Guangdong Medical College

Fifty-year trends and future projections of nasopharyngeal carcinoma incidence in Sihui City, southern China: an age-period-cohort analysis (1971–2020)

The long-term trend of nasopharyngeal carcinoma (NPC) in traditional high-prevalence areas of Southern China remains poorly characterized. This study aimed to delineate the 50-year incidence trends (1971–2020) and project future rates up to 2040 in Sihui, a well-known endemic reg...

Triglyceride-high-density cholesterol-glucose-body index and risk of impaired fasting glucose in normolipidemic adults: a secondary analysis of a multicenter cohort

The triglyceride-high-density cholesterol-glucose-body index (TyHGB) is a composite index incorporating routinely measured lipid, glucose, and anthropometric parameters. However, its longitudinal association with the risk of impaired fasting glucose (IFG), a critical prediabetic...

Associations between non-insulin-based insulin resistance surrogates and pulmonary hypertension due to left heart failure: a multicenter cohort study

Abstract Background Insulin resistance (IR) has been reported to have a close relationship with the development and adverse outcomes of various cardiovascular disorders, while its association with pulmonary hypertension due to left heart failure (PH-HF) remains to be elucidated....

Comparison of Postoperative Complications and Perioperative Outcomes Between Endoscopic-Assisted and Open Prosthetic Breast Reconstruction: A Retrospective Study

AIM: To compare the incidence of complications within 90 days postoperatively and perioperative outcomes between endoscopic-assisted and open prosthetic breast reconstruction.METHODS: Data from female patients who underwent total mastectomy and prosthetic breast reconstruction fr...

Shear Wave Elastography of the Tibial Nerve and Lower Limb Nerve‐Muscle‐Tendon Complex in Diabetic Peripheral Neuropathy

Objectives To investigate the associations among diabetic peripheral neuropathy (DPN), diabetic tendinopathy, and diabetic myopathy and their respective influencing factors using shear wave elastography (SWE). Methods This study enrolled 65 diabetic patients (22 with DPN [PN‐DM g...

Monitoring neutrophil extracellular traps (NETs) related citrullinated histone H3: a novel biomarker of recurrence and metastasis in nasopharyngeal carcinoma

Abstract Objectives Blood-based biomarkers play a crucial role in tumor monitoring. However, for nasopharyngeal carcinoma with recurrence or metastasis (R/M-NPC), there is a notable scarcity of sensitive markers. Citrullinated histone H3 (H3Cit), a key marker of neutrophil extrac...

Reframing decentralized diagnostics with a programmable multi-dimensional microfluidic system

Decentralized diagnostics are vital for infectious disease control, yet current point-of-care tools remain largely one-dimensional, failing to capture the multidimensional profiles required for precision management. Here, we show SID-WAVES (Smartphone-Integrated Diagnostics with...

Pan-African genomics of Pseudomonas aeruginosa highlights regional population structure and AMR stratification

Abstract Background Pseudomonas aeruginosa is a leading cause of life-threatening nosocomial infections and a World Health Organization "Priority 1" critical pathogen. Despite the escalation of global antimicrobial resistance (AMR), the genomic landscape of P. aeruginosa across A...

Phenothiazine-Driven Autophagic Response in Macrophages as an Anti-cutaneous Tuberculosis Approach

Abstract Cutaneous tuberculosis (CTB), caused by Mycobacterium tuberculosis (Mtb) infection of the skin, remains a global health burden, underscoring the urgent need for more effective drugs and therapeutic strategies. In this study, we discovered a phenothiazine-based derivative...

Immunogenetic determinants of influenza B virus susceptibility and vaccine response: current evidence, gaps, and future directions

Influenza B virus (IBV) remains an important but comparatively underexamined contributor to seasonal influenza burden, particularly in children, adolescents, and older adults. Although IBV lacks the broad animal reservoir and pandemic potential of influenza A virus, its epidemiol...

Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function

Background FXI (Factor XI) inhibitors have emerged as a promising antithrombotic strategy. However, a recent study linked decreased FXI levels with increased risk of heart failure (HF) and atrial fibrillation (AF), particularly in older adults. This study aims to investigate the...

Nano-NucleOTAC-mediated Z-DNA transformation disrupts mycobacterium tuberculosis biofilms and activates antibacterial immunity

The biofilms of Mycobacterium Tuberculosis (Mtb) use extracellular DNA (eDNA) as a protective structural scaffold that shields resident bacteria from host immunity and antibiotics, promoting persistent infection. An FDA-approved DNase can partially hydrolyze eDNA but has limited...

The imperative of newborn screening programs in developing countries: beyond the illusion of health at birth

Newborn screening (NBS) represents one of the most significant achievements in preventive public health, enabling early detection of congenital disorders before symptom onset. While developed nations have established comprehensive NBS programs covering 30–50 conditions, many low-...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

An eight-variable risk model for short- and long-term mortality in hospitalized heart failure

Abstract Heart failure (HF) is a leading cause of hospitalization and death worldwide, yet most prognostic models target long-term outcomes and are not optimized for acute-phase risk stratification. This study developed and externally validated an 8-variable Cox model for predict...

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA...

Pleura organoid transplantation facilitates visceral pleural repair through CD133+ progenitor cell-mediated regeneration

Abstract Persistent pulmonary air leakage following thoracic surgery remains a major clinical challenge. Here we establish murine and human pleura organoids as a novel regenerative therapy. Morphological and functional analyses confirm that these organoids retain mesothelial mark...

HLA class I expression and tumor immune infiltration together shape colon cancer immune contexture

Background The relative contribution of HLA class I molecules—including classical HLA class Ia (HLA-A, -B, -C) and non-classical HLA class Ib (HLA-E, -F, -G)—to shaping the tumor immune microenvironment in colon cancer remains insufficiently defined. We investigated how their exp...

Macrocyclization of native peptides through (thio)urea crosslinking of two amines

Cyclopeptides have emerged as promising candidates for drug development. However, owing to the scarcity of efficient cyclization strategies for natural peptides, the development of diverse cyclopeptides remains a formidable challenge. In this study, a variety of macrocyclic pepti...

Neonatal hypoxia promotes pulmonary hypertension by upregulating ALKBH5 expression

Postnatal hypoxia in high-altitude regions drives pulmonary developmental impairment in neonates, which may subsequently progress to pulmonary hypertension and right ventricular failure. N6-methyladenosine (m6A) RNA modification regulates mRNA fate and cellular responses to stres...