Hamad Medical Corporation

Dural Puncture Epidural, Standard Epidural, and No Epidural: Comparative Effects on Labor Progression and Neonatal Outcomes

Objective: To compare non-epidural labor, standard epidural analgesia, and dural puncture epidural analgesia with respect to labor progression, obstetric outcomes, analgesia-related outcomes, and neonatal results. Methods: This single-center retrospective observational cohort stu...

Can artificial intelligence improve precision dosing? a systematic review of narrow therapeutic index drugs

Abstract Background Precision dosing of narrow therapeutic index drugs remains challenging because of substantial interindividual variability and the narrow margin between therapeutic efficacy and toxicity. Artificial intelligence (AI)–based approaches may improve individualized...

Rollover motor vehicle crashes and occupant ejection: comparative analysis from a Middle Eastern trauma center

OBJECTIVES: Rollover motor vehicle crashes (ROCs) and occupant ejection (OE) are associated with worse outcomes. We studied the incidence, predictors, injury patterns, and outcomes of ROCs and OE in a rapidly developing country. METHODS: This was a retrospective analysis of the Q...

SGLT2 inhibitors and secondary polycythemia: a systematic review and meta-analysis of hematologic effects in patients with type 2 diabetes

Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used in the management of type 2 diabetes mellitus (T2DM) due to their survival benefits. However, these agents are associated with increases in hemoglobin (Hgb) and hematocrit (Hct), raising concern...

Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments

BACKGROUND: Early recognition of sepsis in emergency departments (EDs) improves outcomes and reduces healthcare resource use. However, current clinical practice (CCP), largely based on the National Early Warning Score 2 (NEWS2) and clinical judgement, has limited diagnostic sensi...

One‐Year Results of Accelerated Transepithelial Corneal Cross‐Linking for Progressive Keratoconus: A Prospective Interventional Study

ABSTRACT Background Keratoconus is a progressive corneal ectatic disorder. Accelerated transepithelial corneal cross‐linking (ATE‐CXL) aims to halt progression while preserving the epithelium, but evidence on its 12‐month efficacy requires further evaluation. Purpose To evaluate...

Cardiotoxicity and safety of zanubrutinib versus chemoimmunotherapy in chronic lymphocytic leukemia: a real-world retrospective cohort study using the TriNetX registry

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in the Western countries. Ibrutinib, a first-generation Bruton’s tyrosine kinase (BTK) inhibitor, is commonly used for relapsed/refractory CLL but is associated with cardiovascular adv...

Standard Antiplatelet Therapy Versus Thrombolysis in Acute Spontaneous Spinal Cord Infarction: A Propensity Score–Matched Analysis

BACKGROUND: Spinal cord infarction (SCI) is a rare stroke subtype with no established acute treatment guidelines. Thrombolytic therapy has been used empirically based on extrapolation from cerebral stroke protocols, but comparative effectiveness data are lacking. We compared outc...