Hangzhou Medical College

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

ABSTRACT Iron–sulfur (Fe–S) clusters are pivotal molecular cofactors bridging inorganic chemistry and organic life processes, with their tightly regulated biosynthesis and function underpinning cellular metabolic homeostasis. Chronic alcohol‐induced metabolic stress impairs Fe–S...

Polygonum cuspidatum Exosome‐Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK ‐Mediated PASMC Phenotypic Switching

Hypoxic pulmonary hypertension (HPH) is characterized by excessive proliferation of pulmonary vascular cells, ultimately resulting in right heart failure and death. Although resveratrol, an active component of Polygonum cuspidatum (PC), has shown efficacy against HPH, the mechani...

Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis

Astaxanthin, a marine-derived carotenoid, has shown antioxidant and anti-inflammatory properties in studies. However, its effects on cardiometabolic risk factors in overweight and obese populations remain inconclusive. Therefore, this systematic review and meta-analysis aimed to...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...

Identification of Erectile Dysfunction From Routine Blood Test Data: Development and Validation of a Machine Learning‐Based Prediction Model

BACKGROUND: Erectile dysfunction (ED) is a prevalent male health disorder and a recognized sentinel marker for cardiovascular disease. Current diagnostic reliance on subjective questionnaires or invasive examinations limits early screening. AIM: We aimed to develop and validate a...

Demographic time bomb in COPD (1990–2050)

Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality, characterized by irreversible airflow limitation and progressive symptoms. Despite declining age-standardized rates (ASRs), absolute burdens are rising due to population aging and g...

Hyperspectral Camera Imaging Tandem With HPLC‐UV‐ELSD Determination and Cell Bioassay for Geographical Discrimination and Quality Consistency Evaluation of Anoectochilus roxburghii

ABSTRACT Introduction Anoectochilus roxburghii (AR) is a prized medicinal herb valued for its hepatoprotective effects. Its quality varies depending on geographical origin. The primary bioactive constituents include rutin, quercetin‐7‐ O ‐glucoside, kaempferol‐3‐ O ‐rutinoside, n...

A dual-mode radiofrequency ablation catheter with advanced thermal sensing for saphenous and perforator vein insufficiency: a preclinical study on goats

为克服现有进口器械热损伤风险高、 与国内临床常用的 6 Fr 鞘管不兼容等局限性, 我们研发了一款名为 Saphenus 的新型国产射频消融 (RFA) 导管系统。 其核心创新点包括: 6 Fr 外径设计 (适配国内常用鞘管), 独特的双模工作长度设计 (8 mm 用于穿通静脉, 80 mm 用于大隐静脉), 以及优化的温度传感机制以...

hESC-MSC-EVs attenuate post-cardiac arrest brain injury by inhibiting cGAS/STING-mediated neuronal pyroptosis

Cardiac arrest-induced brain injury significantly affects patient prognosis, yet effective therapeutic strategies remain lacking in clinical practice. In recent years, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have garnered considerable attention for their no...

Surgery is associated with improved survival in elderly patients with gastric cancer based on a competing risk analysis of the SEER database

Abstract Background Gastric cancer (GC) is one of the most common malignancies worldwide and occurs with a particularly high incidence in the elderly population. Given the substantial burden of comorbidities and the elevated risk of non–cancer-related mortality in older patients,...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

AnEnergy-Sustainable and Oxidative-Tolerant Nanofactoryof Therapeutic Proteins for Long-Acting Therapy of Inflammatory BowelDisease

Abstract The ability to continuously generate bioactive therapeutics at the diseased site is an appealing and crucial advantage for the treatment of chronic relapsing diseases such as inflammatory bowel disease (IBD). Current in situ therapeutic factory strategies mainly rely on...

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Abstract Obesity is a key risk factor for diabetic kidney disease (DKD). However, BMI fails to capture body fat distribution. We hypothesized that central obesity, rather than generalized obesity, is associated with DKD risk in patients with type 2 diabetes mellitus (T2DM), and t...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

An Adaptive In SituBiointerfacial Armoring Platformfor Long-Term Gut Microbiota Modulation

Abstract Despite the immense potential against diverse chronic inflammatory and metabolic disorders, the clinical translation of microbial therapies is largely thwarted by the delivery challenges of live biotherapeutics. Probiotics often succumb to harsh gastrointestinal conditio...

Plant‐Derived Extracellular Vesicle‐Like Nanoparticles and Decoction Nanoparticles Exhibit Distinct Therapeutic Effects in Alcoholic Liver Disease via Gut Homeostasis and Macrophage Regulation

Nanoparticles originating from plants have attracted increasing attention owing to the excellent biocompatibility and high potential in disease prevention. Various types of plant-derived nanoparticles have been extensively studied; however, comparative investigations of different...