Henan Medical University

DDX3X forms a complex with METTL3 to promote glioma progression via tumor immune microenvironment remodeling

Methyltransferase-like 3 (METTL3) is the key catalytic subunit of the N6-adenosine methyltransferase complex regulating N6-methyladenosine (m6A) modification of mRNA in mammalian cells. Although METTL3 expression is elevated in multiple cancers, the regulatory mechanisms are stil...

Uric acid-to-albumin ratio and all-cause mortality in dilated cardiomyopathy: a cohort-based prognostic analysis

Abstract Background Nutritional and metabolic abnormalities may contribute to adverse outcomes in dilated cardiomyopathy (DCM). The uric acid-to-albumin ratio (UAR), derived from two routinely measured biochemical parameters, may reflect this broader systemic burden. This study e...

Constrained endurance in long-term family caregiving: Rethinking resilience through nursing ethics

Resilience is an established concept in family-caregiver research, where it is used to describe how caregivers maintain functioning and adapt to sustained adversity. In long-term family care for older adults with disabilities, however, resilience is ethically ambiguous. Continued...

Switchable Electroosmotic Delivery via Capillary Shrunken Reduced Graphene Oxide Membrane

Abstract A capillary-force-assisted reduced graphene oxide (rGO) membrane is developed for electrically controlled electroosmotic flow (EOF). By combining capillary drying with subsequent freeze-drying, structural shrinkage is used to continuously control the pore size and channe...

Augmenting antitumor immunity in colon cancer via GSDMD-mediated pyroptosis induced by an attenuated Salmonella delivery system

As a major gastrointestinal malignancy, colon cancer (CC) demands more effective therapies. Gene therapy is an emerging promising strategy, and pyroptosis, a novel lytic cell death form, serves as a vital antitumor target, with Gasdermin D (GSDMD)—a key pore-forming protein in py...

Pathological changes in ventricular false chordae tendineae in patients with dilated cardiomyopathy.

OBJECTIVE: To investigate the pathological changes in ventricular false chordae tendineae in patients with dilated cardiomyopathy (DCM). METHODS: Gross anatomy, histology, immunohistochemistry, and immunofluorescence techniques were employed to examine the anatomical features, ti...

Association between cerebral autoregulation and optimal cerebral perfusion pressure after hypertensive intracerebral hemorrhage under neuromultimodal monitoring

Objective Standardized blood pressure thresholds cannot address individualized cerebral perfusion needs in hypertensive intracerebral hemorrhage (HICH). The role of optimal cerebral perfusion pressure (CPPopt) and its association with multimodal cerebral indices in HICH remain po...

Identification of SST as a glioblastoma diagnostic biomarker via integrated bulk and single-cell transcriptomics and DrugReflector AI-driven drug discovery

This study aims to identify reliable diagnostic biomarkers and explore their biological significance in glioblastoma (GBM). The bulk transcriptomic dataset GSE68848 was used for differential expression and weighted gene co-expression network (WGCNA) analyses, and core genes were...

The AURKA–PTTG1 signaling axis induces enzalutamide resistance in prostate cancer

Background Prostate cancer (PCa), a common male malignant tumor, often develops resistance to the androgen receptor inhibitor enzalutamide (ENZ). Despite its established oncogenic role, pituitary tumor-transforming gene 1 (PTTG1)’s specific function and regulatory mechanism in EN...

Human metapneumovirus in central China, 2024–2025: epidemiology, co-infections, and temporal dynamics

Human metapneumovirus (HMPV) is a major cause of acute respiratory infections in children, but comprehensive data from sentinel surveillance in the post‑pandemic period remain limited. Understanding its epidemiology and co‑infection patterns is critical for surveillance and preve...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

Trends in Smoking-Attributable Disease Burden in China, 1990–2021: Age, Sex, and Risk Factors in a Global Context

INTRODUCTION: Smoking remains one of the leading preventable causes of morbidity and mortality worldwide. Understanding long-term trends in smoking-related diseases is essential for evaluating policy effectiveness and guiding prevention efforts. This study assessed the burden of...

MergeNeXt: a hybrid CNN–transformer model for retinal OCT image classification

Abstract Retinal disease recognition is a critical component of computer-aided diagnosis (CAD). Despite advancements, existing models often struggle to capture both fine-grained local details and complex global relationships in optical coherence tomography (OCT) images. This stud...

Food‐Borne Environmental Contaminants, Intestinal Injury, and Early Childhood Stunting: A Developmental Toxicology Perspective

BACKGROUND: Childhood stunting (height-for-age z-score < -2 SD) remains a global developmental health burden. Traditional interventions centered on nutrition and infection have reached a bottleneck. Emerging evidence identifies chronic low-dose dietary environmental toxins as an...

Network analysis of smartphone addiction, attentional control, and learning adaptation among nursing undergraduates

In the digital learning environment, learning adaptation and attentional control have been shown to be important factors associated with academic success among nursing undergraduates. Smartphone addiction has been associated with impaired attentional control and poorer learning o...

DFT‐assisted rational design of salan ligands for highly enantioselective Zr–salan‐catalyzed hydroxylation of cyclic β ‐keto esters

Abstract In this work, a structurally simple, inexpensive, and readily accessible Zr–salan catalytic system was designed and developed with the aid of density functional theory (DFT) calculations. Density functional theory studies revealed that stereocontrol arises primarily from...

Factors associated with 30-day unplanned readmission after first-ever ischemic stroke: a retrospective cohort study in China

Unplanned readmission is an important post-stroke outcome, but clinically detailed data from Chinese cohorts remain limited. We evaluated the frequency of 30-day unplanned readmission after first-ever ischemic stroke and examined clinical factors associated with this outcome. We...

Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis

Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal disorders that pose significant threats to human health and share common pathological features, including intestinal mucosal barrier disruption and gut microbiota dysbiosis, in which fucosyl...

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

<title>Abstract</title> Abemaciclib is used for the treatment of breast cancer (BC) in clinics. The combination of abemaciclib and imperatorin or isoimperatorin has been studied <italic>in vitro</italic> and <italic>in vivo</italic> to explore the pharmacokinetics of Chinese herb...