Helmholtz-Zentrum Dresden-Rossendorf

A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions

Abstract Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture sy...

Superconductivity in epitaxial PtSb(0001) thin films

Building on earlier reports of superconductivity in bulk PtSb, we present a systematic study of superconductivity in epitaxial PtSb(0001) thin films grown on SrF 2 ( 111 ) . Electrical transport measurements reveal a superconducting transition at T c = 1.72 K . The field-induced...

Beyond in silico prediction: multi-omics to identify a pathogenic deep intronic HNRNPK variant in Au-Kline syndrome

Abstract Pathogenic variants in HNRNPK are associated with autosomal dominant Au-Kline syndrome (AKS, Au-Kline-Okamoto syndrome, OMIM #616580). This syndrome is characterized by developmental delay and intellectual disability, hypotonia, and distinctive facial features. Despite t...

Model-free interpretation of X-ray Thomson scattering measurements

Abstract X-ray Thomson scattering (XRTS) has emerged as a widely used diagnostics for extreme states of matter in a great variety of situations, and over a broad range of parameters. The standard approach for the interpretation of XRTS measurements is given by the forward modelin...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

3D bulk-resolved g-wave altermagnetic order parameter in CrSb

Abstract Electronic phases of matter, such as magnetism and superconductivity, are defined and distinguished by their order parameters quantifying the spontaneous symmetry breaking underlying each phase. Simple cases include the uniform magnetization of ferromagnets 1,2 and the i...

Atomic‐Scale Detection of Néel Vector Switching in the Single‐Layer A‐Type Antiferromagnet Cr 2 S 3 ‐2D

ABSTRACT The detection of Néel vector switching in a single‐layer A‐type antiferromagnet marks an important step toward functional two‐dimensional spintronics. Here, ‐2D, grown on graphene on Ir(110), is established as a first single‐layer A‐type antiferromagnet. Spin‐polarized s...

Ultra-compact plasma photocathode in a hybrid wakefield accelerator

Abstract Plasma-based particle accelerators, realized by driving plasma waves with either an intense laser pulse or particle beam, offer accelerating fields orders of magnitude higher than conventional accelerators. This enables sources of highly relativistic electron beams with...

Disentangling surface and bulk properties of Ta3N5 photoanodes

Abstract Understanding how material and defect characteristics govern photoelectrochemical performance is essential for developing efficient and stable photoelectrodes. Although bulk properties are often emphasized, surfaces and interfaces can equally determine activity and stabi...

External validation of a top-ranked model from the RSNA pulmonary embolism detection challenge: assessment of generalizability

Abstract To externally validate the RSNA 2020 challenge 2 nd -place deep-learning (DL) algorithm for detecting pulmonary embolism (PE) on computed tomography pulmonary angiography (CTPA) scans with additional focus on subsegmental-only PEs (SSPE). Between 2015 and 2022 1,038 CTPA...

Bioinspired Large-AreaPolymeric Cucurbituril Monolayerswith Ultrahigh-Density Nanopores Enabling Reversible Charge-Gatingof Ion Transport via Host–Guest Recognition

Abstract Achieving precise control over ion and molecular transport under subnanometer confinement, especially beyond passive sieving, remains challenging in nanofluidics and membrane science. Here, we present a bioinspired strategy that enables the formation of subnanometer chan...