Guangdong Pharmaceutical University

PPARγ/P21 Signaling Mediates Butyrate-Driven Protection against Aging-Related Endothelial Dysfunction: A Novel Effect of Soybean Polysaccharide via the Gut-Vascular Axis

Abstract Aging-induced endothelial dysfunction is a core driver of age-related cardiovascular diseases (CVDs). In 20-month-old naturally aged mice, 12-week soybean polysaccharide (SP) supplementation restored endothelium-dependent relaxation, reduced aortic reactive oxygen specie...

Evaluation and validation of a reproducible mNGS workflow for gut Microbiome analysis

Technical variability in pre-analytical and analytical steps significantly hinders the reproducibility of gut metagenomic next-generation sequencing (mNGS). To address this, we developed and evaluated a practical workflow for mNGS. By evaluating three commercial preservation buff...

A geometry-aware Bi-level reduced-order model for state-field reconstruction and exergy-flux evaluation in closed wet cooling towers

Tube-bundle geometry governs the coupled airflow, evaporation, heat transfer, and pressure loss in closed wet cooling towers, making repeated computational fluid dynamics (CFD) simulations costly for design under uncertain ambient conditions. This study develops a geometry-aware...

QCFSNet: A Quaternion-Guided Inter-Channel and Frequency-Spatial Feature Interaction Strategy for Endoscopic Image Segmentation

In the field of medical consumer electronics, particularly in cervical cancer diagnostics, endoscopic imaging is often affected by uneven illumination and the high similarity in textures and features between lesion regions and surrounding tissues, which severely hinders accurate...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Advances in Photochemical Alkene Difunctionalization via Electron Donor–Acceptor (EDA) Complexes

Alkenes are ubiquitous and versatile feedstocks in organic synthesis. Alkene difunctionalization, which enables the simultaneous installation of two functional groups across the carbon–carbon double bond, represents a highly efficient strategy for constructing complex molecular a...

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

Abstract Both NSD2 and GSPT1 represent compelling targets for anticancer drug discovery. Herein, we carried out single-atom modification of LLC0424, an NSD2 degrader with GSPT1 neosubstrate engagement, to yield two structurally analogous molecules with divergent modes of action:...

Engineered exosome MDC@Ex-γ3-CeO₂@PDA for multi-target therapy of sepsis-induced acute lung injury

Sepsis-induced acute lung injury (ALI), with a complex pathogenesis, currently lacks clinically effective multi-target therapeutic strategies. Musca domestica cecropin (MDC), a promising antimicrobial, anti-inflammatory, and endothelial-repairing peptide, is limited by its high m...

A Modular (1,3-Oxathiolan-2-yl)ethoxy Trigger Unlocks Activatable Probes for In Vivo Imaging of Hypobromous Acid

Abstract Hypobromous acid (HOBr) is a critical reactive oxygen species in inflammatory pathology; however, tracking its dynamics in vivo remains a formidable challenge. Herein, we report a convenient, sensitive and selective (1,3-oxathiolan-2-yl)ethoxy (OTE) recognition moiety fo...

Post-Competitive Interface Reprogramming for Amplified Multiplex Bacterial Fingerprinting in Biofluids

Abstract Low-burden bacterial infections demand rapid and reliable pathogen fingerprinting, yet cross-reactive sensor arrays remain limited by weak and overlapping optical signatures. Here we introduce postcompetitive interface reprogramming (PCIR), a sensor-array strategy that e...

Modeling the Impact of Active Site Mutations on the Quenching Fate and Cyclization Depth of a Rare Oxidosqualene Cyclase

Abstract Oxidosqualene cyclases (OSCs) convert linear 2,3-oxidosqualene into diverse polycyclic triterpenoids. The precise control over highly reactive carbocation intermediates, particularly the ultimate quenching mechanism (deprotonation vs hydroxylation), remains a fundamental...

Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy

Abstract Epidermal growth factor receptor (EGFR) kinase inhibitors have revolutionized non-small cell lung cancer (NSCLC) treatment; however, the inevitable acquired resistance necessitates alternative strategies beyond conventional inhibition. Herein, we report the discovery and...

A Microneedle Platform Co-loaded with Eugenol, Chlorogenic Acid, and Allopurinol for In Vivo Modulation of Pathological Crystal Formation in Experimental Gouty Arthritis

Abstract Gouty arthritis arises from pathological deposition of monosodium urate (MSU) crystals, whose interactions with surrounding tissues initiate and amplify inflammation. Here, we developed a nanoengineered microneedle (MN) platform for localized modulation of pathological c...

Preclinical toxicity and immunogenicity of a quadrivalent recombinant influenza hemagglutinin vaccine (SCVC101) in rhesus monkeys

SCVC101 is a novel recombinant hemagglutinin (rHA) protein-based quadrivalent seasonal influenza vaccine containing HA gene sequences of A/Wisconsin/588/2019 (H1N1) pdm09-like virus, A/Cambodia/e0826360/2020 (H3N2)-like virus, B/Washington/02/2019 (B/Victoria lineage)-like virus,...

Go-Game-Driven Introduction to Monte Carlo Simulation of Langmuir Adsorption

Abstract The ancient Chinese strategy game Go is an ideal analogical anchor for teaching the Langmuir monolayer adsorption model. Well-crafted gameplay that integrates Go sets with dice rolls can simulate stochastic molecular collisions and visualize complex computational logic....

Physical activity and sleep associations with episodic memory across four ageing cohorts: a coordinated within-person analysis

Longitudinal associations of physical activity and sleep with cognitive ageing can mix between-person differences with within-person change. Consistency in direction and magnitude across cohorts remains unclear, particularly when sleep measures capture different symptoms. We comp...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

The Allergen Detective: An Undergraduate GC-FID/MS Laboratory Activity for Investigation of Volatile Ingredients in Essential Oil

Abstract This laboratory experiment introduces a natural volatile product analysis experiment for undergraduate students majoring in chemistry and pharmacy, helping students to gain a deeper understanding of chromatographic methods in natural-product analysis. It involves the use...

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims t...