Haukeland University Hospital

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Endoscopic radiofrequency ablation for unresectable cholangiocarcinoma: a single-centre retrospective cohort study with patient interviews

BACKGROUND: This study assessed biliary drainage durability, survival, and patient experiences following endoscopic retrograde cholangiopancreatography (ERCP)-guided radiofrequency ablation (RFA) plus stenting for palliation in unresectable cholangiocarcinoma (CCA). METHODS: Ten...

New and emerging therapeutics and molecular targets for attention-deficit hyperactivity disorder

INTRODUCTION: Attention‑deficit hyperactivity disorder (ADHD) is defined by persistent, impairing, and developmentally inappropriate patterns of inattention and/or hyperactivity/impulsivity. ADHD is a multifactorial, partially heritable and polygenic disorder, involving multiple...

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

Sense of coherence and rehabilitation outcomes: a 3-year longitudinal study

OBJECTIVES: To examine Sense of Coherence over a 3-year period and investigate whether baseline levels and changes in Sense of Coherence are associated with rehabilitation outcomes. DESIGN: Longitudinal cohort study. PARTICIPANTS: Patients accepted for specialized rehabilitation...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

The Pretherapy Endothelial Activation and Stress Index (EASIX) in Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study

Background/Objectives: The endothelial activation and stress index (EASIX; serum creatinine times lactate dehydrogenase/peripheral blood platelet count) seems to reflect endothelial cell activation/dysfunction. Furthermore, endothelial cells support acute myeloid leukemia (AML) c...

From Fear to Function: How Physiotherapists Navigate Psychological Challenges in Patients Undergoing Rehabilitation After ACL Reconstruction

Background: Psychological readiness plays a critical role in return to sport (RTS) outcomes after anterior cruciate ligament reconstruction (ACLR), yet physiotherapists (PTs) often feel unprepared to support this aspect of recovery. Although clinical guidelines advocate for psych...

Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk

Abstract Background Season at birth has been associated with increased risk for psychotic disorders. Epigenetic markers, which can be influenced by environmental exposures, may help to understand the mechanisms of seasonal effects. Aims To investigate two types of seasonal influe...

Filling the gaps in high-priority reference materials for implementing metrological traceability in laboratory medicine

Abstract The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of reference measurement systems, including suitable certified reference materials (CRMs). There are, however, a relatively small number of CRM producers...

Transverse Myelitis and Guillain–Barré Syndrome in Pediatric Lymphoid Malignancies: An International Retrospective Study

Central and peripheral neurotoxicity after methotrexate is a rare but challenging complication of therapy for pediatric lymphoid malignancies. In this Ponte-di-Legno Toxicity Working Group and international Berlin-Frankfurt-Münster Group study, we describe nine children and adole...

What are the Unmet Needs in Managing Digestive Neuroendocrine Carcinomas?

This review highlights the major unmet needs in diagnosis and treatment of digestive neuroendocrine carcinomas (NEC) and describes the current and evolving evidence on these aspects. Improved pathological criteria are needed to accurately diagnose NEC and distinguish this entity...

Pica, avoidant restrictive food intake disorder and rumination disorder in children and adolescents with autism spectrum disorder: A systematic review

Abstract Background Children with autism spectrum disorder (ASD) have an increased risk of co-occurring eating disorders such as pica, avoidant restrictive food intake disorder (ARFID) and rumination disorder (RD). The aim of the current systematic review was to synthesize and ap...

Elucidating the role of pre-existing immunity in mucosal lymphoid architectural dynamics following live attenuated influenza vaccination

Mucosal immune responses in the upper respiratory tract are central to preventing influenza infection. The live attenuated influenza vaccine (LAIV) is delivered intranasally, making it a valuable model for investigating mucosal immunity in humans. In this study, we examined struc...

Pattern-Anchored Diagnosis of Oral Epithelial Dysplasia: A Position Paper From COST Action INTERCEPTOR Working Group 2

Abstract Purpose Oral epithelial dysplasia (OED) is the principal histopathological marker for malignant risk stratification in oral potentially malignant disorders (OPMDs). Current World Health Organisation (WHO) three-tier and other binary grading systems are limited by modest...

Patients’ Mental Barriers in Rehabilitation after ACL Reconstruction: A Qualitative Interview Study

Background Recovery after anterior cruciate ligament reconstruction (ACLR) involves both physical and psychological challenges. Although psychological readiness for return to sport (RTS) is increasingly recognized as important, less is known about how patients experience psycholo...

Classification of type 1 diabetes and type 2 diabetes based on administrative registry data: a nationwide study from Norway

Abstract Background Type 1 diabetes (T1D) and type 2 diabetes (T2D) differ in health care needs, and precise prevalence estimates by diabetes type are important for health care planning. Data and Methods Using Norwegian health registry data on diagnoses from primary and specialis...

OA03-RF01.05. The Safety and Efficacy of Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma in Scandinavia (SEES-Study)

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Endoscopic submucosal dissection (ESD) is recommended for early-stage esophageal squamous cell carcinoma (ESCC). Most data on the efficacy of ESD for ESCC comes...