Harvard University Press

A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer

Lineage-defining transcription factors are key oncogenic drivers but remain difficult to target pharmacologically due to the absence of ligandable pockets. The molecular rules governing substrate recognition by large HECT ubiquitin ligases also remain incompletely understood, lim...

Flourishing Childhood Frameworks: A Scoping Review

OBJECTIVES: Experiences in early life impact childhood, lifelong flourishing, and overall well-being. Yet a framework to guide promoting and measuring flourishing in early childhood has not emerged. The objective of this study was to identify frameworks and measures related to pr...

Decoupling Ecological and Pathogenic Roles: Helicobacter pylori as a Gastric Hegemon Maintaining Order or Amplifying Dysbiotic Chaos

Abstract Gastric dysbiosis refers to disease-associated alterations in microbial composition and between-individual variability. We postulate that Helicobacter pylori (H. pylori or Hp) exerts a context-dependent ecological effect across the Correa cascade—the histopathological pr...

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments

Abstract The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in industrialized settings; nevertheless, APOE ε4—which is ancestral in humans—has persisted o...

Pop, Crackle, Snap (and Pow): Some facets of shards

Reading cut the hyperplanes in a real central arrangement \mathcal{H} into pieces called shards , which reflect order-theoretic properties of the arrangement. We show that shards naturally index certain generators of the fundamental group of the complement of the complexification...

Current and Future Directions for Responsible Quantum Technologies: A ResQT Community Perspective

Abstract Quantum technologies (QT) are advancing rapidly, promising advancements across a wide spectrum of applications but also raising significant ethical, societal, and geopolitical impacts, including dual-use capabilities, varying levels of access, and impending quantum divid...

Sex and Self-reported Race: Factors Associated with Anal Mucosal Melanoma and Anal Mucosal Pigmentation?

Anal canal melanoma (ACM) is a rare, aggressive malignancy with an ominous prognosis. However, its associated factors are largely unknown. Therefore, we investigated potential independent associations of sex and self-reported race with ACM and physiological anal canal pigmentatio...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Numerous Overlapping Programs Add Complexity, Unpredictability to Rural Hospital Finances

Abstract Introduction Rural hospitals face unique financial challenges, prompting Congressional action including multiple Medicare-specific payment programs. Medicare’s programs to enhance rural hospital payment include: Critical Access, Sole Community, Medicare-Dependent, and Lo...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Not Learning from Others

We study social learning using experiments where two people independently learn relevant information and can share it to make accurate private decisions. Across three experiments, people are substantially less sensitive to information others discover than to equally-relevant info...

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

ABSTRACT Cardiovascular disease (CVD) continues to be a significant contributor to premature mortality and the financial burden of healthcare. Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) are increasingly utilized to investigate patient‐specific genetic...

Nietzsche on Decadence as Freedom

This article offers a new reading of decadence in Nietzsche, not as a time of despair or sclerosis, but as one of individuality and freedom. It does so by focusing on decadence’s emancipatory potential for exceptional individuals. For Nietzsche, the best philosophers, artists, an...

Optimal Public Transportation Networks: Evidence from the World's Largest Bus Rapid Transit System in Jakarta

Designing public transport networks involves trade-offs between coverage, service frequency, and direct service. We use the expansion of the bus system in Jakarta, Indonesia, to study these trade-offs. We analyze how new direct connections, changes in bus travel time, and wait-ti...

Harmonizing Safety and Speed: A Human-Algorithm Approach to Enhance the FDA’s Medical Device Clearance Policy

The United States Food and Drug Administration (FDA)’s 510(k) pathway allows manufacturers to gain medical device approval by demonstrating substantial equivalence to a legally marketed device. However, the inherent ambiguity of this regulatory procedure has been associated with...

Presidential Address: Neighborhood Effects and Missing Markets for Opportunity

Experimental and quasi-experimental studies show that childhood neighborhoods have substantial causal impacts on children's adult earnings and other long-term socioeconomic outcomes. Several market failures are likely to lead to excessive residential segregation by parental incom...

ENSO-driven multi-decadal climate variability in Auckland: a Southern Hemisphere coastal city perspective

Coastal cities in Southern Hemisphere mid-latitudes face climate risks from interacting tropical and polar atmospheric systems. This study examines multi-decadal climate variability in Auckland (37°S), New Zealand’s largest city, using 1963–2022 records. Morlet wavelet analysis a...

The Reading Brain from Womb to Classroom: Typical and Atypical Development and Implications for a Preventative Education Model

Learning to read is a process and milestone with far-reaching implications for education, vocation, and health. Most models and empirical studies of reading development, however, focus on school entry and often limit potential influences to children's oral language and print-base...

Making the case for massive islands

A bstract It has been established in both high and low spacetime dimensions that existing constructions of entanglement islands, at least in the study of black holes, are all in the context of massive gravity. In fact, later studies realized that the graviton mass is not an accid...

Association of prenatal exposure to opioids, cannabis, and polysubstance use with cord blood DNA methylation patterns in a multiancestry cohort

Abstract Background: Blood DNA methylation patterns are highly predictive of prenatal exposure to smoking and differential methylation has been associated with maternal alcohol use. We extended this to determine whether DNA methylation patterns in cord blood are associated with p...