Health Canada

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

“Whatever time they show up is the right time”: a Canada-wide qualitative analysis of client, provider, and administrator perspectives on person-centered and equitable substance use disorder care

Canada’s unregulated drug supply continues to impose severe harms on people living with opioid use disorder (OUD). While opioid agonist therapy (OAT) is an effective intervention, fewer than 30% of people with OUD initiate treatment and fewer than half remain engaged beyond six m...

Small modular reactors and our ecosystems – engagement, transparency & trust; summary of a workshop held at McMaster University, Canada

Purpose: Globally, governments are launching national programs, demonstration projects and industrial partnerships to bring small modular reactors (SMR) to market as lower-carbon, more flexible forms of nuclear power. Current international assessments suggest the first wave of co...

Sex-specific toxicological observations following 28-day oral gavage exposure to spherical and milled polystyrene nano- and microplastic particles in mice

Abstract Background With the rise in global plastic production, microplastics are an emerging environmental pollutant due to their ubiquitous presence in the environment. Human exposure and the impact of microplastics on human health warrants further research. Recent studies have...

Microbiological and genomic approaches to study and characterize co- and cross-resistance to antimicrobial peptides in Listeria monocytogenes ATCC 19,111 variants

Abstract Background Antimicrobial peptides are considered a promising alternative to conventional antibiotics for controlling Listeria monocytogenes , a major foodborne pathogen. However, the emergence of antimicrobial resistance, including co- and cross-resistance between struct...