Gülhane Askerî Tıp Akademisi

Glutathione and N-acetylcysteine in athletes: redox regulation and performance

Exercise-derived reactive oxygen species contribute to both cellular stress and training adaptation, creating uncertainty regarding the potential value of thiol-based antioxidant strategies in physically active populations. This structured narrative review critically evaluated hu...

Guideline-grounded retrieval versus unconfigured generation in obstructive sleep apnea: a pilot comparison of notebookLM and ChatGPT for AASM v3.0 PSG scoring-rule questions

Large language models (LLMs) are increasingly used in sleep medicine, but their reliability for polysomnography (PSG) scoring-rule tasks that require up-to-date guideline knowledge remains uncertain. This pilot study compared response quality when identical AASM v3.0 PSG scoring-...

Lipoedema in an adolescent male following valproate discontinuation: a case report

Serkan KEMER et al. "Lipoedema in an adolescent male following valproate discontinuation"p.

Acute exercise-related changes in hematological parameters and lymphocyte subsets before and after short‑term rapid weight loss in national‑level wrestlers: a pilot study

Abstract Background Rapid weight loss (RWL) is commonly used by wrestlers to qualify for lower weight categories, but the combined effects of RWL and intense exercise on circulating immune cell profiles, particularly lymphocyte subsets, remain incompletely characterized. This stu...

Machine Learning and MILP for Capacity Optimization and Educational Workload in Academic Endodontics

ABSTRACT Objectives Appointment scheduling in endodontic clinics is challenging due to heterogeneous treatment durations and varying practitioner competencies. Conventional scheduling methods frequently overlook these complexities, leading to underutilized unit capacity, extended...

Early changes in left ventricular mass index after empagliflozin initiation in type 2 diabetes: a retrospective cohort study

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) promote reverse cardiac remodeling; however, evidence regarding very early changes in left ventricular mass index (LVMI) in patients with type 2 diabetes without established cardiovascular disease remains limited. We evaluated 3-...

Clearance of amino acids, trace elements, and carnitine during CRRT: the carnitine dichotomy

Continuous renal replacement therapy (CRRT) provides vital organ support in acute kidney injury but is associated with the inadvertent extracorporeal clearance of essential low-molecular-weight nutrients. While the loss of amino acids and trace elements is clinically recognized,...

Emerging cfDNA technologies in glioblastoma through fragmentomics and sonobiopsy

Glioblastoma (GBM) is difficult to monitor using liquid biopsy because the tumor-derived fraction of circulating cell-free DNA (cfDNA), i.e., circulating tumor DNA (ctDNA), is often very low in plasma and because spatial and temporal heterogeneity complicate single-variant tracki...

Engineering Red Blood Cell Membrane-Coated PLGA Nanoparticles for Kahweol Delivery: Formulation Development and Pharmacokinetic Assessment

Kahweol is an active diterpene with anti-inflammatory, antioxidant, and anticancer properties; however, its use may be limited by unfavorable pharmacokinetic characteristics. This study aimed to develop kahweol-loaded poly(lactic-co-glycolic acid) (PLGA) and red blood cell membra...

Therapeutic Effects of Ganoderma lucidum Against Aβ-Induced Neurotoxicity in SH-SY5Y Cells: In Vitro Evidence and Computational Validation of Human Protein Targets

The triterpenoid and polysaccharide constituents of Ganoderma lucidum (GL) are believed to influence key pathogenic pathways in Alzheimer’s disease (AD). This study first examined the molecular rationale for GL’s neuroprotective properties by subjecting its principal triterpenoid...

The “Lock‐and‐Key” Advantage: Molecularly Imprinted Polymers in Modern Electrophoresis in Drug Assay

Molecularly imprinted polymers (MIPs) have gained increasing attention as synthetic recognition materials that mimic biological binding sites while offering greater stability and lower cost. In recent years, their combination with electrophoretic techniques has opened new possibi...

Meteorological factors and daily afebrile seizure counts in children: a time-series analysis

Abstract Background The relationship between meteorological factors and seizure occurrence remains controversial, particularly in pediatric populations where data are limited and may be confounded by febrile seizures. This study aimed to investigate the association between daily...

Development and effectiveness of a user-centered mobile application for informal caregivers of people living with dementia: randomized controlled trial

Abstract Background Dementia places substantial physical, psychological, and social demands on informal caregivers, and caregiving needs may change across the dementia trajectory as cognitive, behavioral, and functional changes alter day-to-day care demands. Digital interventions...

Large Language Models Versus Multidisciplinary Tumor Board Decisions in Thyroid Cancer

ABSTRACT Objectives Large language models (LLMs) are increasingly proposed as clinical decision‐support tools; however, their agreement with real‐world multidisciplinary tumor board (MDT) decisions remains insufficiently investigated in thyroid oncology. To evaluate the concordan...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Nurse Practitioner Roles and Contributions in a Mobile Health Clinic for People Experiencing Homelessness

ABSTRACT Aim To present a descriptive, practice‐based account of a nurse practitioner‐led mobile health clinic serving individuals experiencing homelessness, guided by the PRIME‐NP framework. Background Homelessness is associated with health inequities and limited access to care....

Hepatitis B in Isolated Anti-HBc Carriers: Predictors of Detectable HBV DNA and Implications for Risk-Stratified Screening

Background/Objectives: Isolated anti-HBc (IAHBc)—anti-HBc reactivity without HBsAg or anti-HBs—may indicate occult HBV infection (OBI) and confers reactivation risk under immunosuppression, yet most evidence derives from single specialties. We assessed the frequency, predictors,...

Effect of different surface treatments on the shear bond strength of one-step and two-step universal adhesives to enamel and dentin

This study evaluated the effect of surface treatments on the shear bond strength of one- and two-step universal adhesives applied to enamel and dentin. Eighty extracted human molars were allocated to five experimental conditions: etch-and-rinse phosphoric acid application, Er:YAG...

Comparative assessment of occlusal and proximal caries detection using an intraoral scanner and panoramic radiography

Recently, fluorescence-based caries detection has been integrated into intraoral scanners as a radiation-free adjunctive tool for caries assessment. However, evidence regarding the agreement of these systems with conventional diagnostic methods remains limited. Therefore, the aim...

Oral Cancer Awareness, Screening Behavior, and Risk-Factor Recognition Among Patients Attending a University Dental Hospital

Background: Oral cancer remains a major global health concern, with increasing incidence and mortality, especially in developing countries. Public awareness is crucial for early detection and improved outcomes. Objective: To assess oral cancer awareness, recognition of risk facto...