Helsinki University Hospital

Long-term incidence and predictors of in-stent restenosis after chronic total occlusion percutaneous coronary intervention: a cohort study

Background In-stent restenosis (ISR) remains a major limitation after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). However, long-term patency data after chronic total occlusion (CTO) PCI are limited despite high ISR risk. We evaluated long-term ISR in...

Discovery and Design of YTHDF2-Selective and Pan-YTHDF Inhibitors for m6A Binding by the YTH Aromatic Cage

Abstract Recognition of N6-methyl-adenosine (m6A) in the RNA sequences by the YT521-B homology domain-containing protein family paralogs 1–3 (YTHDF1–3) is a dominant layer of myriad cellular regulation. Dysregulated YTHDF paralog expression and activities have been reported in ca...

Cholangioscopy in the diagnostic and therapeutic work-up of intraductal papillary neoplasms of the bile duct: a systematic review and meta-analysis

Background: Intraductal Papillary Neoplasms of the Bile Duct (IPNB) are rare and diagnostically challenging, particularly in assessing invasiveness and intraductal spread. Cholangioscopy offers promise through direct visualization and targeted biopsies. The aim of this study was...

Outcome of Secondary Glaucoma in Eyes With Uveal Melanoma A Population-Based Analysis

Précis: Over 50% of eyes with uveal melanoma and secondary glaucoma with ≥20/400 vision retain that level through 5 years, and over 90% with <20/400 vision are pain-free. Over 90% avoid secondary enucleation for intractable glaucoma. Purpose: To report outcome of secondary glauco...

Sensitivity to ATR–CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss

Abstract SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensi...

Surgical Indications for Type II Thyroplasty in Adductor Spasmodic Dysphonia: A Scoping Review

ABSTRACT Objective This scoping review mapped evidence on surgical eligibility criteria, efficacy, durability, and safety of Type II thyroplasty with titanium bridges for adductor spasmodic dysphonia to identify gaps and inconsistencies among studies and propose preliminary inter...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

No evidence of increased gaming-related problems with long-term use of a video game therapeutic: Exploratory endpoint findings from a randomized controlled trial

Digital therapeutics for mental health often face low patient engagement, which limits their clinical impact. Interventions that deliver treatment using a video game medium may improve engagement and therapeutic efficacy, but the potential emergence of gaming-related problems rem...

Prehospital whole blood transfusion versus component therapy—A scoping review

Abstract Background Whole blood has gained a foothold over component therapy in civilian emergency care, especially in emergency departments. In a prehospital setting, whole blood might be the logistically easier alternative compared to component therapy. However, most previous s...

The Mobile Hospital delivers outreach acute care to nursing homes: healthcare staff interviews

Abstract Background Nursing home residents often face unnecessary risks when visiting the emergency department (ED). Due to the limited rapid response capabilities of primary care and lack of equipment for acute illnesses, onsite specialized outreach units present a novel alterna...

Age-based prognosis in oral tongue squamous cell carcinoma patients: A systematic review and meta-analysis

Abstract Background The prognostic significance of younger age in oral tongue squamous cell carcinoma (OTSCC) remains uncertain because age definitions, treatment strategies, outcome definitions, and adjustment methods vary substantially across studies. Objective To evaluate the...

Intraoperative monitoring of myocardial oxygenation during open-heart surgery: feasibility and initial performance

Abstract Myocardial protection during cardiopulmonary bypass relies on intermittent administrations of cardioplegia without continuous, tissue‑level feedback on myocardial oxygen supply and mitochondrial metabolic status. Extended near‑infrared spectroscopy (eNIRS) can enable rea...

An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts

Abstract Cancer-associated fibroblasts (CAFs) promote tumorigenesis and represent potential therapeutic targets, highlighting the need for precise understanding of CAF heterogeneity. In colorectal cancer (CRC), CAF subsets and nomenclature vary widely, and many studies overlook t...

Compensated Patient Injury Cases Due to Medication Errors in Finland During 2021 to 2023: A Cross-Sectional Register-Based Study

Objectives: To analyze follow-up data on medication errors (ME) in compensated patient claims in Finland from 2021 to 2023 and to discuss whether medication safety has improved since 2013 to 2014. Methods: This was a cross-sectional retrospective register-based study analyzing th...

Bedside infrared thermometry compared with continuous zero-heat-flux thermometry– an experimental and clinical study

This study compared standard infrared thermometers used in emergency rooms (ER) and wards to a Zero-Heat-Flux (ZHF) thermometry device and evaluated its feasibility for continuous bedside temperature monitoring. In 60 volunteers, five alternative ZHF sensor placements were assess...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the FIELD study

Abstract Aims/hypothesis Metabolic risk in type 2 diabetes is not fully captured by standard clinical measures. Use of NMR-based metabolomic indices may enhance risk prediction, but their role in individuals with type 2 diabetes is unresolved. Methods We analysed data from 9550 a...

LazypipeX: customizable virome analysis pipeline enabling fast and sensitive virus discovery from NGS data

Abstract Metagenomic next-generation sequencing (mNGS) is pivotal for detecting known and novel viruses, however, its efficacy depends on applied bioinformatics pipelines. We present Lazypipe Extended (LazypipeX), an mNGS pipeline employing modular “annotation strategies” to opti...

The effect of hyperoxic environment on lung function and myopisation in an extended closed-circuit rebreather diving expedition

Introduction: Repetitive closed-circuit rebreather (CCR) dives subject the human body to a hyperoxic environment. Prolonged oxygen exposure can lead to lung abnormalities and myopic shift. The aim of this study was to analyse the effects of a 31-day period of repeated CCR dives o...