Hacettepe University

Dietary intake, metabolic control and growth in patients with organic acidemia and urea cycle disorders

Organic acidemias (OA) and urea cycle disorders (UCD) require lifelong natural dietary protein restriction and, when needed, amino acid mixtures. However, evidence on the long-term effects of these nutritional interventions on growth, dietary adequacy, and metabolic control remai...

Comparison of caregiver burden and burnout levels in caregivers of individuals with cerebral palsy and stroke in similar functional conditions

The aim of this study is to compare the caregiver burden and burnout levels of caregivers of individuals with cerebral palsy (CP) and stroke who had similar functional independence levels, and to examine whether caregiver outcomes differed between these two caregiving contexts. T...

Dispersion modeling in Tweedie compound Poisson with combined actuarial neural networks

Accurate premium calculations in actuarial modeling are critical to the sustainability of insurance companies. Insurance portfolios are characterized by a nonnegative continuous distribution with a point mass at zero and considerable heterogeneity across policyholders. In this co...

Estimation of NATM excavation-support classes at tunnel excavation faces using a deep learning algorithm

Accurate determination of the geotechnical conditions at the tunnel face is essential for ensuring safe and effective excavation and support operations during tunnel construction with New Austrian Tunnelling Method (NATM). Therefore, engineering geologists carefully and systemati...

Özel Amaçlı İmar Planlarının Çatışması Sorunu ve Bazı Çözüm Önerileri

Özel amaçlı imar planları özel imar rejimine tabi kılınmış coğrafi alanların özel imar düzenini belirleyen planlardır. Bu planlar İmar Kanunu dışında kendi özel kanunlarında yer alan düzenlemelere tabidir. Mevzuata bakıldığında özel amaçlı imar planlarını ele alan çok sayıda fark...

Investigation of the Relationship Between Cognitive Emotion Regulation Strategies and Post-Traumatic Stress and Growth Levels

This study examined the differences in the relationships of Post-Traumatic Stress (PTS) symptoms and Post-traumatic Growth (PTG) levels with Cognitive Emotion Regulation Strategies (CERS). The sample consisted of 305 participants aged between 18 and 65 who reported experiencing t...

Design and Manufacturing of a Crankshaft-Free Compressor

The conventional crankshaft-driven reciprocating compressors inherently suffer from insufficient torque at the end of the compression due to their design. This study aims at designing and experimentally testing a crankshaft-free compressor in which the compression process is achi...

Overcorrection Provides Better Final Coronal Plane Alignment in Genu Varum Patients Treated With Tension-Band Plating and Followed Up to Skeletal Maturity

BACKGROUND: Genu varum deformity in skeletally immature patients can lead to long-term functional impairment and degenerative joint changes if untreated. Temporary hemiepiphysiodesis using tension-band plating is a widely accepted method for gradual correction; however, the rebou...

Definitive Chemoradiotherapy Versus Total Laryngectomy Followed by Postoperative Therapy in Selected T3–T4a N0–N1 Laryngeal Cancer: Comparative Outcomes

Background/Objectives: Management of locally advanced laryngeal squamous cell carcinoma remains controversial. This study compared definitive chemoradiotherapy (CRT) with total laryngectomy followed by postoperative radiotherapy with or without chemotherapy (TL + PORT/CRT) in T3–...

Investigation of the Effect of Nanoclay on Thermal and Dynamic Mechanical Properties of Poly( N -vinyl-2-pyrrolidone)/Dextran/Poly(ethylene glycol)-Based Nanocomposites

Abstract In this work, the effect of nanoclay content on the thermal and dynamic mechanical properties of the ternary polymer blend-based nanocomposites was investigated. The synergistic effect of combining poly(N-vinyl-2-pyrrolidone) (PVP), dextran (DEX), and poly(ethylene glyco...

Crescents and the Real Variable Cesàro Operator

Abstract This paper explores a version of the classical Cesàro integral operator for the Lebesgue space $$L^p(0, 1)$$ L p ( 0 , 1 ) where we discuss its norm, spectral properties, cyclicity, and invariant subspaces. The spectrum of the Cesàro operator will be a crescent domain wh...

Color Stability and Surface Roughness of Micro‐Layered, Polished, and Glazed Zirconia Exposure to Cigarette Smoke, Tea, and Coffee

OBJECTIVE: This study evaluated the effects of micro-layering glaze, polishing, and conventional glaze on the color stability and surface roughness of zirconia after exposure to tea, coffee, and cigarette smoke. MATERIALS AND METHODS: Zirconia specimens (N = 180; 12 × 12 × 2 mm)...

A Comparative Study of Penalized and Classical Variable Selection Methods

In linear regression models, multicollinearity affects regression parameter estimates and can lead to misleading results in selecting the true model. This study, therefore, undertakes a comparison of the performance of various variable selection methods under multicollinearity. T...

Challenges in the application of Semmes-Weinstein monofilament testing: practitioner-related variables

Objectives: The Semmes-Weinstein monofilament (SWM) test is commonly used to evaluate tactile sensation in individuals with neurological or orthopedic conditions. This study aimed to examine practitioner-related factors affecting SWM testing, particularly focusing on adherence to...

Lonely at Work: The Moderating Role of Leader–Member Exchange in the Association Between Workplace Loneliness and Perceived Task and Contextual Performance

The current study examined the moderating role of leader–member exchange (LMX) in the associations between workplace loneliness and employees’ perceived task and perceived contextual performance. Specifically, the study explored whether the negative associations between workplace...

The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility

Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline. Progressive ext...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF

Obesity affects nearly one in three women of reproductive age worldwide and consistently reduces success rates in in vitro fertilization, yet the molecular basis for this reduction remains fragmented across separate lines of evidence. Circadian clock genes, particularly BMAL1, or...

Arm position matters: Changes in vastus medialis activation during the single-leg squat in recreational athletes

The single-leg squat (SLS) is commonly used to assess lower-extremity neuromuscular performance. However, the effect of arm position on vastus medialis activation during the SLS remains unclear. This study aimed to investigate the effect of different arm positions on vastus media...

Global Research Trends in Pediatric Lower Urinary Tract Dysfunction: A Bibliometric Analysis (1945–2026)

Background/Objectives: Pediatric lower urinary tract symptoms and bladder–bowel dysfunction are common and clinically related problems recognized within the ICCS framework, but no bibliometric study has previously mapped this broad field comprehensively. This study aimed to map t...