Guiyang Medical University

Differences in perceived influences and educational support needs of generative AI among medical and nursing students across educational levels: a descriptive qualitative study

Generative artificial intelligence (GAI) has been extensively integrated into nursing and medical education, significantly transforming the academic practices of students. Nonetheless, the varying impacts of GAI on core competency of student across educational stages remain ambig...

Serial Cross‐Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric MRI and Histopathology

ABSTRACT Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non‐invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping...

Superiority of Tetrapeptide Tyr–Gly–Leu–Phe over Amino Acid Mixture: Mechanisms Underlying Enhanced Systemic Amino Acid Delivery, Anti-Fatigue Efficacy, and Muscle Damage Repair

Abstract This study compared the anti-fatigue tetrapeptide YGLF with an equimolar amino acid (AA) mixture across three stages: postingestion absorption, postexercise fatigue, and muscle damage repair. Despite rapid in vitro degradation (<1% intact), YGLF elevated plasma AAs more...

Biosynthetic DNA origami nanostructures: harnessing E. coli-phage systems as nanofactories

DNA origami nanostructures (DONs) serve as versatile nanocarriers with promising application potential, but high production cost and low yield limit their development. The biosynthetic approach based on the Escherichia coli ( E. coli )-phage system offers an effective route for t...

Synthesis and biological characterization of formononetin derivatives against phytopathogenic oomycete and bacteria: preliminary mechanisms, theoretical predictions, and biosafety evaluation

Abstract Background The increasing prevalence of phytopathogenic oomycetes and bacteria, particularly Phytophthora capsici ( Pc ) and Xanthomonas oryzae pv. oryzae ( Xoo ), poses severe threats to global agricultural production. Developing novel antimicrobial agents with dual ant...

Does EQ-5D measure the most relevant aspects of health across cultures? Findings from a multi-country qualitative and card-sorting study

The EQ-5D is a widely used measure of health-related quality of life (HRQoL) in health services and economic evaluations globally. However, its cross-cultural content validity remains underexplored. This study assesses the relevance and adequacy of EQ-5D across diverse cultural c...

A telomere-to-telomere reference genome for Rosa roxburghii reveals lineage-specific diversification of triterpenoid biosynthesis

Abstract Rosa roxburghii ( RRT ) is a nutritionally and medicinally important Rosaceae species that accumulates diverse bioactive compounds, making it an excellent system for investigating the genetic basis and evolutionary diversification of specialized metabolism. Here, we repo...

Independent prognostic value of the blood urea nitrogen-to-albumin ratio beyond the creatinine-to-albumin ratio among eICU patients with recorded sepsis and acute respiratory failure: a retrospective cohort study

Patients recorded as having both sepsis and acute respiratory failure (ARF) constitute a high-risk critically ill population, although historical database-based sepsis classifications may not correspond directly to contemporary Sepsis-3 criteria. The blood urea nitrogen-to-albumi...

Genomic characteristics and evolutionary analysis of Bordetella pertussis in Guizhou Province, China

Abstract Background Pertussis is an acute infectious respiratory disease caused by Bordetella pertussis (Bp). Despite high vaccination coverage, the genome of B. pertussis is prone to variations. These variations can lead to vaccine immune escape, recurrence of outbreaks, and inc...

Tuning σ-Hole Chalcogen···Nitrogen Bonding Between C2F4Ch2 and Nitrogen Bases: Dual Modulation by Chalcogen Atomic Size and Nitrogen Hybridization (Ch = S, Se, Te, Po)

Abstract Chalcogen bonds (ChBs), a prominent subclass of σ-hole interactions in which Group 16 elements serve as electrophilic sites, have attracted considerable attention in recent years because of their pivotal roles in diverse chemical and biological systems. However, the comb...

Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging

Preeclampsia (PE) affects 3%-5% of pregnancies worldwide and is a leading cause of maternal/perinatal mortality, yet its etiology remains unknown. We established a PE rat model using L-NAME to investigate postpartum cognitive dysfunction and its mechanisms, evaluated brain micros...

SARS-CoV-2 NSP14 suppresses RIG-I-mediated interferon production by dampening the interaction between DHX15 and RIG-I

Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) imposes serious public health and economic burdens worldwide. SARS-CoV-2 has evolved a formidable arsenal of evasion strategies to outmaneuver innate immune responses. However, the role of nonstructural p...

A Selective ERα Photodegrader for Precise and Efficient Breast Cancer Treatment

Abstract Breast cancer is the most prevalent malignancy in women, with over 70% of cases being estrogen receptor α (ERα)-positive. Photodynamic therapy (PDT) is spatially precise yet limited by tumor-selective photosensitizers. Herein, we report the first co-crystal structure of...

Diagnostic value of LRG-1 in combination with inflammatory factors for the severity and poor prognosis of acute cholecystitis

Accurate stratification of acute cholecystitis (AC) severity and prognosis remains challenging. Leucine-richα-2-glycoprotein-1 (LRG-1) is an inflammatory biomarker, but its role in assessing AC severity has not been studied. This study aimed to investigate the diagnostic and prog...

Cost-Utility Analysis of Comprehensive Integrated Management for Psoriasis and Periodontitis: A Markov Cohort Study

Objectives Psoriasis and periodontitis co-occur in Chinese adults beyond chance expectation, sharing proinflammatory pathways. We modelled the long-term economic value of integrating periodontal care into psoriasis management in China. Methods A nine-state Markov cohort model (1-...

Bedside rapid lactate-creatinine-to-platelet ratio score and short-term mortality prognosis in patients with aspiration pneumonia complicated by sepsis: a multicenter cohort study

This study aimed to investigate the association between the rapid bedside Lactate-Creatinine-to-Platelet Ratio (LCPR) and short- to medium-term mortality prognosis in patients with aspiration pneumonia complicated by sepsis. This retrospective database-based observational study i...

ZIF-8-Based Smart-Responsive Nanocomposites for Cutaneous Wound Healing: A Review

Abstract Cutaneous wound healing is a complex process that requires precise management. In recent years, intelligent, responsive biomaterials have played a crucial role in guiding wound healing through these stages in a physiologically ordered manner. Zeolitic imidazolate framewo...

Modulation of CD73 by Betulinic acid antagonizes nucleotide metabolic dysregulation in silica nanoparticle-induced pulmonary fibrosis

Silica nanoparticles (SiNPs) exposure presents a growing public-health concern. The mechanisms driving SiNPs-induced pulmonary fibrosis and effective interventions remain unclear. This study investigated the contribution of CD73 to SiNPs-induced pulmonary fibrosis and evaluated t...

Breaking upstream–downstream linkage obstacles for efficient, economical, and green production of high-molecular-weight poly(β-L-malic acid)

Abstract Background Poly(β-L-malic acid) (PMA) is a biodegradable, biocompatible, and chemically modifiable polymer with broad applications. However, the production of high-molecular-weight, high-purity PMA (hhPMA) has long been constrained by “upstream–downstream linkage obstacl...

Beyond motor symptoms: associations between sleep disorders and multidomain functional decline in Parkinson’s disease

Sleep disorders are associated with functional outcomes in Parkinson’s disease (PD), yet their multidomain clinical correlates remain incompletely characterized. We analyzed 9195 participants from the National Alzheimer’s Coordinating Center database using inverse probability wei...