Health Net

Crystalline maculopathy as a clue to a neurocutaneous syndrome

PURPOSE: To describe crystalline maculopathy as a diagnostic clue to Sjögren-Larsson syndrome (SLS) and highlight characteristic multimodal imaging findings. METHODS: Case Review. RESULTS: Using multimodal imaging, including OCT and fundus autofluorescence, we provide detailed st...

Sex differences in concussion incidence before and during the COVID-19 pandemic: a population-based study (2017–2022)

OBJECTIVES: This population-based retrospective study investigated the impact of sex on annual case counts and incidence rates of concussions before and during COVID-19 pandemic. METHODS: Using administrative data from ICES, we identified 393,397 individuals with concussion betwe...

Audit of the psychiatric extended care model’s impact on emergency department length of stay

Objective Prolonged Emergency Department (ED) Length of Stay (LOS) for mental health patients adversely impacts bed flow. This study evaluated the Psychiatric Extended Care (PEC) model’s PEC-C pathway, implemented at Lyell McEwin Hospital in June 2022, which transfers select pati...

Synthetic Patient Record Configurator and Adaptation Guide

A single-file browser application that assembles prompts for the generation and review of synthetic clinical records. It encodes the procedural knowledge of one service, a community mental health transfer of care caseload in South Australia, accumulated through the iterative gene...

The Forcing Factors That Predict Obesity: A Cross‐Sectional Multilevel Machine Learning Model of US County‐Level Prevalence

OBJECTIVE: Variables predicting obesity are not limited to individual-level risk factors. The purpose of this study is to assess multilevel predictors of obesity prevalence. METHODS: US county-level datasets incorporating 34 variables were analyzed cross-sectionally using explain...

Adapting computerised language sample analysis for Jamaican Creole-Jamaican English-speaking preschoolers: A pilot study

This pilot study examines the feasibility of adapting the Systematic Analysis of Language Transcripts (SALT) for Jamaican Creole-Jamaican English-speaking preschoolers. Standard SALT protocols, designed for monolingual English speakers, risk misrepresenting bilingual children's l...

Immune checkpoint blockade sensitivity is linked to endogenous retroelement transcriptional changes in cancer

Abstract Endogenous retrotransposable elements (EREs) can modulate immune responses. We explored ERE transcription in relation to response to immune checkpoint inhibition in advanced solid tumors. ERE expression was measured in pre and on-treatment samples from patients treated i...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Narcissism re-framed as a superiority motive: unifying evolutionary and clinical perspectives

Objective Narcissism is commonly described through grandiosity, entitlement, admiration seeking, exploitation and impaired empathy. This perspective article proposes that these features can be clinically organised around a common function: the regulation of felt superiority. Conc...

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

OBJECTIVE: Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable...