Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Ventilator-induced lung injury (VILI), an iatrogenic complication of mechanical ventilation, remains poorly understood due to the absence of physiologically relevant in vitro models, impeding targeted therapy development. Here, we engineer a bioinspired acinus-on-a-chip model rec...