Hamedan University of Medical Sciences

Antileishmanial potential of polar fractions from Amaranthus blitoides S. Watson, Caucalis platycarpos L., and Cistanche flava (C.A.Mey.) Korsh.: evidence from in vitro and in vivo studies

BACKGROUND: Cutaneous leishmaniasis (CL) is recognized by the World Health Organization (WHO) as a research priority, yet its treatment remains challenging. CL lesions arise from complex interactions between the parasite and host immunity, where excessive inflammation can delay h...

Preliminary molecular characterization of Blastocystis sp. subtypes among IBS patients and non-IBS individuals in Hamadan Province, western Iran

Blastocystis sp. is a common protozoan parasite in humans and has frequently been implicated in gastrointestinal disorders such as irritable bowel syndrome (IBS). This study aimed to preliminarily characterize and descriptively compare the distribution of Blastocystis subtypes am...

Are all dental procedures equally high risk for aerosol generation? Evidence from a clinical experimental study

Aerosols and droplets generated during dental procedures represent a critical challenge for infection control and occupational safety. This study aimed to identify dental procedures and instruments associated with the highest aerosol and droplet production and to evaluate the eff...

Co-production of ESBL and OXA-48 in 3 of 67 isolates, with a unique NDM-1/OXA-48 co-producing strain from a pediatric ALL patient: a case series

Abstract Background Antibiotic resistance poses a major challenge in treating bloodstream infections (BSI) from Escherichia coli in patients with leukemia. Imipenem, a carbapenem antibiotic and, is considered an effective option for treating bloodstream infections in patients wit...

Machine-learning prediction of cardiovascular diagnoses from pediatric ECG reports in 11 643 children

Cardiovascular disease (CVD) in children is heterogeneous, often paucisymptomatic, and easily missed at first contact, yet the electrocardiogram (ECG) remains the most widely available cardiac test. In routine care the ECG is stored and exchanged as a structured report rather tha...

The moderating role of organizational intelligence on the relationship between knowledge management and healthcare service quality in Iranian hospitals

Modern healthcare systems face mounting challenges stemming from technological advancements, rising patient expectations, and the growing imperative to integrate evidence-based data into clinical practice. Although effective Knowledge Management (KM) is widely recognized as essen...

Dual topical therapy with doxepin and allopurinol mouthwash for severe methotrexate-induced oral mucositis: a pediatric case report

High-dose methotrexate (HD-MTX) is a cornerstone of chemotherapy for pediatric osteosarcoma but frequently induces severe oral mucositis, a dose-limiting toxicity characterized by painful ulceration and impaired oral function. While standard supportive care includes leucovorin re...

Antibacterial and antibiofilm properties of 1,3,4-oxadiazoles against multidrug-resistant Pseudomonas aeruginosa isolated from burn infections – an in vitro study

Pseudomonas aeruginosa is a major causative agent of burn wound infections, frequently characterised by multidrug resistance (MDR) and robust biofilm formation, which limit the efficacy of conventional antibiotics. 1,3,4-Oxadiazole derivatives have emerged as potential antimicrob...

Complex interactions between miR-107 and PTEN gene expression, more specifically in viral and NASH cirrhosis

Background microRNAs play critical roles in modulating the molecular pathways involved in liver fibrosis. miR-107 has been reported to be elevated in the liver of patients with non-alcoholic fatty liver disease (NAFLD), and it is believed to regulate the PTEN gene, a negative reg...

Over reliance on prior expectations in relapsing remitting multiple sclerosis

Abstract Cognitive impairment is a common and disabling feature of multiple sclerosis (MS). Bayesian models of perception and action provide a powerful framework to better understand how cognitive processes are altered in MS. In this case-control study, we employed a time reprodu...

Dental caries experience in first permanent molars and its associated factors among Iranian primary school-aged children: a cross-sectional study

Abstract Background Dental caries in first permanent molars is a highly prevalent condition in primary school-aged children and represents a substantial oral health burden in Iran. This study aimed to assess dental caries experience, based on the decayed, missing, and filled teet...

Hepatic steatosis assessed by transient elastography in patients with significant coronary artery disease: a cross-sectional study

While metabolic dysfunction-associated steatotic liver disease (MASLD) and coronary artery disease (CAD) share metabolic risk factors, it remains unclear whether the anatomical severity of CAD predicts the severity of hepatic steatosis or fibrosis. This study aimed to estimate MA...

Evaluation of oxidative stress level: total antioxidant capacity, malondialdehyde and superoxide dismutase activity in children with pneumonia compared to healthy children

Viral pneumonia is a leading cause of death in young children worldwide. Oxidant/antioxidant imbalance has been reported in various infectious diseases. This study aimed to evaluate oxidative stress and antioxidant defense markers — specifically malondialdehyde (MDA), total antio...

Central role of vapBC toxin–antitoxin system expression in the pathogenicity and antimicrobial resistance of Shigella sonnei isolates from pediatric diarrheal patients

Shigella sonnei , a Gram-negative bacterium, has been identified as a primary causative agent of gastrointestinal disease in humans. Antibiotic resistance has emerged as a critical concern in the context of Shigella species, thereby complicating the effective treatment of shigell...

Examining the performance of the EMS system during the COVID-19 pandemic: a cross-sectional study in Iran

In many countries, the Emergency Medical Services (EMS) serve as the frontline of healthcare systems, playing a critical role in responding to health emergencies, including epidemics and pandemics. Assessing the current preparedness and performance of the EMS, along with regular...