Hangzhou Medical College

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

Enzymatic cross-linking collagen-based bioink for 3D bioprinting of endometrial model with endometrial epithelial organoids

The human endometrium, a dynamic tissue responsive to sex hormones, plays a pivotal role in female reproduction and menstrual cycling, comprising diverse cell populations including epithelial and stromal cells. The development of in vitro endometrial models holds substantial pote...

Prognostic biomarkers in non‐muscle‐invasive bladder cancer: biological basis and evidence

Objectives To review prognostic and treatment‐response biomarkers for non‐muscle‐invasive bladder cancer (NMIBC), with particular attention to biological function, specimen type, assay method, statistical evidence, and possible clinical use. Methods We conducted a focused narrati...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Integrated Proteomic and Phosphoproteomic Profiling Reveals Dysregulated Inflammatory Signaling Networks in Rheumatoid Arthritis

Aberrant protein phosphorylation orchestrates sustained inflammatory immune signaling in rheumatoid arthritis (RA), yet the coordinated remodeling of proteomic and phosphoproteomic landscapes in peripheral blood mononuclear cells (PBMCs) remains poorly resolved via system-level m...

Analytical performance and clinical classification value of a novel sandwich immunoassay for total testosterone measurement in low-concentration and hemodialysis populations

Abstract Objectives To evaluate the analytical performance and clinical classification value of a novel sandwich testosterone immunoassay, particularly for biochemical testosterone elevation in women and deficiency in male hemodialysis patients, using LC–MS/MS as the reference me...

Synergistic microbiologically influenced corrosion of SLM TC4 by co-culture of Streptococcus mutans and Veillonella dispar

Ti-6Al-4V (TC4) is extensively utilized for oral implants due to its excellent mechanical properties and biocompatibility. In the oral environment, microbiologically influenced corrosion (MIC) is typically driven by multispecies biofilms. Here, electrochemical, surface, and corro...

Dual-targeted nanotechnology for gynaecological cancers: a comprehensive review of mechanisms and clinical potential

Background Ovarian, cervical and endometrial cancers have been the leading cause of morbidity and mortality in women, often resulting from late diagnosis, resistance to therapies and off-target toxicity of conventional therapies.Discussion The review discusses recent progress in...

Autism spectrum disorder burden in China and worldwide, 1990–2021

Autism spectrum disorder (ASD) imposes a substantial public health burden. This study quantified and compared the ASD burden in China and globally from 1990 to 2021 to inform policy and planning. We analyzed Global Burden of Disease 2021 estimates of age-standardized prevalence r...

Living environmental quality and incident depressive symptoms among middle-aged and older adults in China: a national longitudinal study

Depressive symptoms are common in mid-to-late adulthood in China. Evidence linking living environments to depression has often focused on single exposures, and prospective evidence on the association between an integrated measure of living environmental quality (LEQ) and subseque...

Nanozyme‐Assisted Engineered Oncolytic Adenovirus for Improving Intratumoral Immune Deficiency and Enhancing Cancer Immunotherapy

ABSTRACT Oncolytic adenovirus (OA) exhibit tumor‐selective tropism, inducing direct oncolysis while simultaneously potentiating host immune responses against malignancies. However, the poor delivery efficiency of the virus targeting tumors and its limited immune activation capaci...

Construction of a drug screening model for Mycobacterium abscessus infections

Abstract The management of Mycobacterium abscessus infections is critically hindered by its inherent multidrug resistance and the lack of effective therapies, necessitating advanced preclinical models for drug discovery. Here, we developed a sequential screening platform, progres...

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

Life-stage-resolved toxicological assessment and environmental relevance of triclosan in the freshwater gastropod Biomphalaria glabrata

TCS (triclosan) is frequently detected in freshwater compartments, including surface water, sediments, biosolids, and pore water; however, its life-stage-specific toxicity in gastropod mollusks remains insufficiently characterized. To address this gap, this study aimed to determi...

Performance of a five-gene plasma cfDNA methylation assay for colorectal cancer detection: a single-center real-world analysis

Blood-based circulating cell-free DNA (cfDNA) methylation assays have been proposed as minimally invasive tools for colorectal cancer (CRC) detection, but their performance under routine clinical conditions may differ from model-development studies. We evaluated the real-world di...

Osteoclast precursor cell membrane-engineered bone-targeting calcium carbonate nanoparticles for anti-osteoporosis therapy

Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mass and deterioration of bone microarchitecture, resulting in an increased risk of fragility fractures. Current anti-osteoporotic therapies are often limited by poor targeting efficiency, suboptimal ther...

A Macromolecule npEt20 Exerts Broad-Spectrum Synergistic Effects With Meropenem Against Multidrug-Resistant Gram-Negative Pathogens

Background: The widespread emergence of multidrug-resistant (MDR) Gram-negative bacteria severely compromises the clinical efficacy of carbapenem antibiotics, leading to refractory nosocomial infections. Novel antibacterial agents that can reverse carbapenem resistance are urgent...

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Photochemical Synthesis of 1-Propyl-3-phenylquinoxalin-2(1 H )-one: An Undergraduate Laboratory Experiment

Abstract 3-Arylquinoxaline-2(1H)-ones are significant scaffolds in medicinal chemistry due to their diverse biological and pharmacological activities, such as neuroprotective and anti-cancer activities. While photo-induced synthesis has emerged as a sustainable approach to these...