Health Net

Immune checkpoint blockade sensitivity is linked to endogenous retroelement transcriptional changes in cancer

Abstract Endogenous retrotransposable elements (EREs) can modulate immune responses. We explored ERE transcription in relation to response to immune checkpoint inhibition in advanced solid tumors. ERE expression was measured in pre and on-treatment samples from patients treated i...

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

OBJECTIVE: Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable...

Narcissism re-framed as a superiority motive: unifying evolutionary and clinical perspectives

Objective Narcissism is commonly described through grandiosity, entitlement, admiration seeking, exploitation and impaired empathy. This perspective article proposes that these features can be clinically organised around a common function: the regulation of felt superiority. Conc...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...