Hamad Medical Corporation

HPV vaccination and cervical cancer deaths: from incidence reduction to mortality prevention

Abstract Persistent infection with carcinogenic human papillomavirus (HPV) types causes the great majority of cervical cancers. For more than a decade, randomized trials, surveillance studies, and national registry analyses have demonstrated reductions in vaccine-type HPV infecti...

Oral tebipenem pivoxil for complicated urinary tract infections: evidence, potential role in IV-to-oral transition, and antimicrobial stewardship

Abstract Purpose Complicated urinary tract infections (cUTIs), including pyelonephritis, are increasingly challenging when resistant Enterobacterales eliminate conventional oral treatment options. Tebipenem pivoxil (UTEBZI), approved by the US Food and Drug Administration in June...

Zero-touch technique: a new paradigm in penile prosthesis surgery enabled by a sterile genital barrier system

Abstract Penile prosthesis (PP) implantation remains the most definitive treatment for medication-refractory erectile dysfunction (ED). Despite reductions in infection rates achieved through improved PP coatings, antimicrobial protocols, and refined surgical techniques, PP infect...

Gene Expression Biomarkers for Breast Ductal Carcinoma in Situ Recurrence Prediction

ABSTRACT Breast ductal carcinoma in situ (DCIS) is often overtreated due to a lack of robust prognostic and predictive tools. This study aimed to evaluate gene expression in a well‐characterised DCIS cohort to determine their clinical utility as biomarkers for ipsilateral recurre...

A Rare Entity in Context: Breast Implant-Associated Anaplastic Large Cell Lymphoma Compared With Common Lymphoma Subtypes

Objective: edition World Health Organization Classification of haematolymphoid tumors. Its clinicopathologic profile, treatment patterns, and outcomes, relative to those of other primary breast lymphomas, have not been characterized in large population-based comparative studies....

Kidney cancer in Eastern Mediterranean Region and Qatar: epidemiological burden patterns and etiologic risk pathways

Abstract Kidney cancer contributes substantially to the global cancer burden, with significant geographic and sex differences. Countries in the Eastern Mediterranean Region (EMR) show rising incidence and mortality alongside gaps in registry coverage and high prevalence of metabo...

Effect of a tele-orthodontics platform on knowledge, attitudes, and practices among orthodontic professionals in Yemen: a single-arm pretest–posttest intervention study

Abstract Objectives To evaluate the effect of a tele-orthodontics platform on orthodontists’ and orthodontic residents’ knowledge, attitudes, and practices (KAP) in Yemen, as well as to assess the platform’s acknowledged benefits, obstacles, and consultants’ responsiveness. Metho...

Ethical Governance of Open Data Across Biomedical Research, Healthcare, and Public Health: Privacy, Equity, Trust, and Controlled Access

Open data has become central to biomedical research and public health, but health information is uniquely sensitive and difficult to share responsibly. In this narrative review, open data is considered as a spectrum of health-data sharing arrangements, ranging from public aggrega...

Acute fibrinous and organising pneumonia (AFOP): a case series highlighting diverse aetiologies and clinical outcomes in three patients

Background Acute fibrinous and organising pneumonia (AFOP) is a rare histopathological pattern of acute lung injury characterised by intra-alveolar fibrin deposition and organising pneumonia. It has diverse aetiologies and highly variable clinical outcomes.Case presentations We r...

Efficacy and safety of chimeric antigen receptor T-cell therapy in primary central nervous system lymphoma: a systematic review and meta-analysis

Background Evidence for chimeric antigen receptor T-cell (CAR-T) therapy in primary central nervous system lymphoma (PCNSL) remains limited and heterogeneous, with prior syntheses often combining primary and secondary CNS lymphoma.Methods We systematically searched PubMed, Scopus...

Effectiveness of Flipped Classroom and Traditional Didactic Classroom in Paediatric Dentistry Education—A Systematic Review With Meta‐Analysis of Randomised Controlled Trials

ABSTRACT Introduction The flipped classroom (FC) is a contemporary teaching strategy that has gained considerable attention in recent years. This model relies on technology‐based resources, including videos and handouts, to deliver illustrative content and core subject material t...

Carvedilol for prevention of cardiotoxicity in patients receiving anthracycline-based chemotherapy: a systematic review and meta-analysis

Chemotherapy-induced cardiotoxicity, particularly from anthracyclines, limits treatment in oncology patients. Carvedilol, a third-generation β-blocker with antioxidant properties, may offer cardio protection. However, comparative evidence for carvedilol and its metabolites remain...

Atherogenic lipid profile changes and their cardiovascular consequences across degrees of obesity in children and adolescents: a structured narrative review

Key messageChildren and adolescents with obesity commonly develop atherogenic dyslipidemia characterized by elevated triglyceride, reduced high-density lipoprotein cholesterol (HDL-C), and elevated non-HDL-C levels, and increased triglyceride/ HDL-C ratio.This pattern worsens wit...

International Travel for Organ Transplantation: 2024 Multinational Survey of Routes, Organs, and Donor Types

BACKGROUND: International travel for organ transplantation (ITOT) reportedly affects ≥2% of global solid organ transplant activity, yet detailed information about ITOT participants, organ types, travel configurations, and clinical settings remains scarce. Previous research has fo...

The Proteinase Activated Receptor-2 mediates Protective Immunity in Early Experimental Leishmaniasis

Resistance to Leishmania (L.) major depends on the development of a L. major-specific Th1 response, while Th2 differentiation results in susceptibility. We previously showed that the early microenvironment of infected skin delivers important signals for T cell differentiation. We...

Use and perceived utility of ChatGPT among participating medical students in selected MENA settings: a cross-sectional survey

ChatGPT is a language model, developed by OpenAI, that uses contextual understanding that allows it to generate relevant responses based on current input and previous context. ChatGPT has infiltrated many fields, including medicine. As the demand for medical education tools is in...

Holistic segmentation of minimally-invasive robotic surgical scenes using feature-adaptive localization

Holistic surgical scene segmentation is vital for training novice surgeons in robotic minimally invasive surgeries (RMIS). While the SegFormer model shows great potential due to its adaptability to various input image resolutions, the contrast between surgical instruments and ana...

Comprehensive AI workflow for radiological report generation from radiographs

The manual generation of radiology reports is time-consuming and error-prone, particularly for less experienced radiologists, leading to inefficiencies and delays in clinical workflows as case volumes increase. Therefore, automated radiology report generation can serve as valuabl...

Hierarchical Redistribution of Spatial Orientation Across the Eyes, Head, Trunk, and Body

Hierarchical Redistribution of Spatial Orientation Across the Eyes, Head, Trunk, and Body presents a theoretical framework in which the eyes, head, trunk, and whole body are treated as nested orienting platforms contributing to a common three-dimensional spatial objective. Horizo...

A retrospective comparative study comparing laparoscopic and robotic hiatal hernia repair: surgical outcomes, recurrence rate, and postoperative morbidity

Hiatal hernia repair is commonly performed using minimally invasive surgical techniques, including laparoscopic and robotic approaches. Although robotic surgery offers enhanced visualization and improved instrument dexterity, controversy remains regarding its superiority over con...