Guangxi University

ERFMTDA: Predicting tsRNA–disease associations using an enhanced rotative factorization machine

Abstract Motivation tRNA-derived small RNAs (tsRNAs) have emerged as a novel class of regulatory molecules implicated in the pathogenesis of many human diseases, making them as promising biomarkers and therapeutic targets. However, existing computational methods for tsRNA–disease...

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

ABSTRACT Atherosclerotic cardiovascular disease (AS) remains a leading global health concern. In this study, we investigated a macrophage‐derived exosome‐based delivery system for puerarin (Pue). The isolated vesicles were characterized by transmission electron microscopy, partic...

Comparative analysis of TP53 gene in Tupaia belangeri subspecies ( Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis ) and identification of mutations in spontaneous tumor cases

The tree shrew (Tupaia belangeri) is an emerging animal model for human diseases, yet the status of the critical tumor suppressor TP53 in its subspecies and spontaneous tumors is unknown. We sequenced the entire TP53 coding region from two subspecies, T. b. yaoshanensis and T. b....

Lamellar high-entropy TiVCrMoC3 MXene enabling excellent hydrogen storage kinetics and cyclic stability of MgH2 via multi-phase interfaces and multiple transition metals effects

MgH2 is a promising hydrogen storage medium, but its industrial use is hindered by high dehydrogenation temperatures and sluggish kinetics. Herein, a lamellar high-entropy TiVCrMoC3 MXene was synthesized via HF-mediated etching of a TiVCrMoAlC3 MAX precursor and integrated into M...

Chemical Diversity and Microbial Complexity of Liupao Tea Aroma: A Comprehensive Review

Liupao tea (LPT), one of China’s representative fermented dark teas, develops its unique “red, heavy, aged, and mellow” flavor characteristics. This review provides a comprehensive update on LPT aroma, integrating analyses of volatile organic compounds (VOCs), associated microorg...

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...

Regulatingthe Arrangement of Planar Ligands in LanthanideMetal–Organic Framework Photosensitizers to Induce a PhotocatalyticReactive Oxygen Species Storm for Sewage Purification and PhotodynamicSterilization

Abstract Constructing lanthanide metal–organic frameworks (Ln-MOFs) that are both water-stable and capable of efficiently generating reactive oxygen species (ROS) remains a significant challenge in the field of photocatalytic water remediation. In this study, two structurally rob...

The First X-Ray Polarimetry of the Typical Accretion Disk Corona Source 4U 1822-37

Abstract We report the first Imaging X-ray Polarimetry Explorer (IXPE) observations of the typical accretion disk corona (ADC) source 4U 1822-37, covering 44 orbital cycles, together with simultaneous Swift-XRT data. The polarization degree (PD) of this source is found to be high...

Modification GeneKnockout Diversifies Piericidinsfrom the Marine-Derived Streptomyces psammoticus SCSIO NS126

Abstract Piericidins are α-pyridone agricultural antibiotics produced by actinomycetes. To improve their yield and structural diversity from marine-derived Streptomyces psammoticus SCSIO NS126, this study employed homologous recombination to achieve large-fragment knockout of mod...

Elastic modulus recovery in concrete incorporating biomimetically mineralized recycled aggregates

Abstract The structural application of recycled aggregate concrete (RAC) is severely hindered by its low elastic modulus, primarily caused by porous adhered mortar and defective interfacial transition zone (ITZ). This study proposes a novel biomimetic mineralization strategy to c...

Rhizoxin and 2,4-diacetylphloroglucinol contribute to biocontrol of Pseudomonas protegens Pf-5 against pea Ascochyta blight pathogen Didymella pinodes

ABSTRACT Biological control using beneficial bacteria is a promising strategy for managing pea Ascochyta blight (AB), yet the underlying mechanisms remain poorly understood. In this study, we identified 10 bacterial strains from 4 genera, including Bacillus , Paenibacillus , Peri...

MiPEP133 enhances anti-tumor immunity in nasopharyngeal carcinoma by activating CD8 + T cells

Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. RNA-Seq was used to assess miPEP133’s effect on NPC cells and T-cell-...

Comparative Genomic and Transcriptomic Analyses of 60Co-Mutagenized Scheffersomyces stipitis Strains: Identification of Candidate Genes Associated with High-Ethanol-Producing Xylose-to-Ethanol Fermentation

Sugarcane bagasse is an important renewable lignocellulosic resource, yet its bioconversion efficiency remains low, primarily because wild-type Saccharomyces cerevisiae cannot utilize xylose, which limits the industrial production of cellulosic ethanol. In this study, a high-etha...

Effects of Chemically Modified Three-Dimensional Porous Graphene for the Optimal Rheology and Mechanics of Cement Composite

Abstract Although graphene significantly enhances the performance of cement-based materials, its tendency to agglomerate in strongly alkaline cement paste environments and its high cost limit practical applications. To overcome these challenges, this study employed polycarboxylat...

Highly Viscoelastic Rubber Extrusion: Evolution and Future Perspectives—A Review

Rubber extrusion has evolved through overlapping advances in equip design, rheological characterization, numerical modeling, sensing, and control. This structured critical narrative review synthesizes 180 sources published from 1972 to 2026, assembled through iterative keyword se...

Latent class analysis of sexual behavior and HIV testing profiles among sexually experienced college students in China: a cross-sectional online survey

Rising human immunodeficiency virus (HIV) infections among young people underscore the need to strengthen campus-based prevention. We used latent class analysis (LCA) to summarize sexual behavior and HIV-testing profiles among sexually experienced college students, examine associ...

Calcium Chloride Activation of Acid-Washed Sewage Sludge Ash: Hydration Mechanism and Performance as a Supplementary Cementitious Material

Due to the fact that municipal sludge incineration generates a large amount of toxic sewage sludge ash (SSA), cement solidification is becoming an efficient harmless treatment method. However, the large amount of phosphorus in sludge ash can delay the setting time of cement paste...

Triaxial Compressive Properties of Graphene Oxide-Modified Concrete

Thirty specimens of graphene oxide-modified concrete (GOMC) were prepared with curing age, graphene oxide (GO) dosage, and lateral confining pressure as the test variables. Complete stress–strain curves under triaxial compression were obtained, elucidating the failure mechanism a...

Pt Nanoparticles on Graphene Doped by Boron Carbide With Strong Electronic Metal–Support Interaction for Efficient Ultra‐Low Pt Loading Proton Exchange Membrane Fuel Cells

ABSTRACT Developing a durable cathode catalyst layer (CCL) with ultra‐low Pt loading <50 µg Pt cm −2 for oxygen reduction reaction (ORR) is essential to substantially advancing the wide adoption of proton exchange membrane fuel cells (PEMFCs). Herein, a robust CCL was develope...

Integrated Transcriptomic Profiling Reveals Candidate Genes for Huperzine A Biosynthesis in Huperzia serrata

Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application. This study integrates full-length and...