systematically searched. We assessed study quality...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Risk prediction model and intervention strategies for intraoperative hypothermia in robotic-assisted urological surgery

To develop a risk prediction model for intraoperative hypothermia in patients undergoing robotic-assisted urological surgery and formulate hierarchical warming strategies. This single-centre retrospective study calculated the sample size using G*Power 3.1. A total of 487 patients...

Innate immune sensor NOD2 promotes cartilage degradation and osteoarthritis progression by stabilizing TRAF6 in chondrocytes

Inflammation driven by the innate immune response plays a crucial role in osteoarthritis (OA) pathogenesis, yet the underlying mechanisms remain incompletely understood. Moreover, current antiinflammatory therapies primarily offer symptomatic relief without altering disease progr...

Pulmonary embolism in lung cancer: a retrospective exploratory study

Lung cancer is associated with a high risk of venous thromboembolism, and pulmonary embolism (PE) is a critical complication. The synchronous diagnosis of PE at the initial presentation of lung cancer presents diagnostic challenges and affects management. The predictive factors f...

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....