Helsinki University Hospital

Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis

Background/Objectives: Bruxism, encompassing both awake (AB) and sleep bruxism (SB), is a prevalent condition associated with involuntary jaw muscle activity, leading to tooth wear and muscle hypertrophy. Botulinum toxin type A (BoNT-A) has emerged as a potential treatment by red...

A genetic and historical perspective on the origins of keratitis fugax hereditaria

Abstract Purpose To investigate the genetic and genealogical background of keratitis fugax hereditaria (KFH), a periodic corneal disease caused by the heterozygous pathogenic variant c.61G>C in the NLRP3 gene. KFH is characterized by recurrent unilateral autoinflammatory attacks...

Alcohol and other drug policies for health care workplaces: evaluation of the content, quality and implementability

Purpose Research on alcohol and other drug policies (AOD policies) at workplaces has been conducted mainly in the manufacturing industry and among general working population. There is a lack of research from health care workplaces. This study describes the content and evaluates t...

Craniofacial growth in Mulibrey nanism and impact of growth hormone treatment

Abstract Background Mulibrey nanism (MUL) impacts cellular metabolism and leads to severe prenatal onset growth restriction, distinctive craniofacial features, heart disease, hypogonadism, and predisposition to tumors. Growth hormone therapy is commonly used in treatment of patie...

Multi-omic profiling reveals antibody-drug conjugate targetability in ovarian cancer

Abstract Antibody-drug conjugates (ADCs) require high and homogeneous target expression for optimal efficacy, yet the spatial, temporal, and cellular heterogeneity of clinically approved ADC targets in high-grade serous ovarian cancer (HGSC) remains incompletely defined. We analy...

Cluster-based identification of movement patterns in bilateral and unilateral drop jump tasks: insights into the performance–injury conflict

Stiff landing mechanics has been associated with increased anterior cruciate ligament (ACL) injury risk, yet it may optimise jump performance, creating a theoretical performance-injury conflict. This study examined movement patterns, their consistency, and performance during two-...

Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways

Abstract Septic shock represents the most severe form of infection-driven systemic inflammation, whereas acute pancreatitis induces a sterile inflammatory response. Although clinically similar, their molecular profiles may reveal distinct mechanisms underlying infectious and non-...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Abstract Background The use of computed tomography at the early stage of acute appendicitis can lead to overdiagnosis and predispose patients unnecessarily to ionising radiation. Adult Appendicitis Score (AAS) can be used to select patients for imaging. Observation and re-scoring...

Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study

Abstract Background Prematurity is associated with a high risk of abnormal neurodevelopment, inflicting life-long neurocognitive consequences with major public health importance. This calls for early biomarkers of functional brain development to serve as indicators of the effect...

Screening ‘Gum Disease or Problem’ Status Using Molar Probing Depths: Model Development and Validation in NHANES Young to Middle-Aged Adults

Background/Objectives: A parsimonious multivariable model was engineered and externally validated using dental electronic health records to screen for a clinician-evaluated “gum disease or related problem” status. Designed for seamless electronic integration, a positive screening...

Interpretable multi-modal hierarchical framework to support cytomorphological analysis of hematologic cancers

Cytomorphological analysis of bone marrow aspirate (BMA) and peripheral blood smears (PBS) remains a diagnostic cornerstone in hematology. Machine-assisted analysis could support diagnostic workflows, but remains challenging due to the imbalanced prevalence of hematologic maligna...

The Björck classification of the open abdomen revisited: clarifying concepts for modern complex abdomen management

Abstract Introduction The open abdomen (OA) has become an integral component of modern acute care, trauma, and vascular surgery. Since 2009, the Björck classification, amended in 2016, has provided a common language for describing the status and progression of the OA and remains...

Preferential Retention of the LMP-1 Promoter at EBV Integration Sites in Lymphomas: Evidence from Cartilage Hair Hypoplasia and Controls

Abstract Purpose Cartilage-Hair Hypoplasia (CHH), a rare ribosomopathy characterized by immune deficiency, carries a markedly increased risk of early-onset malignancy, particularly lymphoma. However, the molecular drivers of malignant transformation in CHH, and the contribution o...

Translation, cultural adaptation and psychometric validation of the Shoulder Pain and Disability Index into Finnish

Shoulder pain is a leading cause of disability, often resulting in functional limitations and reduced quality of life. Valid, culturally adapted patient-reported outcome measures (PROMs) are essential for assessing symptoms and treatment outcomes across populations. The Shoulder...

P1.230. Rare Esophageal Cancers in Finland: A 30-Year Nationwide Registry Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancers other than adenocarcinoma and squamous cell carcinoma are rare and not well characterized. Most evidence published are case reports or small institutional...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Prevalence of Lumbar MRI Changes Associated with Nerve Root Compression Among Middle-aged People - A Northern Finland Birth Cohort 1966 Study

Study design. A cross-sectional study. Objective. To evaluate the prevalence of lumbar MRI changes associated with nerve root compression in a large, unselected middle-aged population. Summary of Background Data. While degenerative spinal changes are frequently observed in imagin...

The liver in diabetes: current state and future perspectives

Abstract Diabetes mellitus is strongly associated with metabolic dysfunction-associated steatotic liver disease (MASLD). For many years, MASLD has not been recognised as either a common pathophysiological feature of type 2 diabetes or a diabetes-related complication. This special...